Results 71 to 80 of about 13,813 (161)

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 / erb-b2 receptor tyrosine kinase 3 (ERBB3) : Machine learning discoveries of 2nd order synergy in Meningiomas

Background : Of the four epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases, ERBB3 is one of them. It is known to form active heterodimers with other members of the ERBB family, most notably the ligand binding-impaired ERBB2.
openaire   +2 more sources

Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor

, 2008
Includes abstract.Includes bibliographical references (p. 179-202).The pituitary gonadotrophin releasing hormone (GnRH) receptor regulates reproduction by activation of Gq/11 proteins.
Coetsee, Marla Catherine
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Control of DNA replication by NCOA4 protein in HeLa cells

, 2009
This dissertation is focused on the functional characterization of NCOA4 protein, and in particular on its role in controlling DNA replication in HeLa cells.
Provitera, Livia
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Deregulated ephrin-B2 expression in the mammary gland interferes with the development of both the glandular epithelium and vasculature and promotes metastasis formation

, 2009
Eph receptor tyrosine kinases and their membrane-bound ephrin ligands play key roles during morphogenesis and adult tissue homeostasis. Receptor-ligand interactions result in forward and reverse signalling from the receptor and ligand respectively.
Munarini, Nadia, Stirnimann, Christoph, Zürcher, Gisela, Rohrbach, Valeria, Djonov, Valentin, Andres, Anne-Catherine, Custer, Domenica, Ziemiecki, Andrew, Haldimann, Mirjam   +8 more
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Graded and Lamina-Specific Distributions of Ligands of EphB Receptor Tyrosine Kinases in the Developing Retinotectal System

, 1997
Molecular gradients have been postulated to control the topographic mapping of retinal axons in their central targets. Based initially on their expression patterns, and more recently on functional studies, members of the EphA subfamily of receptor ...
O'Leary, Dennis D. M., Braisted, Janet E., Friedman, Glenn C., Anderson, David J., O'leary, Dennis D.M., McLaughlin, Todd, Wang, Hai U.   +6 more
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Kinases and pathways affected by ex-vivo vemurafenib in BRAF(V600E) melanoma tumors.

, 2013
In dark blue color are array substrates representing kinases distinguishing between BRAF wild-type and BRAF(V600E) tumors ...
Karianne Risberg (207221), Anne H. Ree (452292), Vessela Kristensen (25468), Jürgen Geisler (3478049), Christian Busch (157291), Per E. Lønning (158245), Andliena Tahiri (452291), Kathrine Røe (411861), Rik de Wijn (115101)   +8 more
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Off-target effects of statins [Elektronisk resurs] : molecular mechanisms, side effects and the emerging role of kinases

Statins are one of the most important classes of drugs. In this analytical review, we elucidate the intricate molecular mechanisms and toxicological rationale regarding both the on- (targeting 3-hydroxy-3-methylglutaryl-coenzyme A reductase [HMGCR]) and ...
Lagunas-Rangel, Francisco Alejandro,, Williams, Michael J., Alsehli, Ahmed M.,, Lagunas-Rangel, Francisco Alejandro, Liepinsh, Edgars, Fredriksson, Robert, Jonsson, Jörgen, Jonsson, Jörgen,, Schiöth, Helgi, Alsehli, Ahmed M., Williams, Michael J.,, Fredriksson, Robert,, Schiöth, Helgi,, Dambrova, Maija   +13 more
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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

, 2010
In development, tissue regeneration or certain diseases, angiogenic growth leads to the expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell proliferation as well as angiogenic sprouting, in which a subset of cells ...
Nobes, Catherine D, Nakayama, M, Benjamin, L.E, Bochenek, M.L, Davy, A, Bochenek, Magdalena L, Deutsch, Urban, Pitulescu, Mara E, Davy, Alice, Adams, Ralf H, Schmidt, Tim S, Deutsch, U, Schmidt, T.S, Sakakibara, Akira, Adams, Susanne, Lüthi, Urs, Pitulescu, M.E, Mäkinen, Taija, Wang, Y, Adams, R.H, Lüthi, U, Adams, S, Nakayama, Masanori, Barberis, Alcide, Mäkinen, T, Wang, Yingdi, Barberis, A, Benjamin, Laura E, Nobes, C.D, Sakakibara, A   +29 more
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Monitoring interactions between receptor tyrosine kinases and their downstream effector proteins in living cells using bioluminescence resonance energy transfer

, 2007
A limited number of whole-cell assays allow monitoring of receptor tyrosine kinase (RTK) activity in a signaling pathway-specific manner. We present the general use of the bioluminescence resonance energy transfer (BRET) technology to quantitatively ...
Timothy A Sweetnam, Esther C Reding, Philip K Tan, Norman R Nash, Jean Wang, Pey-Lih H Littler, Hans H Schiffer, William Keefe, Mark R Brann, Kenneth K Wong, Fabrice Piu   +10 more
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Diverse Roles for the Eph Family of Receptor Tyrosine Kinases in Carcinogenesis

, 2002
The Eph family of receptor tyrosine kinases and their cell-presented ligands, the ephrins, are frequently overexpressed in a wide variety of cancers, including breast, small-cell lung and gastrointestinal cancers, melanomas, and neuroblastomas.
Bergeman, Andrew, Nakamoto, Masaru
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