Results 41 to 50 of about 23,038 (267)

Recent Advancement in Palladium Catalysed C-C bond Activation of Strained Ring Systems: Three and four-membered carbocycles as prominent C3/C4 building blocks

, 2022
In recent years, transition metal catalysed strong C-C bond activation has significantly attracted the attention of synthetic chemists. This enables simultaneous and direct functionalization of two different M-C bonds.
Tanmayee, Nanda, Astha, Linda, Ponneri C., Ravikumar, Bedadyuti Vedvyas , Pati, Shyam Kumar, Banjare, Pragati , Biswal, Muhammed, Fastheem   +6 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

C–H Activation via Group 8–10 Pincer Complexes: A Mechanistic Approach

Inorganics
C–H bond activation is a crucial synthetic strategy widely utilized in both academic and industrial settings. Due to the strong and kinetically inert nature of the C–H bond, its functionalization typically requires metal-based catalysts.
Juan S. Serrano-García, Andrés Amaya-Flórez, Jordi R.-Galindo, Lucero González-Sebastián, Luis Humberto Delgado-Rangel, David Morales-Morales   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

C-H bond Activation/Arylation over Arene-Ruthenium(II)-picolinate Complexes: Synthesis, Structure and Catalytic Activity

, 2017
A series of water soluble arene-ruthenium(II) complexes [(η6-arene)RuCl(κ2-L)]n+ (n = 0, 1) ([Ru]-1 – [Ru]-12) containing pyridine based N,O or N,N ligands (L1-L6) were synthesized and employed for the catalytic C-H bond activation/ arylation of 2 ...
Chinky, Binnani, Rohit K., Rai, Sanjay Kumar, Singh, Deepika, Tyagi, Shaikh M, Mobin   +4 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

New approaches to organocatalysis based on C–H and C–X bonding for electrophilic substrate activation

Beilstein Journal of Organic Chemistry, 2016
Hydrogen bond donor catalysis represents a rapidly growing subfield of organocatalysis. While traditional hydrogen bond donors containing N–H and O–H moieties have been effectively used for electrophile activation, activation based on other types of non ...
Pavel Nagorny, Zhankui Sun
doaj   +1 more source

The Activating Effect of Strong Acid for Pd-Catalyzed Directed C–H Activation by Concerted Metalation-Deprotonation Mechanism

Molecules, 2021
A computational study on the origin of the activating effect for Pd-catalyzed directed C–H activation by the concerted metalation-deprotonation (CMD) mechanism is conducted.
Heming Jiang, Tian-Yu Sun
doaj   +1 more source

Heterolytic bond activation at gold: Evidence for gold(III) H-B, H-Si complexes, H-H and H-C cleavage [PDF]

, 2019
The coordinatively unsaturated gold(III) chelate complex [(C^N-CH)Au(C6F5)]+ (1+) reacts with main group hydrides H-BPin and H-SiEt3 in dichloromethane solution at 70 °C to form the corresponding σ-complexes, which were spectroscopically characterized (C^
Budzelaar, Peter, Bochmann, Manfred, Bochmann M., Rocchigiani L., Budzelaar P. H. M., Rocchigiani, Luca   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source