Results 1 to 10 of about 66,098 (241)

Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase

1994
Tumorigenesis in model experimental systems involves multiple steps that include activation of cell growth and inactivation of inhibitory processes [1,2]. Tumor development in humans is thought to reflect the multiplicity of events in the accumulation of independent mutations that affect clonal growth of the cancerous cell [3].
I, Stancovski, M, Sela, Y, Yarden
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Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

Biochemistry, 1990
The erbB-1 and erbB-2 protooncogenes encode homologous membrane receptors that respectively bind epidermal growth factor (EGF) and a still incompletely characterized ligand. Binding of EGF to its receptor is known to increase tyrosine phosphorylation of the erbB-2/neu receptor in tumor cells. To investigate the mechanism of this transregulatory pathway,
R, Goldman, R B, Levy, E, Peles, Y, Yarden   +3 more
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Androgen receptor versus erbB-1 and erbB-2 expression in human prostate neoplasms

Oncology Reports, 2004
A subject of current interest, especially in the development of androgen refractory prostate cancer, is the androgen receptor (AR) activation by growth factor receptors. Here, we report our work on the measurement of AR mRNA and protein expression in benign prostatic hyperplasia (BPH) and prostatic carcinoma (PCA) and evaluation of the relationship ...
Magdalena, Brys, Magdalena, Stawinska, Marek, Foksinski, Andrzej, Barecki, Cezary, Zydek, Eugeniusz, Miekos, Wanda M, Krajewska   +6 more
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Abstract 4614: Progesterone receptor and ErbB-2 crosstalk in breast cancer

Cancer Research, 2010
Abstract Progesterone receptor (PR) and ErbB-2, a member of the ErbBs family of receptor tyrosine kinases, play key roles in breast cancer development. Here, we identified a new mechanism of PR and ErbB-2 interaction in breast cancer cells.
Wendy Béguelin, María C. Díaz Flaqué, Florencia Cayrol, Cecilia J. Proietti, Martín A. Rivas, Mercedes Tkach, Eduardo H. Charreau, Roxana Schillaci, Patricia V. Elizalde   +8 more
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The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998
Extensive clinical and biochemical evidence implicates ErbB-2, a transmembrane tyrosine kinase related to growth factor receptors, in the development, metastasis, and resistance to therapy of multiple, common human carcinomas. Previous attempts to uncover an ErbB-2-specific ligand led to isolation of the neuregulin (NRG) family, but these ligands, like
E, Tzahar, Y, Yarden
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p53, c-erbB-2 and the Epidermal Growth Factor Receptor in the Benign and Malignant Prostate

Journal of Urology, 1992
Expression of the p53, the epidermal growth factor receptor (c-erbB-1) and c-erbB-2 protein was studied in 34 men with benign prostatic hyperplasia and 29 men with locally advanced prostate cancer by means of an immuno-histochemical method. Strong staining for p53 was found in five of 29 prostate cancers (17%; mean 21% +/- 7% of malignant cells stained
K, Mellon, S, Thompson, R G, Charlton, C, Marsh, M, Robinson, D P, Lane, A L, Harris, C H, Horne, D E, Neal   +8 more
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Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer

Advances in Enzyme Regulation, 2009
In ERα-positive and HER2/neu overexpressing tumors, Notch signaling is partially suppressed and its role is limited by the overwhelming proliferative and survival effects of ERα-dependent and ErbB-2-dependent pathways. In triple-negative cancers, on the other hand, Notch signaling becomes a key mediator of proliferation, survival and possibly invasion.
RIZZO, Paola, Osipo C, Pannuti A, Golde T, Osborne B, Miele L.   +5 more
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Structure and Inhibition of the neu/erbB-2 Receptor.

1997
Abstract : Cancer results from a breakdown in the normal mechanisms which control the growth and division of cells. For many cells, the signals for initiating cell division are hormone molecules that bind to receptors on the surface of the cell. The signal is transmitted through the cell membrane by one or more receptor molecules.
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Oestrogen and vitamin D receptor (VDR) genotypes and the expression of ErbB-2 and EGF receptor in human rectal cancers

European Journal of Cancer, 2001
Oestrogen/oestrogen receptor (ER) and vitamin D/vitamin D receptor (VDR) systems have been implicated in the pathogenesis of colorectal cancers. The expression of erbB-2 and epidermal growth factor receptor (EGFR) in colorectal cancers has been suggested to have diagnostic and prognostic significance.
Speer, GĂĄbor, Cseh, KĂĄroly, Winkler, GĂĄbor, TakĂĄcs, IstvĂĄn, Barna, IstvĂĄn, Nagy, Zsolt, Lakatos, PĂŠter   +6 more
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Functional Sites of the erbB-2 Receptor and Its Activator Heregulin

2000
Abstract : Over expression of the erbB-2 (HER-2/neu) receptor occurs in up to 30% of human breast cancers and correlates with aggressive disease and poor prognosis for therapy and survival. The growth factor heregulin (HRG) binds to erbB-3 or erbB-4 receptors, promotes dimmer formation with erbB-2 and induces autophosphorylation and activation of erbB ...
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