Results 51 to 60 of about 15,844 (160)

Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]

, 2016
Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja, Lechpammer, Mirna, Pećina-Šlaus, Nives   +2 more
core   +2 more sources

Post‐Translational Modifications in Animal Circadian Clocks

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley   +1 more source

Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts [PDF]

, 2015
Aims. Protein kinases are potential therapeutic targets for heart failure, but most studies of cardiac protein kinases derive from other systems, an approach that fails to account for specific kinases expressed in the heart and the contractile ...
Alessi, Angela Clerk, Bruce G. Allen, Clerk, George Vaniotis, Lompré, Michelle A. Hardyman, Peter H. Sugden, Sally A. Osborne, Sam J. Leonard, Stephen J. Fuller, Stokoe   +11 more
core   +1 more source

A large-scale proteomic analysis of human embryonic stem cells [PDF]

, 2007
Background Much of our current knowledge of the molecular expression profile of human embryonic stem cells (hESCs) is based on transcriptional approaches.
Thomas C Schulz, Anna Maria Swistowska, Ying Liu, Andrzej Swistowski, Gail Palmarini, Sandii N Brimble, Eric Sherrer, Allan J Robins, Mahendra S Rao, Xianmin Zeng, Schulz, Thomas   +10 more
core   +1 more source

BMI and Breast Subcutaneous Fat

Journal of Ultrasound in Medicine, Volume 45, Issue 3, Page 599-610, March 2026.
Objectives Obesity is closely associated with the occurrence and progression of breast cancer. While body mass index (BMI) is widely used to diagnose obesity, it has certain limitations. Subcutaneous fat thickness (SFT) also serves as an indicator of body composition. However, studies on breast SFT are scarce.
Shiyu Wang, Jin Zhou, Yunxia Huang, Dongdong Zheng, Ruoqing Hou, Shichong Zhou   +5 more
wiley   +1 more source

Aumolertinib with carboplatin–pemetrexed versus aumolertinib for nonsmall cell lung cancer with EGFR and concomitant tumor suppressor genes (ACROSS2): An open‐label, multicenter, randomized phase 3 study

CA: A Cancer Journal for Clinicians, Volume 76, Issue 2, March/April 2026.
ABSTRACT Third‐generation epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) are standard first‐line therapy for advanced, EGFR‐mutated nonsmall cell lung cancer (NSCLC). However, their benefit is limited in patients who have co‐existing tumor suppressor gene (TSG) mutations, highlighting a need for intensified strategies to ...
Jian‐Chun Duan, Jia Zhong, Bo‐Yang Sun, Wen‐Hua Zhao, Lin Wu, Kai‐Lun Fei, Qian Chu, Qi‐Sen Guo, Qi‐Bin Song, Yan Yu, Da‐Xing Zhu, Xin‐Yan Liu, Jun Zhao, Zhi‐Xiang Zhan, Shi Li, Lei Nie, Jie Lin, Xiao‐Dong Peng, Dian‐Sheng Zhong, Jin Zhou, Li‐Hua Li, Yun‐Fang Chen, Chen Hu, Tony Mok, Zhi‐Jie Wang, Jie Wang   +25 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Insights Into circRNA‐Mediated Lipid Metabolism in Cancer Progression

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been
Zhiwei Miao, Jingjing Cao, Xiaoyu Wang, Chunyu Zhang, Tongguo Shi   +4 more
wiley   +1 more source

Alteration of AKT Activity Increases Chemotherapeutic Drug and Hormonal Resistance in Breast Cancer yet Confers an Achilles Heel by Sensitization to Targeted Therapy [PDF]

