Results 21 to 30 of about 15,844 (160)

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties [PDF]

, 2013
Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl transfer, termed pseudokinases, have emerged as important signalling domains across all kingdoms of life.
Babon, Jeffrey J., Bailey, Fiona P., Chen, Kelan, Daly, Roger J., Elowe, Sabine, Eyers, Patrick A., Fukuda, Koichi, Gee, Christine L., Hammaren, Henrik, Jura, Natalia, Liu, Ling, Lucet, Isabelle S., Manning, Gerard, Mudgett, Mary Beth, Murphy, James M., Nimchuk, Zachary, Qin, Jun, Reese, Michael L., Silvennoinen, Olli, Tripaydonis, Anne, Ungureanu, Daniela, Varghese, Leila N., Young, Samuel N., Zhang, Qingwei   +23 more
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Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy [PDF]

, 2013
BACKGROUND: Aberrant neuron/glia interactions can contribute to a variety of neurodegenerative diseases and we have previously demonstrated that enhanced activation of Erb B2, which is a member of the epidermal growth factor receptor (EGFR) family, can ...
Pan Pan, Rick T Dobrowsky
core   +1 more source

Adaptive resistance to RAF inhibitors in melanoma. [PDF]

, 2014
The discovery of activating mutations in BRAF at high frequency in cutaneous melanoma opened the door to new treatment options, which have resulted in significantly better patient outcomes.
Abel, Basile, Chakrabarty, Chandarlapaty, Corcoran, Curry, Das Thakur, Davies, Dykens, Flaherty, Gala, Gopal, Haq, Hartsough, Hartsough, Heidorn, Kim, Kolch, Kopetz, Lito, Montero-Conde, Moreno-Sánchez, Morrison, Muranen, Nazarian, Owens, Papa, Paraiso, Poulikakos, Prahallad, Pratilas, Roesch, Salama, Sergina, Serra, Shao, Sharma, Shi, Shi, Smalley, Sosman, Sun, Villanueva, Warburg, Wilson, Yan   +45 more
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Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis [PDF]

, 2012
The prognostic importance of examining ErbB receptor family expression in human bladder cancer remains uncertain. Using published evidence, we examined the clinical value and the updated results of clinical trials targeting ErbB receptor family members ...
Hong-Lin Cheng, Nan-Haw Chow, Tzong-Shin Tzai, Yuh-Shyan Tsai   +3 more
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Understanding drugs in breast cancer through drug sensitivity screening [PDF]

, 2015
With substantial numbers of breast tumors showing or acquiring treatment resistance, it is of utmost importance to develop new agents for the treatment of the disease, to know their effectiveness against breast cancer and to understand their ...
Foekens, J.A. (John), Göhlmann, H.W.H. (Hinrich W. H.), Heine, A.A.J. (Anouk), Jager, A. (Agnes), Martens, J.W.M. (John), Ozturk, B. (Bahar), Prager-van der Smissen, W.J.C. (Wendy), Smid, M. (Marcel), Uhr, K. (Katharina)   +8 more
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ERBB2-modulated ATG4B and autophagic cell death in human ARPE19 during oxidative stress.

PLoS ONE, 2019
Age-related macular degeneration (AMD) is an ocular disease with retinal degeneration. Retinal pigment epithelium (RPE) degeneration is mainly caused by long-term oxidative stress. Kinase activity could be either protective or detrimental to cells during
Shwu-Jiuan Sheu, Jiunn-Liang Chen, Youn-Shen Bee, Shi-Han Lin, Chih-Wen Shu   +4 more
doaj   +1 more source

Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer. [PDF]

, 2016
Genomic loss of chromosome (chr) 8p21 region, containing prostate-specific NKX3.1 gene, is a frequent alteration of the prostate cancer (PCa) oncogenome.
Bucay, Nathan, Dahiya, Rajvir, Deng, Guoren, Greene, Kirsten, Majid, Shahana, Saini, Sharanjot, Sekhon, Kirandeep, Shahryari, Varahram, Tabatabai, Z Laura, Tanaka, Yuichiro, Yamamura, Soichiro   +10 more
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Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants

Cancer Biology & Medicine
Targeted therapy is crucial for advanced colorectal cancer (CRC) positive for genetic drivers. With advances in deep sequencing technology and new targeted drugs, existing standard molecular pathological detection systems and therapeutic strategies can ...
Shuyi Chen, Jing Gu, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu   +4 more
doaj   +1 more source

Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes

Frontiers in Cellular and Infection Microbiology
IntroductionDengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic.
Natasha M. Bourgeois, Natasha M. Bourgeois, Ling Wei, Nhi N. T. Ho, Nhi N. T. Ho, Maxwell L. Neal, Denali Seferos, Tinotenda Tongogara, Fred D. Mast, John D. Aitchison, John D. Aitchison, Alexis Kaushansky, Alexis Kaushansky, Alexis Kaushansky   +13 more
doaj   +1 more source

Pathways for aberrant angiogenesis in pancreatic cancer [PDF]

, 2003
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease. Althoughthe specific mechanisms that dictate its biological aggressiveness are notclearly established, it is characterized by a variety of molecularalterations as well as by the ...
M Korc
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