Results 191 to 200 of about 834,266 (345)

O₂ Activation and Enzymatic C-H Bond Activation Mediated by a Dimanganese Cofactor. [PDF]

J Am Chem Soc
Liu C, Rao G, Nguyen J, Britt RD, Rittle J.   +4 more
europepmc   +1 more source

C-H Bond Activation Mechanism by a Pd(II)-(μ-O)-Au(0) Structure Unique to Heterogeneous Catalysts. [PDF]

JACS Au, 2022
Takei D, Yatabe T, Yabe T, Miyazaki R, Hasegawa JY, Yamaguchi K.   +5 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Remote C─H Bond Activation via Enantioselective Carbopalladation and 1,4-Pd Migration Cascade Process. [PDF]

Adv Sci (Weinh)
Xu B, Ji D, Zhang ZM, Zhang J.
europepmc   +1 more source

Ru(II)-Catalyzed Hydroarylation of in situ Generated 3,3,3-Trifluoro-1-propyne by C-H Bond Activation: A Facile and Practical Access to β-Trifluoromethylstyrenes. [PDF]

Chemistry, 2022
Vuagnat M, Tognetti V, Jubault P, Besset T.   +3 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Palladium/norbornene-catalyzed C-H bond activation and annulation to construct polycyclic aromatic hydrocarbon-based fluorescent materials. [PDF]

Chem Sci
Zhou C, Yang X, Gou L, Li B.
europepmc   +1 more source

Direct Cyclopalladation of Fluorinated Benzyl Amines by Pd₃(OAc)₆: The Coexistence of Multinuclear Pd_n Reaction Pathways Highlights the Importance of Pd Speciation in C-H Bond Activation. [PDF]

Organometallics, 2023
Fairlamb IJS, Lang J, Růžička A, Sedlák M, Váňa J.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Unexpected Formation of Neutral Alkyl-Ni(II) Complexes Bearing Unsymmetrical <i>C</i>,<i>N</i>,<i>N</i>'-Pincer Iminopyrrolyl Ligands via Intramolecular C-H Bond Activation: A Distinct Type of Single-Component Ethylene Polymerization Catalysts. [PDF]

Inorg Chem
Figueira CA, Lopes PS, Meyrelles R, Gomes CSB, Gomes JCS, Veiros LF, Gomes PT.   +6 more
europepmc   +1 more source