Results 1 to 10 of about 13,620 (98)

Multi-Omics Data Analysis Uncovers Molecular Networks and Gene Regulators for Metabolic Biomarkers

Biomolecules, 2021
The insulin-like growth factors (IGFs)/insulin resistance (IR) axis is the major metabolic hormonal pathway mediating the biologic mechanism of several complex human diseases, including type 2 diabetes (T2DM) and cancers. The genomewide association study
Su Yon Jung
doaj   +1 more source

MiR-323a regulates ErbB3/EGFR and blocks gefitinib resistance acquisition in colorectal cancer

Cell Death and Disease, 2022
The rapid onset of resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) limits its clinical utility in colorectal cancer (CRC) patients, and pan-erb-b2 receptor tyrosine kinase (ErbB) treatment strategy may be the ...
Yuanzhou Zhang, Shunshun Liang, Bowen Xiao, Jingying Hu, Yechun Pang, Yuling Liu, Juan Yang, Junpin Ao, Lin Wei, Xiaoying Luo   +9 more
doaj   +1 more source

The Role of EGFR, Hepatocyte Growth Factor Receptor (c-Met), c-ErbB2 (HER2-neu) and Clinicopathological Parameters in the Pathogenesis and Prognosis of Chordoma [PDF]

Türk Patoloji Dergisi, 2017
Objective: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences.
Zeynep TOSUNER, Zeynep TOSUNER, Türker KILIÇ, Baran YILMAZ   +3 more
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Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice

Molecular Oncology, 2022
ERK3, officially known as mitogen‐activated protein kinase 6 (MAPK6), is a poorly studied mitogen‐activated protein kinase (MAPK). Recent studies have revealed the upregulation of ERK3 expression in cancer and suggest an important role for ERK3 in ...
Sreeram Vallabhaneni, Jian Liu, Marion Morel, Jixin Wang, Francesco J. DeMayo, Weiwen Long   +5 more
doaj   +1 more source

ERBB2-modulated ATG4B and autophagic cell death in human ARPE19 during oxidative stress.

PLoS ONE, 2019
Age-related macular degeneration (AMD) is an ocular disease with retinal degeneration. Retinal pigment epithelium (RPE) degeneration is mainly caused by long-term oxidative stress. Kinase activity could be either protective or detrimental to cells during
Shwu-Jiuan Sheu, Jiunn-Liang Chen, Youn-Shen Bee, Shi-Han Lin, Chih-Wen Shu   +4 more
doaj   +1 more source

Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants

Cancer Biology & Medicine
Targeted therapy is crucial for advanced colorectal cancer (CRC) positive for genetic drivers. With advances in deep sequencing technology and new targeted drugs, existing standard molecular pathological detection systems and therapeutic strategies can ...
Shuyi Chen, Jing Gu, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu   +4 more
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Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes

Frontiers in Cellular and Infection Microbiology
IntroductionDengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic.
Natasha M. Bourgeois, Natasha M. Bourgeois, Ling Wei, Nhi N. T. Ho, Nhi N. T. Ho, Maxwell L. Neal, Denali Seferos, Tinotenda Tongogara, Fred D. Mast, John D. Aitchison, John D. Aitchison, Alexis Kaushansky, Alexis Kaushansky, Alexis Kaushansky   +13 more
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HER3: Unmasking a twist in the tale of a previously unsuccessful therapeutic pursuit targeting a key cancer survival pathway

Genes and Diseases
HER3, formally referred to as ERB-B2 receptor tyrosine kinase 3, is a member of the ErbB receptor tyrosine kinases (also known as EGFR) family. HER3 plays a significant pro-cancer role in various types of cancer due to its overexpression and abnormal ...
Omkar Desai, Moeez Rathore, Christina S. Boutros, Michel'le Wright, Elizabeth Bryson, Kimberly Curry, Rui Wang   +6 more
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Full-length transcriptome atlas of gallbladder cancer reveals trastuzumab resistance conferred by ERBB2 alternative splicing

Signal Transduction and Targeted Therapy
Aberrant RNA alternative splicing in cancer generates varied novel isoforms and protein variants that facilitate cancer progression. Here, we employed the advanced long-read full-length transcriptome sequencing on gallbladder normal tissues, tumors, and ...
Ziyi Wang, Li Gao, Ziheng Jia, Liguo Liu, Ao Gu, Zhaonan Liu, Qin Zhu, Yichen Zuo, Mingjie Yang, Shijia Wang, Jiyao Ma, Jingyun Zhang, Shimei Qiu, Zhizhen Li, Jinghan Wang, Dongxi Xiang, Fatao Liu, Rong Shao, Yanjing Li, Maolan Li, Wu Wei, Yingbin Liu   +21 more
doaj   +1 more source

Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells [PDF]

Cancers, 2021
The epidermal growth factor receptor (EGFR) family member erb-b2 receptor tyrosine kinase 2 (ERBB2) is overexpressed in many types of cancers leading to (radio- and chemotherapy) treatment resistance, whereas the underlying mechanisms are still unclear. Autophagy is known to contribute to cancer treatment resistance.
Yongqiang Chen, Ruobing Wang, Shujun Huang, Elizabeth S. Henson, Jayce Bi, Spencer B. Gibson   +5 more
openaire   +2 more sources