Results 41 to 50 of about 15,844 (160)
Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 5029-5042, June 2026.ABSTRACT Aims The burden of chronic liver disease (CLD) is increasing. This study aims to identify protein markers for CLD and its progression, and develop a protein‐based risk prediction model. Materials and Methods We used proteome‐wide Mendelian randomization (MR), Bayesian colocalization and summary‐data‐based MR with proteomic data from deCODE ...
Xinxuan Li +9 more
wiley +1 more source
The Genetic Signature of Perineuronal Oligodendrocytes [PDF]
, 2008 Oligodendrocytes in the central nervous system can be categorized as precursors, myelin-forming, and non-myelinating perineuronal cells. The function of perineuronal oligodendrocytes is unknown; it was proposed that following injury, they may remyelinate
Dragan Maric +5 more
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The hidden impact of inter-individual genomic variations on cellular function [PDF]
, 2010 An analysis of the degree of genomic variation between two individual genomes suggests that there may be considerable biochemical differences among individuals.
Bolouri, Hamid, Georgescu, Constantin
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Cancer Science, Volume 117, Issue 5, Page 1235-1243, May 2026.RUNX‐dependent transcriptional control of SOS1 reinforces HER2–RAS signaling and may attenuate responses to HER2‐targeted therapies in HER2‐positive gastric cancer. ABSTRACT HER2‐positive gastric cancer represents a distinct molecular subtype characterized by chromosomal instability, variable HER2 amplification, and substantial intratumoral ...
Tatsuya Masuda +3 more
wiley +1 more source
Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway [PDF]
, 2012 [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis.
Antón-Aparicio, Luis M. +4 more
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Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.Abstract INTRODUCTION Alzheimer's disease (AD) is characterized by disrupted excitatory–inhibitory (E:I) balance and impaired synaptic function, yet current treatments fail to repair these fundamental circuit impairments. METHODS Human induced pluripotent stem cell‐derived post‐mitotic medial ganglionic eminence‐originated inhibitory neurons (MGE‐pINs)
Xinzhe Zhang +8 more
wiley +1 more source
Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data [PDF]
, 2014 Lung cancer leads cancer-related mortality worldwide. Non-small-cell lung cancer (NSCLC), the most prevalent subtype of this recalcitrant cancer, is usually diagnosed at advanced stages, and available systemic therapies are mostly palliative. The probing
Costa, D.B. +2 more
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Food Science &Nutrition, Volume 14, Issue 4, April 2026.Rosa damascena Mill. exhibits a broad spectrum of pharmacological activities mediated by its rich phytochemical profile. The plant enhances antioxidant defenses by increasing endogenous enzymes (CAT, SOD, GSH, GST, GPx, FRAP) and reducing oxidative stress markers (MDA, MPO).
Mahboobeh Ghasemzadeh Rahbardar +2 more
wiley +1 more source
Comparative gene expression profiling of ADAMs, MMPs, TIMPs, EMMPRIN, EGF-R and VEGFA in low grade meningioma [PDF]
, 2016 MMPs (matrix metalloproteinases), ADAMs (a disintegrin and metalloproteinase) and TIMPs (tissue inhibitors of metalloproteinases) are implicated in invasion and angiogenesis: both are tissue remodeling processes involving regulated proteolysis of the ...
Andrew J. Martin +49 more
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Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framework initiated by tissue injury and repair (TIAR), aberrant stem cell activation, or de novo metaplasia ...
Jiang Yang +6 more
wiley +1 more source