Results 171 to 180 of about 28,139,738 (307)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Formation of charge-polarized regions at dual single-atom sites for C-H bond activation in methane. [PDF]

Nat Commun
Chen D, Zhou J, Lyu W, Zhao X, Fang R, Wang F, Li Y.   +6 more
europepmc   +1 more source

Stability and C-H Bond Activation Reactions of Palladium(I) and Platinum(I) Metalloradicals: Carbon-to-Metal H-Atom Transfer and an Organometallic Radical Rebound Mechanism. [PDF]

J Am Chem Soc, 2023
Krämer T, Gyton MR, Bustos I, Sinclair MJG, Tan SY, Wedge CJ, Macgregor SA, Chaplin AB.   +7 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Basicity-Controlled C-H Bond Activation by a Structurally Characterized Ni(III)-Hydroxo Complex. [PDF]

J Am Chem Soc
Pan HR, Wu J, Tsai CM, Liao PJ, Hsu HF.
europepmc   +1 more source

Adsorption of Polycyclic Aromatic Hydrocarbons and C₆₀ onto Forsterite: C-H Bond Activation by the Schottky Vacancy. [PDF]

ACS Earth Space Chem, 2022
Campisi D, Lamberts T, Dzade NY, Martinazzo R, Ten Kate IL, Tielens AGGM.   +5 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Advances in transition-metal catalyzed C-H bond activation of amidines to synthesize aza-heterocycles. [PDF]

RSC Adv
Ren J, Xiong Y, Li Q, Wang B, Wang G, Wang B, Liu H, Yang X.   +7 more
europepmc   +1 more source

Direct Nucleophilic Attack/Addition Cyclization and C-H Bond Activation Reactions to Synthesize 3-Benzyl-/3-Benzyl-2-phenyl-benzo[4,5]imidazo[2,1-b]thiazoles. [PDF]

ACS Omega, 2023
Wang D, Zhao L, Zhang Y, Zhang Y, Huang X, Shen G.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source