ABSTRACT Adenomyosis is a prevalent disorder of the archimetra, historically conflated with endometriosis but possessing a unique pathobiological trajectory. This review synthesises current molecular evidence to propose a unified mechanistic framework initiated by tissue injury and repair (TIAR), aberrant stem cell activation, or de novo metaplasia ...
Jiang Yang +6 more
wiley +1 more source
Envolvimento dos receptores B1 e B2 para as cininas na hiperatividade da bexiga urinária induzida por lesão medular em ratos [PDF]
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2011O envolvimento dos receptores B1 e B2 para as cininas em processos fisiopatológicos da bexiga ...
Forner, Stefânia
core
Post‐Translational Modifications in Animal Circadian Clocks
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley +1 more source
The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer [PDF]
HER-2 gene amplification or overexpression occurs in approximately 25 % of breast cancers, and trastuzumab (Tmab) is a monoclonal antibody currently used to treat patients with HER-2-overexpressing breast cancer.
Browne, Brigid
core
Multiple Receptor Tyrosine Kinases Regulate Dengue Infection of Hepatocytes
Thesis (Ph.D.)--University of Washington, 2023Currently, there is no way to constrain dengue virus (DENV) infections in the clinic. My dissertation work explored the hypothesis that host kinase regulators of DENV infection have the potential to be ...
Bourgeois, Natasha Marie
core
Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering [PDF]
During neuromuscular synaptogenesis, neurally released agrin induces aggregation and tyrosine phosphorylation of acetylcholine receptors (AChRs) by acting through both the receptor tyrosine kinase MuSK (muscle-specific kinase) and the AChR-associated ...
Mittaud, P +7 more
core +1 more source
Análise dos mecanismos envolvidos nas respostas contráteis induzidas por agonistas B1 e B2 para as cininas na íris de porco in vitro [PDF]
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Este trabalho demonstrou que a contração induzida pela BK na íris isolada de porco é mediada pelos receptores B2, com ...
El Sayah, Mariem
core
BMI and Breast Subcutaneous Fat
Objectives Obesity is closely associated with the occurrence and progression of breast cancer. While body mass index (BMI) is widely used to diagnose obesity, it has certain limitations. Subcutaneous fat thickness (SFT) also serves as an indicator of body composition. However, studies on breast SFT are scarce.
Shiyu Wang +5 more
wiley +1 more source
The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling [PDF]
The interferon alpha receptor (IFNAR) and T-cell receptor (TCR) are expressed upon the T-cell surface. The dimeric Class I interferon receptor is a cytokine receptor that recognises interferons such as IFNα.
Stevens, C.N., Stevens, C N
core
HER2 testing in breast cancer: Opportunities and challenges [PDF]
Human epidermal growth factor receptor 2 (HER2) is overexpressed in 15-25% of breast cancers, usually as a result of HER2 gene amplification. Positive HER2 status is considered to be an adverse prognostic factor. Recognition of the role of HER2 in breast
Lebeau, Annette, Annette Lebeau
core +1 more source

