Results 61 to 70 of about 15,844 (160)

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source

Genome-wide characterization of pancreatic adenocarcinoma patients using next generation sequencing [PDF]

, 2012
Pancreatic adenocarcinoma (PAC) is among the most lethal malignancies. While research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult and the majority of currently available therapies provide ...
Aldrich, Jessica, Baker, Angela, Barrett, Michael, Benson, Hollie, Borad, Mitesh J., Braggio, Esteban, Carpten, John, Christoforides, Alexis, Craig, David W., Demeure, Michael J., Egan, Jan B., Fonseca, Rafael, Han, Haiyong, Hostetter, Galen H., Izatt, Tyler, Kiefer, Jeffrey A., Kurdoglu, Ahmet, Lake, Douglas, Legendre, Christophe, Liang, Winnie S., Phillips, Lori, Posner, Richard, Ramanathan, Ramesh K., Sinari, Shripad, Stewart, A. Keith, Stites, Edward C., Tembe, Waibhav, Von Hoff, Daniel, Weiss, Glen J.   +28 more
core   +7 more sources

Epidermal Growth Factor Receptor (EGFR) as a Prognostic Marker: an Immunohistochemical Study on 315 Consecutive Breast Carcinoma Patients [PDF]

, 2002
Objective: To assess the independent and interdependent prognostic value of epidermal growth factor receptor (EGFR) in carcinoma of breast in female population.
Aziz, S. A., Kayani, N., Khan, S., Pervez, Shahid, Rahbar, M. H.   +4 more
core   +1 more source

Farnesyltransferase inhibitors and human malignant pleural mesothelioma: a first-step comparative translational study. [PDF]

, 2005
It is known that the potential clinical use of farnesyltransferase inhibitors (FTI) could be expanded to include cancers harboring activated receptor tyrosine kinases.
Cardaci V, Catassi A, Cesario A, Dominioni L, Festi L, Galetta D, Granone P, Imperatori A, Margaritora S, Pericelli A, Porziella V, Russo P.   +11 more
core   +1 more source

Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments

The FEBS Journal, Volume 293, Issue 1, Page 26-41, January 2026.
Intracellular communication controls the processing of generated signals so that every cell type can successfully respond. The extracellular matrix (ECM) is a fundamental regulator of cell communication and signaling through the strict orchestration and functions of its bioactive components.
Zoi Piperigkou, Sylvia Mangani, Nikolaos E. Koletsis, Christos Koutsakis, Nicholas S. Mastronikolis, Marco Franchi, Nikos K. Karamanos   +6 more
wiley   +1 more source

Antisense oligonucleotides targeting valosin‐containing protein ameliorate muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
Multisystem proteinopathy 1 (MSP1), caused by gain‐of‐function VCP variants, leads to multisystem degeneration. Using VCP patient‐derived hiPSCs, skeletal muscle progenitor cells were generated to evaluate antisense oligonucleotide (ASO) therapy.
Pallabi Pal, Michele Carrer, Lan Weiss, Olga G. Jaime, Cheng Cheng, Alyaa Shmara, Victoria Boock, Danae Bosch, Marwan Youssef, Yasamin Fazeli, Megan Afetian, Tamar R. Grossman, Michael R. Hicks, Paymaan Jafar‐nejad, Virginia Kimonis   +14 more
wiley   +1 more source

Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer [PDF]

, 2016
Gene fusions are common cancer-causing mutations, but the molecular principles by which fusion protein products affect interaction networks and cause disease are not well understood.
Babu, M. Madan, Buljan, Marija, Flock, Tilman, Gough, Julian, Latysheva, Natasha S., Maddox, Louis, Oates, Matt E., Weatheritt, Robert J.   +7 more
core   +3 more sources

Evolving Landscape of Precision Medicine in Bladder Cancer: From Challenges to Clinical Impact

iLABMED, Volume 3, Issue 4, Page 427-447, December 2025.
Evolving Landscape of Precision Medicine in Bladder Cancer. Image created with BioRender.com. ABSTRACT Bladder cancer (BCa) remains one of the most challenging urological malignancies to treat because of its marked molecular heterogeneity, high recurrence rates, and variable therapeutic responses.
Ting Ye, Javeria Qadir, Guangjie Peng, Liyuan Liu, Liang Cheng   +4 more
wiley   +1 more source

Metabolomics of Disease Resistance in Crops [PDF]

, 2015
Plants are continuously exposed to the attack of invasive microorganisms, such as fungi or bacteria, and also viruses. To fight these attackers, plants develop different metabolic and genetic responses whose final outcome is the production of toxic
Arbona, Vicent, Gomez-Cadenas, Aurelio
core   +2 more sources

Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs. [PDF]

, 2020
Many crucial cardiovascular adaptations occur in the body during pregnancy to ensure successful gestation. Maladaptation of the cardiovascular system during pregnancy can lead to complications that promote cardiac dysfunction and may lead to heart ...
Aryan, Laila, Eghbali, Mansoureh, Medzikovic, Lejla, Umar, Soban   +3 more
core