Results 11 to 20 of about 14,898,439 (169)
Journal of Diabetes, Volume 15, Issue 5, Page 368-381, May 2023., 2023 Highlights This study is the first registered meta‐analysis with three different insights to explore the relationship between the glycated hemoglobin (HbA1c) variability and the risk of cardiovascular disease (CVD). Our study suggests that the higher glucose fluctuation is significantly associated with the higher CVD risk in diabetes patients based on ...
Feng Li +6 more
wiley +1 more source
血小板/淋巴细胞比值在慢性阻塞性肺病急性加重早期诊断中的应用价值
Zhongguo shiyan zhenduanxue, 2022 目的 评估血小板/淋巴细胞比值在慢性阻塞性肺病急性加重早期诊断中的应用价值。方法 回顾性研究南京医科大学附属苏州医院呼吸与危重症医学科2019年3月至2021年6月住院治疗151例慢性阻塞性肺病患者的一般临床资料。分为AECOPD组（急性加重组）和SCOPD组（稳定期组），比较两组患者的一般临床资料、PLR、降钙素原、C反应蛋白等的差异。通过受试者操作特征（ROC）曲线下的面积（AUC）评估PLR及相关危险因素在慢性阻塞性肺病急性加重早期诊断中的临床价值。结果 ACCOPD组患者年龄、吸烟比例 ...
徐靖宇 +4 more
doaj
Rare Metals, Volume 45, Issue 6, June 2026.ABSTRACT Bone restoration is often hindered by the spatiotemporal dysregulation of immune and regenerative signals. Conventional bio‐inert implants, providing only passive support, fail to modulate this microenvironment, leading to infections and poor healing.
Zhizhong Sun +8 more
wiley +1 more source
, 2007 自然衰老和慢性应激都能导致免疫细胞对环境刺激的抵抗力降低.衰老和慢性应激影响免疫细胞功能的分子机制目前还不清楚.热休克蛋白(HSP)是一类在所有原核细胞和真核细胞中均有表达的高度保守的蛋白质.研究表明,HSP反应是细胞维持正常功能,对抗应激性损伤的基本保护性机制之一.在HSP家族中,热休克蛋白70(HSP70)对应激条件最敏感,且被认为是功能最重要的一类热休克蛋白[1].本文综述衰老和慢性应激对免疫细胞HSP70表达的抑制作用及其调节机制.国家自然科学基金中国科技核心期刊(ISTIC)中国科学引文数据库(
王玮文, 邵枫, 刘美, 林文娟
core +1 more source
Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova +6 more
wiley +1 more source
Integrative Conservation, Volume 4, Issue 4, Page 652-664, December 2025.We profiled nutritional and physiological markers in captive sifakas, endangered primates from Madagascar, managed in expansive, non‐native forest enclosures. Variation in many markers reflects freely foraged diets and the energy required to maintain homeostasis under more naturalistic conditions.
Lydia K. Greene +5 more
wiley +1 more source
Veterinary Dermatology, Volume 36, Issue 4, Page 453-461, August 2025.Background – Canine atopic dermatitis (cAD) is a chronic, inflammatory, multifactorial and pruritic disease. The presence of skin barrier impairment (e.g. filaggrin alterations), along with abnormal immune responses, can negatively impact cutaneous barrier function.
Wendie Roldan Villalobos +5 more
wiley +1 more source
Veterinary Dermatology, Volume 35, Issue 6, Page 736-744, December 2024.Background – Topical therapy is preferred for otitis externa (OE) in dogs, and otic products commonly contain glucocorticoids that can be systemically absorbed and possibly interfere with diagnostic tests such as intradermal testing (IDT). Hypothesis/Objectives – To determine the effect of a long‐lasting otic solution containing mometasone furoate (MF)
Jennifer L. Clegg +2 more
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2014 C反应蛋白属于急性时相反应蛋白,是炎症反应的标志性蛋白。在正常健康人体内的C反应蛋白水平较低,当机体组织发生感染或者组织损伤后,其水平在6-8h后开始升高,在24-48h内水平达到最高[1-4]。本文选择我院急性呼吸道感染患儿,观察C反应蛋白水平检测在此类患儿中的临床意义,现报告如下。1资料和方法1.1一般资料所选急性呼吸道感染患儿共62例 ...
何书香
doaj
Veterinary Dermatology, Volume 35, Issue 6, Page 595-604, December 2024.Background – Mycobacterium cell wall fraction (MCWF) is derived from nonpathogenic Mycobacterium phlei and is used as an immunomodulatory compound in clinical practice, yet its mode‐of‐action requires further research. Objective – To evaluate the host response to MCWF in canine peripheral blood mononuclear cells (PBMCs) by using enzyme‐linked ...
Robert Ward +9 more
wiley +1 more source