Results 91 to 100 of about 10,732,131 (260)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Efficacy of Phage Therapy in Multidrug-Resistant Diabetic Foot Infections: Critical Literature Review

Iatreia
Introduction: Diabetes is a chronic metabolic disease that presents complications such as diabetic foot syndrome, expressed by ulcerations susceptible to infection by multidrug-resistant bacteria, making more difficult its treatment with conventional ...
Barrios-Barbosa, Katalina, López-Medina, Ralph Marien, Rodríguez-Panduro, Mauricio Huberto   +2 more
doaj   +1 more source

Mejoramiento continuo en el proceso de aprovisionamiento de alimentos en el área de nutrición a pacientes a través de manufactura esbelta

Avances, 2019
El objetivo del artículo es desarrollar una propuesta de mejoramiento continuo en el área de nutrición de una empresa del sector alimenticio. La metodología propuesta considera las siguientes etapas: identificación de las operaciones básicas del proceso ...
Ángela Johana Zambrano Rincón, Leidy Lorena Salazar Figueroa   +1 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Brote de toxoplasmosis pulmonar en militares inmunocompetentes

Biomédica: revista del Instituto Nacional de Salud
La toxoplasmosis es una infección zoonótica frecuente con diversos mecanismos de transmisión y distribución amplia a nivel mundial. Su probabilidad de generar enfermedad está relacionada con la alteración del sistema inmunológico y la virulencia del ...
Raúl Reyes-Toledo, Laura Culma-Roa, María José López, Jairo Enrique Pérez, David Suárez-Silva   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Colonias penales agrícolas de los siglos XIX y XX como sustitución de la pena de prisión tradicional en Colombia

Revista Criminalidad, 2012
El artículo desarrolla el tema de la política criminal de los siglos XIX y XX y su influencia en el sistema penitenciario colombiano, concretamente en la isla prisión Gorgona y las colonias penales de Araracuara y de Oriente, dentro del panorama ...
Omar Huertas-Díaz, Lynda Layda López-Benavides, Carlos Mario Malaver-Sandoval   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Change Point Detection in Radar Reflectivity Measurements Contaminated by Speckle Noise

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
This article studies the use of airborne global navigation satellite system reflectometry techniques for remote sensing applications at regional scale.
Sarah El Hajj Chehade, Hamza Issa, Georges Stienne, Serge Reboul   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source