, 2008
The PI3K/PTEN/Akt/mTOR pathway plays critical roles in the regulation of cell growth. The effects of this pathway on drug resistance and cellular senescence of breast cancer cells has been a focus of our laboratory.
Adachi, Agostino Tafuri, Alberto M. Martelli, Allan, Andrzej Dzugaj, Aplin, Arcinas, Bader, Barnes, Blagosklonny, Blalock, Blalock, Brian D. Lehmann, Brooks, Brunet, Camilla Evangelisti, Cardone, Carpten, Carter, Centers for Disease Control and Prevention, Chang, Chang, Clark, Cocco, Coutant, Damen, Dan, David M. Terrian, Davies, Davis, Davis, DeGraffenried, del Peso, Delaney, Deng, Deng, Deng, Devarajan, Dijkers, Domina, Drexler, Du, Dufner, Eblen, Edinger, Ellis W.T. Wong, Elmore, Engleman, Enmark, Evangelisti, Fasco, Feilotter, Fingar, Flotho, Franca Stivala, Francesca Chiarini, Fry, Fu, Fuqua, Gao, Garcia, Gardai, Giles, Giovanni Ligresti, Gottlieb, Greenman, Hall-Jackson, Harada, Harada, Hay, Heimbrook, Hochhaus, Hollestelle, Howe, Howe, Hresko, Hu, Iijima, Inhorn, Jackson R. Taylor, James A. McCubrey, Jemal, Jia, Jin, Jonassen, Jörg Bäsecke, Kang, Karin, Kavanaugh, Kirkegaard, Konecny, Kornblau, Kristin M. Stadelman, Lanfrancone, Lange-Carter, Lawlor, Lee, Lee, Lehmann, Leslie, Lespagnard, Ley, Leygue, Li, Li, Li, Liang, Liaw, Linda S. Steelman, Lioubin, Lu, Luo, Lynch, Lyons, Ma, Madrid, Mahalingam, Mahimainathan, Manning, Marais, Marais, Marani, Marek Zarzycki, Martelli, Martelli, Martin, Mason, Massimo Libra, Matsuguchi, Mayo, Mayo, Mazzucchelli, McCubrey, McCubrey, McCubrey, Medema, Melissa L. Sokolosky, Michele Milella, Mobasheri, Mukherjee, Muraille, Myers, Nagata, Nakae, Navolanic, Negin Misaghian, Nimwegen, Noguchi, Obexer, Ohren, Okuda, Ozes, Panwalkar, Pao, Pao, Patrick M. Navolanic, Persad, Ponti, Poola, Poola, Qi, Raftopoulou, Rao, Rhei, Richard A. Franklin, Robinson, Rodriguez-Viciana, Romanelli, Romashkova, Samuels, Scheid, Sequist, Shaw, Shelton, Shelton, Shelton, Shelton, Shen, Shimada, Shishodia, Singh, Songyang, Sordella, Soule, Steck, Steelman, Steelman, Stefan Horn, Stephen L. Abrams, Stirewalt, Tai, Tamburini, Tamura, Tauchi, Taylor, Thomas, Tokunaga, Tokunaga, Tortora, Tresini, Troppmair, Trotman, Troussard, Tsutsui, Twiddy, Vogt, Wang, Wang, Wang, Wang, Weber, Wendel, Weng, Weng, Weston, William H. Chappell, Witzig, Xing, Xu, Xu, Yeh, Yoshida, You, Yu, Yu, Zhang, Zhou   +226 more
core   +1 more source

Racial/Ethnic Differences in Pathologic Complete Response to Neoadjuvant Chemotherapy and Survival Among Early-Stage, Erb-B2 Receptor Tyrosine Kinase 2-Low Breast Cancer Patients

Journal of Breast Cancer
Racial/ethnic differences in pathologic complete response (pCR), and in overall survival (OS) by pCR status, among early-stage, erb-b2 receptor tyrosine kinase 2 (ERBB2)-low breast cancer patients after neoadjuvant chemotherapy (NACT) are unknown. Data were from the 2010-2020 National Cancer Database that included Asian/Pacific Islander (API), American
Jincong Q. Freeman, James L. Li, Olasubomi J. Omoleye   +2 more
openaire   +2 more sources