Results 11 to 20 of about 15,844 (160)

Expression of the Tyrosine Kinase Activity Growth Factor Receptors (EGFR, ERB B2, ERB B3) in Colorectal Adenocarcinomas and Adenomas

Tumor Biology, 2000
The overexpression of three growth factor receptors: epidermal growth factor receptor (EGFR), ERB B2 and ERB B3 was evaluated immunohistochemically in 77 malignant and 15 benign colorectal neoplasms considering clinicopathological variables (histological structure, grade of differentiation, tumor localization, clinical stage of the disease).
I, Porebska, A, Harlozińska, T, Bojarowski   +2 more
openaire   +3 more sources

Erb-b2 Receptor Tyrosine Kinase 2 Interaction with Growth Factor Receptor Bound Protein 7 Acts as a Molecular Switch to Activate Non-Small Cell Lung Cancer

Biomedical and Biotechnology Research Journal (BBRJ), 2023
Background: The progression and metastasis of non small cell lung cancer (NSCLC) are considered a very complex process as it involves aberrations of multiple genes and cellular pathways. Genes which are differentially expressed in NSCLC have multi interactions with other genes, which can promote the carcinogenesis.
Anita Chauhan, Seema Kalra
openaire   +2 more sources

Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells

Oncology Reports, 2020
The oncogenic role of Erb‑B2 Receptor Tyrosine Kinase 2 (ERBB2) has been identified in several types of cancer, but less is known on its function and mechanism of action in cervical cancer cells. The present study employed a multipronged approach to investigate the role of ERBB2 in cervical cancer.
Liu, Hongli, Li, Yuzhi, Zhang, Jing, Wu, Nan, Liu, Fei, Wang, Lihua, Zhang, Yuan, Liu, Jing, Zhang, Xuan, Guo, Suyang, Wang, Hongtao   +10 more
openaire   +3 more sources

ATG12-dependent autophagy is promoted by the erb-b2 receptor tyrosine kinase 2 (ERBB2), contributing to breast cancer cells' resistance to treatment

International journal of health sciences, 2022
The erb-b2 receptor tyrosine kinase 2 (ERBB2), a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in a variety of malignancies (radio- and chemotherapy)., While the fundamental processes are yet unknown, treatment resistance does. Autophagy is well-known.to increase resistance to cancer therapy.
May Jaleel Abed, Abdalkhaliq A. Abdalameer   +1 more
openaire   +1 more source

The proangiogenic capacity of polymorphonuclear neutrophils delineated by microarray technique and by measurement of neovascularization in wounded skin of CD18-deficient mice [PDF]

, 2006
Growing evidence supports the concept that polymorphonuclear neutrophils (PMN) are critically involved in inflammation-mediated angiogenesis which is important for wound healing and repair.
Addison CL, Armstrong DA, Baggiolini M, Barbara Walzog, Bazzoni F, Benelli R, Bernardini G, Bohnsack JF, Brandes ME, Cacalano G, Choudhuri R, Devalaraja RM, Dewald B, Dubravec DB, Gasperini S, Gaudry M, Grant DS, Grenier A, Grotendorst GR, Harada H, Heiple JM, Ikematsu S, Iruela-Arispe ML, John A, Jürgen Schymeinsky, Karin Scharffetter-Kochanek, Kreis C, Kullander K, Liu XH, Loukinova E, Matzner Y, Muramaki M, Niiro H, Oda N, Pertovaara L, Ramchandran R, Roberts AB, Ruth Schruefer, Sang QX, Sato W, Scapini P, Scharffetter-Kochanek K, Schruefer R, Sehgal I, Semenza GL, Shapiro SD, Silke Sulyok, Takada T, Takada T, Tasiemski A, Thorsten Peters, Triebel S, Walzog B, Wang SC, Willeke T, Yoshida S   +55 more
core   +1 more source

A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines [PDF]

Molecular Pharmacology, 2013
Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole-genome loss-of-function screen to identify genes whose knockdown potentiated the inhibitory effect of the FGFR inhibitor ...
Katherine R, Singleton, Jihye, Kim, Trista K, Hinz, Lindsay A, Marek, Matias, Casás-Selves, Clark, Hatheway, Aik Choon, Tan, James, DeGregori, Lynn E, Heasley   +8 more
openaire   +2 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Catalytic receptors [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +5 more sources

The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]

, 2011
Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P., Traynor, Ryan, Vogt, Janis   +2 more
core   +3 more sources

Platinum resistance in breast and ovarian cancer cell lines [PDF]

, 2011
Breast and ovarian cancers are among the 10 leading cancer types in females with mortalities of 15% and 6%, respectively. Despite tremendous efforts to conquer malignant diseases, the war on cancer declared by Richard Nixon four decades ago seems to be ...
Niels Eckstein
core   +1 more source

Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]

, 2006
The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
Dietrich, Carl Peter, Lopes, Carla Cristina, Nader, Helena Bonciani   +2 more
core   +1 more source