Results 51 to 60 of about 13,813 (161)

Racial/Ethnic Differences in Pathologic Complete Response to Neoadjuvant Chemotherapy and Survival Among Early-Stage, Erb-B2 Receptor Tyrosine Kinase 2-Low Breast Cancer Patients

Journal of Breast Cancer
Racial/ethnic differences in pathologic complete response (pCR), and in overall survival (OS) by pCR status, among early-stage, erb-b2 receptor tyrosine kinase 2 (ERBB2)-low breast cancer patients after neoadjuvant chemotherapy (NACT) are unknown. Data were from the 2010-2020 National Cancer Database that included Asian/Pacific Islander (API), American
Jincong Q. Freeman, James L. Li, Olasubomi J. Omoleye   +2 more
openaire   +2 more sources

Aumolertinib with carboplatin–pemetrexed versus aumolertinib for nonsmall cell lung cancer with EGFR and concomitant tumor suppressor genes (ACROSS2): An open‐label, multicenter, randomized phase 3 study

CA: A Cancer Journal for Clinicians, Volume 76, Issue 2, March/April 2026.
ABSTRACT Third‐generation epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) are standard first‐line therapy for advanced, EGFR‐mutated nonsmall cell lung cancer (NSCLC). However, their benefit is limited in patients who have co‐existing tumor suppressor gene (TSG) mutations, highlighting a need for intensified strategies to ...
Jian‐Chun Duan, Jia Zhong, Bo‐Yang Sun, Wen‐Hua Zhao, Lin Wu, Kai‐Lun Fei, Qian Chu, Qi‐Sen Guo, Qi‐Bin Song, Yan Yu, Da‐Xing Zhu, Xin‐Yan Liu, Jun Zhao, Zhi‐Xiang Zhan, Shi Li, Lei Nie, Jie Lin, Xiao‐Dong Peng, Dian‐Sheng Zhong, Jin Zhou, Li‐Hua Li, Yun‐Fang Chen, Chen Hu, Tony Mok, Zhi‐Jie Wang, Jie Wang   +25 more
wiley   +1 more source

Mecanismos envolvidos no efeito modulatório de citocinas pró-inflamatórias sobre as respostas mediadas pelos receptores B1 e B2 para as cininas na pata de rato. [PDF]

, 2001
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Estudo do efeito do tratamento local com [citocinas pró-inflamatórias] sobre as respostas mediadas pelos [receptores B1 e ...
Campos, Maria Martha
core  

Profiling human breast tumor biopsies. gene expression changes associated with ERBB2 status and prognosis, and possible implications for molecular breast cancer classification in the clinic [PDF]

, 2009
Breast cancer is the most common malignancy in women in Western countries, and has proven to be a very heterogeneous disease both on the biological and clinical level.
Urban, Patrick
core   +1 more source

Multiple System Atrophy (Cerebellar Type) With Overlapping Progressive Muscular Atrophy Features and Genetic Erb-B2 Receptor Tyrosine Kinase 4 (ERBB4) Amyotrophic Lateral Sclerosis Variant: A Case Report

Cureus
Multiple system atrophy (MSA) is a progressive disease with Parkinsonism, dysautonomia, and cerebellar symptoms wherein patients can present with a broad range of confusing and overlapping findings attributable to various neuroanatomical substrates.
Panganiban, Enrique Lorenzo C, Rosales, Raymond L   +1 more
openaire   +2 more sources

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Structure and molecular interaction analysis of monoclonal antibodies in complex with receptor tyrosine kinases

, 2010
Misregulated receptor tyrosine kinases (RTKs), i.e. the epidermal growth factor receptor EGFR or the insulin-like growth factor receptor 1 (IGF-1R), can be involved in the development of cancer.
Schmiedel, Judith
core  

Insights Into circRNA‐Mediated Lipid Metabolism in Cancer Progression

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been
Zhiwei Miao, Jingjing Cao, Xiaoyu Wang, Chunyu Zhang, Tongguo Shi   +4 more
wiley   +1 more source

Gonadotropin-releasing hormone alleviates chronic pain-related depression in male mice by rebalancing the anterior cingulate cortex excitatory-inhibitory processes via the protein kinase C/Erb-B2 receptor tyrosine kinase 4 pathway

Brain Communications
Abstract Depression is a common comorbidity of chronic pain. Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) expressed in the central nervous system are involved in non-reproductive functions. Herein, we aimed to elucidate the role and mechanism of action of GnRH in pain-related depression like behaviour in a mouse ...
Yanmei Huang, Yunfeng Chen, Xueqin Liu, Yang Xu, Ling Chen, Wenyu Cao, Xiaolin Zhong   +6 more
openaire   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source