Erb-b2 receptor tyrosine kinases

Results 11 to 20 of about 13,620 (98)

Computer-aided scoring of erb-b2 receptor tyrosine kinase 2 (HER2) gene amplification status in breast cancer

Journal of Pathology Informatics, 2022
Identification of HER2 protein overexpression and/or amplification of the HER2 gene are required to qualify breast cancer patients for HER2 targeted therapies. In situ hybridization (ISH) assays that identify HER2 gene amplification function as a stand-alone test for determination of HER2 status and rely on the manual quantification of the number of ...
Alyson Yoder +12 more
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Discordance between Immunohistochemistry and Erb-B2 Receptor Tyrosine Kinase 2 mRNA to Determine Human Epidermal Growth Factor Receptor 2 Low Status for Breast Cancer

The Journal of Molecular Diagnostics, 2022
Novel human epidermal growth factor receptor 2 (HER2)-directed antibody-drug conjugates have demonstrated efficacy in HER2-low expressing breast cancers, which are currently defined as those with immunohistochemistry (IHC) scores of 1+ or 2+ with a negative in situ hybridization assay. However, current HER2 testing methods are designed to identify HER2-
Keying Xu +11 more
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ATG12-dependent autophagy is promoted by the erb-b2 receptor tyrosine kinase 2 (ERBB2), contributing to breast cancer cells' resistance to treatment

International journal of health sciences, 2022
The erb-b2 receptor tyrosine kinase 2 (ERBB2), a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in a variety of malignancies (radio- and chemotherapy)., While the fundamental processes are yet unknown, treatment resistance does. Autophagy is well-known.to increase resistance to cancer therapy.
May Jaleel Abed, Abdalkhaliq A. Abdalameer +1 more
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Expression of the Tyrosine Kinase Activity Growth Factor Receptors (EGFR, ERB B2, ERB B3) in Colorectal Adenocarcinomas and Adenomas

Tumor Biology, 2000
The overexpression of three growth factor receptors: epidermal growth factor receptor (EGFR), ERB B2 and ERB B3 was evaluated immunohistochemically in 77 malignant and 15 benign colorectal neoplasms considering clinicopathological variables (histological structure, grade of differentiation, tumor localization, clinical stage of the disease).
I, Porebska, A, Harlozińska, T, Bojarowski +2 more
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Erb-b2 Receptor Tyrosine Kinase 2 Interaction with Growth Factor Receptor Bound Protein 7 Acts as a Molecular Switch to Activate Non-Small Cell Lung Cancer

Biomedical and Biotechnology Research Journal (BBRJ), 2023
Background: The progression and metastasis of non small cell lung cancer (NSCLC) are considered a very complex process as it involves aberrations of multiple genes and cellular pathways. Genes which are differentially expressed in NSCLC have multi interactions with other genes, which can promote the carcinogenesis.
Anita Chauhan, Seema Kalra
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Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells

Oncology Reports, 2020
The oncogenic role of Erb‑B2 Receptor Tyrosine Kinase 2 (ERBB2) has been identified in several types of cancer, but less is known on its function and mechanism of action in cervical cancer cells. The present study employed a multipronged approach to investigate the role of ERBB2 in cervical cancer.
Liu, Hongli +10 more
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A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines [PDF]

Molecular Pharmacology, 2013
Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole-genome loss-of-function screen to identify genes whose knockdown potentiated the inhibitory effect of the FGFR inhibitor ...
Katherine R, Singleton +8 more
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Racial/Ethnic Differences in Pathologic Complete Response to Neoadjuvant Chemotherapy and Survival Among Early-Stage, Erb-B2 Receptor Tyrosine Kinase 2-Low Breast Cancer Patients

Journal of Breast Cancer
Racial/ethnic differences in pathologic complete response (pCR), and in overall survival (OS) by pCR status, among early-stage, erb-b2 receptor tyrosine kinase 2 (ERBB2)-low breast cancer patients after neoadjuvant chemotherapy (NACT) are unknown. Data were from the 2010-2020 National Cancer Database that included Asian/Pacific Islander (API), American
Jincong Q. Freeman, James L. Li, Olasubomi J. Omoleye +2 more
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Multiple System Atrophy (Cerebellar Type) With Overlapping Progressive Muscular Atrophy Features and Genetic Erb-B2 Receptor Tyrosine Kinase 4 (ERBB4) Amyotrophic Lateral Sclerosis Variant: A Case Report

Cureus
Multiple system atrophy (MSA) is a progressive disease with Parkinsonism, dysautonomia, and cerebellar symptoms wherein patients can present with a broad range of confusing and overlapping findings attributable to various neuroanatomical substrates.
Panganiban, Enrique Lorenzo C, Rosales, Raymond L +1 more
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Gonadotropin-releasing hormone alleviates chronic pain-related depression in male mice by rebalancing the anterior cingulate cortex excitatory-inhibitory processes via the protein kinase C/Erb-B2 receptor tyrosine kinase 4 pathway

Brain Communications
Abstract Depression is a common comorbidity of chronic pain. Gonadotropin-releasing hormone (GnRH) and its receptor (GnRHR) expressed in the central nervous system are involved in non-reproductive functions. Herein, we aimed to elucidate the role and mechanism of action of GnRH in pain-related depression like behaviour in a mouse ...
Yanmei Huang +6 more
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