Results 241 to 250 of about 53,609 (266)

c-erbB-2 Oncogene Expression in Salivary Gland Tumours

ORL, 1994
Prompted by recent findings on the amplification of c-erbB-2 (HER-2, neu) oncogene in salivary gland tumours, the present study was conducted to analyse the expression of c-erbB-2 in both benign and malignant salivary gland tumours, with special emphasis on its prognostic significance and relevance to clinical data.
V, Kärjä, S, Syrjänen, V, Kataja, K, Syrjänen   +3 more
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c-erbB-2 amplification in mammary carcinoma

Journal of Cellular Biochemistry, 1993
The c-erbB-2 oncogene has been extensively studied in mammary carcinomas since Slamon and colleagues demonstrated the association between amplification and poor prognosis in 1987. Further work found that amplification was accompanied by overexpression of the protein; however, this relationship is not perfect.
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C‐erbB‐2 expression and prognostic significance in osteosarcoma

Pediatric Blood & Cancer, 2008
AbstractBackgroundC‐erbB‐2 is postulated as a prognostic biological marker for osteosarcoma (OST). We investigated c‐erbB‐2 expression status in osteosarcomas and its prognostic significance.ProcedureArchival pre‐treatment tumor biopsies of 79 cases were stained by immunohistochemical (IHC) methods with CB11 antibody for cell‐membrane specific c‐erbB‐2
Bilgehan, Yalçin, Gökhan, Gedikoğlu, Tezer, Kutluk, Ali, Varan, Canan, Akyüz, Münevver, Büyükpamukçu   +5 more
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c-erbB-2 as a target for immunotherapy

Expert Opinion on Investigational Drugs, 1998
The c-erbB-2 proto-oncogene encodes a 185 kDa transmembrane Type 1 tyrosine kinase receptor whose amplification and/or overexpression has been linked with poor prognosis in a variety of cancers. The oncoprotein has been suggested to play a key role in tumour cell invasion, motility and metastasis, and in responsiveness to therapeutic agents.
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Eradication of c- erbB-2-Positive Ovarian Cancer Cells Mediated by Intracellular Expression of Anti-c- erbB-2 Antibody

2003
Overexpression of erbB-2 is important in the pathogenesis of a variety of human neoplasms. Overexpression of the erbB-2 gene product has been associated with poor clinical prognosis with respect to malignancies originating in the ovary, breast, gastrointestinal tract, salivary gland, and lung (1-4) and has led to the development of several therapeutic ...
J, Deshane, R D, Alvarez, G P, Siegal
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Expression of c-erbB-2 in Human Pancreatic Adenocarcinomas

Pathobiology, 1991
The c-erbB-2 (neu) gene encodes a transmembrane phosphoglycoprotein (p185erbB-2) which resembles a growth factor receptor-like molecule closely related to the epidermal growth factor receptor. Overexpression of c-erbB-2 induces cell transformation in vitro.
T M, Williams, D B, Weiner, M I, Greene, H C, Maguire   +3 more
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c- erbB-2 Immunohistochemistry in Paraffin Tumors

2003
Immunohistochemistry is the study of the intracellular distribution of antigens based on the formation of an immune complex. The concept is based on the application of a specific antibody to the antigen to be detected and visualization of the antigen-antibody reaction with a staining procedure.
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C-erbB-2, EGF-Rezeptor, p53 und PCNA

Geburtshilfe und Frauenheilkunde, 1995
In 216 breast cancer patients, the prognostic value of current biological factors (c-erbB-2, EGF-receptor, p53, PCNA-proliferative fraction) was compared with that of conventionally histomorphologic features (histologic type, histologic grade, tumour size, hormonal receptor status).
I. Schönborn, C. Minguillon, W. Lichtenegger, W. Zschiesche, E. Spitzer   +4 more
openaire   +1 more source

Quantitative PCR Detection of c- erbB-2 Gene Amplification

2003
The association of c-erbB-2 oncogene amplification and prognostic factors was intensively studied in human gynecological carcinomas, especially in mammary carcinoma (1). Positive lymph nodes, estrogen and progesterone receptor negative tumors, and short survival time correlate with c-erbB-2 amplification.
K, Dobianer, M, Medl, J, Spona
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Gene Amplification of c- erbB-2 Detected by FISH

2003
In 1981, a novel transforming gene called neu, related to, but distinct from, the c-erbB protooncogene, was identified (1-3). In 1985, two groups independently isolated identical erbB-related genes from human DNA that they called HER-2 (4) and c-erbB-2 (5) located at chromosome band 17q11.2 and encoding a 185,000 Dalton tyrosine kinase (2,4).
S R, Young, W H, Liu, Z R, Wang
openaire   +2 more sources