Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
PLoS ONE, 2013 BackgroundThere is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Inka Regine Weingaertner +2 more
doaj +10 more sources
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling [PDF]
EMBO Journal, 1997 We have analyzed ErbB receptor interplay induced by the epidermal growth factor (EGF)-related peptides in cell lines naturally expressing the four ErbB receptors. Down-regulation of cell surface ErbB-1 or ErbB-2 by intracellular expression of specific antibodies has allowed us to delineate the role of these receptors during signaling elicited by: EGF ...
Graus-Porta D +3 more
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The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin [PDF]
Oncogene, 1998 The ErbB-1 receptor tyrosine kinase binds to six different growth factors, whose prototype is the epidermal growth factor (EGF). Two homologous epithelial receptors, ErbB-3 and ErbB-4, bind all isoforms of another family of growth factors, the Neu differentiation factors (NDFs/neuregulins).
Ronit Pinkas-Kramarski
exaly +4 more sources
The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
Epigenomes, 2023 Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC ...
Georgios Androutsopoulos +6 more
doaj +1 more source
A comparative study of the clinical characteristics and outcomes of HR-positive HER2-negative breast cancer patients over and under 65 years old [PDF]
Korean Journal of Clinical Oncology, 2021 Purpose The purpose of this study was to compare the clinical characteristics and outcomes of hormone receptor-positive (HR+) human epidermal growth factor 2-negative (HER2−) breast cancer among elderly patients (over 65 years old) and younger patients ...
Chang Shin Jung +6 more
doaj +1 more source
Cell Death and Disease, 2022 Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera +18 more
doaj +1 more source
ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors [PDF]
Journal of Biological Chemistry, 1999 ErbB-2/HER2 is an important signaling partner for the epidermal growth factor receptor (EGFR). Overexpression of erbB-2 is also associated with poor prognosis in breast cancer. To investigate how erbB-2 amplification affects its interactions with the EGFR, we used a human mammary epithelial cell system in which erbB-2 expression was increased 7-20-fold
R, Worthylake, L K, Opresko, H S, Wiley
openaire +2 more sources
Endosomal Transport of ErbB-2: Mechanism for Nuclear Entry of the Cell Surface Receptor [PDF]
Molecular and Cellular Biology, 2005 The cell membrane receptor ErbB-2 migrates to the nucleus. However, the mechanism of its nuclear translocation is unclear. Here, we report a novel mechanism of its nuclear localization that involves interaction with the transport receptor importin beta1, nuclear pore protein Nup358, and a host of players in endocytic internalization.
Dipak K, Giri +7 more
openaire +2 more sources
Identification of the zinc finger 216 (ZNF216) in human carcinoma cells. A potential regulator of EGFR activity [PDF]
, 2016 Epidermal Growth Factor Receptor (EGFR), a member of the ErbB family of receptor tyrosine kinase (RTK) proteins, is aberrantly expressed or deregulated in tumors and plays pivotal roles in cancer onset and metastatic progression.
Calogero, Antonella +10 more
core +8 more sources
The Catalytic Activity of the ErbB-2 Receptor Tyrosine Kinase Is Essential for Embryonic Development [PDF]
Molecular and Cellular Biology, 2002 Activation of the epidermal growth factor receptor (EGFR) family is thought to play a critical role in both embryogenesis and oncogenesis. The diverse biological activities of the EGFR family are achieved through various ligand-receptor and receptor-receptor interactions. One receptor that has been found to play a central role in this signaling network
Richard, Chan +4 more
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