Results 11 to 20 of about 13,813 (161)

Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes [PDF]

Frontiers in Cellular and Infection Microbiology
IntroductionDengue is an arboviral disease causing severe illness in over 500,000 people each year. Currently, there is no way to constrain dengue in the clinic.
Natasha M. Bourgeois, Natasha M. Bourgeois, Ling Wei, Nhi N. T. Ho, Nhi N. T. Ho, Maxwell L. Neal, Denali Seferos, Tinotenda Tongogara, Fred D. Mast, John D. Aitchison, John D. Aitchison, Alexis Kaushansky, Alexis Kaushansky, Alexis Kaushansky   +13 more
doaj   +2 more sources

Progress in clinical diagnosis and treatment of colorectal cancer with rare genetic variants

Cancer Biology & Medicine
Targeted therapy is crucial for advanced colorectal cancer (CRC) positive for genetic drivers. With advances in deep sequencing technology and new targeted drugs, existing standard molecular pathological detection systems and therapeutic strategies can ...
Shuyi Chen, Jing Gu, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu   +4 more
doaj   +2 more sources

Transcriptional Reinforcement of the HER2-RAS Network in HER2-Positive Gastric Cancer: The RUNX-SOS1 Axis in Context. [PDF]

Cancer Sci
RUNX‐dependent transcriptional control of SOS1 reinforces HER2–RAS signaling and may attenuate responses to HER2‐targeted therapies in HER2‐positive gastric cancer. ABSTRACT HER2‐positive gastric cancer represents a distinct molecular subtype characterized by chromosomal instability, variable HER2 amplification, and substantial intratumoral ...
Masuda T, Watanabe T, Ozaki T, Kamikubo Y.   +3 more
europepmc   +2 more sources

Non-HLA Risk Loci ERBB3/IKZF4 and ERBB2/IKZF3/GSDMB/ORMDL3 Interact to Influence Progression of Autoimmunity in Relatives of T1D Patients. [PDF]

Diabetes Metab Res Rev
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Mertens IM, Keymeulen B, Gorus FK, Van De Casteele M, Belgian Diabetes Registry.   +4 more
europepmc   +2 more sources

ATG12-dependent autophagy is promoted by the erb-b2 receptor tyrosine kinase 2 (ERBB2), contributing to breast cancer cells' resistance to treatment

International journal of health sciences, 2022
The erb-b2 receptor tyrosine kinase 2 (ERBB2), a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in a variety of malignancies (radio- and chemotherapy)., While the fundamental processes are yet unknown, treatment resistance does. Autophagy is well-known.to increase resistance to cancer therapy.
May Jaleel Abed, Abdalkhaliq A. Abdalameer   +1 more
openaire   +1 more source

ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]

, 2004
Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core   +1 more source

Syk-mediated translocation of PI3Kδ to the leading edge controls lamellipodium formation and migration of leukocytes [PDF]

, 2007
The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β2 integrin-mediated leukocyte activation.
Jakus, Zoltán, Walzog, Barbara, Cornelia Then, Scharffetter-Kochanek, Karin, Then, Cornelia, Victor L. J. Tybulewicz, Barbara Walzog, Ronald Gerstl, Zoltán Jakus, Sindrilaru, Anca, Jürgen Schymeinsky, Schymeinsky, Juergen, Anca Sindrilaru, Gerstl, Ronald, Tybulewicz, Victor L. J., Victor L J Tybulewicz, Karin Scharffetter-Kochanek, Schymeinsky, Jürgen, Tybulewicz, Victor LJ   +18 more
core   +1 more source

A Receptor Tyrosine Kinase Network Composed of Fibroblast Growth Factor Receptors, Epidermal Growth Factor Receptor, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, and Hepatocyte Growth Factor Receptor Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines [PDF]

Molecular Pharmacology, 2013
Our laboratory has previously shown that some gefitinib-insensitive head and neck squamous cell carcinoma (HNSCC) cell lines exhibit dominant autocrine fibroblast growth factor receptor (FGFR) signaling. Herein, we deployed a whole-genome loss-of-function screen to identify genes whose knockdown potentiated the inhibitory effect of the FGFR inhibitor ...
Katherine R, Singleton, Jihye, Kim, Trista K, Hinz, Lindsay A, Marek, Matias, Casás-Selves, Clark, Hatheway, Aik Choon, Tan, James, DeGregori, Lynn E, Heasley   +8 more
openaire   +2 more sources

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

ERBB2-modulated ATG4B and autophagic cell death in human ARPE19 during oxidative stress.

PLoS ONE, 2019
Age-related macular degeneration (AMD) is an ocular disease with retinal degeneration. Retinal pigment epithelium (RPE) degeneration is mainly caused by long-term oxidative stress. Kinase activity could be either protective or detrimental to cells during
Shwu-Jiuan Sheu, Jiunn-Liang Chen, Youn-Shen Bee, Shi-Han Lin, Chih-Wen Shu   +4 more
doaj   +1 more source