ErbB2 Dephosphorylation and Anti-Proliferative Effects of Neuregulin-1 in ErbB2-Overexpressing Cells; Re-evaluation of Their Low-Affinity Interaction [PDF]
, 2013 Neuregulin-1 binds to ErbB3 and ErbB4 and regulates cancer proliferation and differentiation. Neuregulin-1 had been suggested to also react with ErbB2, but this argument becomes controversial.
Araki Kazuaki +10 more
core +1 more source
Clinical and multiple gene expression variables in survival analysis of breast cancer: Analysis with the hypertabastic survival model [PDF]
, 2012 BACKGROUND: We explore the benefits of applying a new proportional hazard model to analyze survival of breast cancer patients. As a parametric model, the hypertabastic survival model offers a closer fit to experimental data than Cox regression, and ...
Hong Li +4 more
core +1 more source
Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas [PDF]
, 2012 Background Gliomas are the most common neoplasm of the brain. High-grade gliomas often resist treatment even with aggressive surgical resection and adjuvant radiation and chemotherapy.
Éva Gömöri +3 more
core +1 more source
ميزان بروزغشايی پروتئين HER2 در سرطان سلول قاعدهای پوست در مقايسه با پوست طبيعی حاشيهی تومور به روش ايمونوهيستوشيمی [PDF]
, 2013 زمينه و هدف: سرطان سلول قاعدهای پوست ((Basal Cell Carcinoma-BCC شايعترين سرطان بدن و پوست میباشد. تشخيص در مراحل اوليه میتواند با درمان قطعی همراه باشد ولی برخی از انواع BCC، به خصوص نوع انفلتراتيو قادر به تهاجم عمقی، عودهای مکرر و تخريب وسيع بافتی ...
اسدی کنی, زهرا +3 more
core
Background : Of the four epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases, ERBB3 is one of them. It is known to form active heterodimers with other members of the ERBB family, most notably the ligand binding-impaired ERBB2.
openaire +2 more sources
Methods for Treating Congestive Heart Failure [PDF]
, 2010 The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin ...
Kelly, Ralph +3 more
core +2 more sources
Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells [PDF]
, 2017 Estrogen receptors display high levels of promiscuity in accommodating a wide range of ligand structures, but the functional consequence of changing receptor conformations in complex with distinct agonists is highly controversial. To determine variations
Buterin, Tonko +2 more
core
Methods for Treating Congestive Heart Failure [PDF]
The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin ...
Kelly, Ralph +3 more
core +1 more source
European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. [PDF]
, 2019 Background: Cisplatin, a powerful antitumor agent, causes formation of DNA adducts, and activation of apoptotic pathways. Presently, cisplatin resistance develops in up to 70% of patients but the underlying molecular mechanism(s) are unclear and there ...
Abedi, Sina +13 more
core +1 more source
Caveolin-1, breast cancer and ionizing radiation [PDF]
, 2015 Breast cancer (BC) recovery has increased in recent years thanks to efforts of Omics-based research in this field. However, despite the important results obtained, BC remains a complex multifactorial pathology that is difficult to treat appropriately ...
Bravata', V. +6 more
core