Results 101 to 110 of about 81,067 (257)

Identification and characterization of long-range SOX9 enhancers in limb development [PDF]

, 2013
The transcription factor Sox9 is a master regulator of skeletogenesis. Heterozygous mutations of human SOX9 result in Campomelic Dysplasia (CD), in which affected individuals display distinct abnormalities in limbs and other skeletal assemblies. Recently,
Chan, D, Cheah, KSE, Cheung, M, Hui, CC, Wu, MH, Yip, RKH   +5 more
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Early growth response genes 2 and 3 regulate the expression of Bcl6 and differentiation of T follicular helper cells [PDF]

, 2015
T follicular helper (Tfh) cells support differentiation of B cells to plasma cells and high affinity antibody production in germinal centers (GC) and Tfh differentiation requires the function of B cell lymphoma 6 (Bcl6). We have now discovered that early
Alistair L.J. Symonds, Allen, Ane Ogbe, Bauquet, Becky Omodho, Bollig, Carvalho, Choi, Chtanova, Crotty, Crotty, Dent, Hao, Harris, Hothorn, Huang, Ise, Johnston, Johnston, Kwon, Li, Liu, Liu, Ma, Nakayamada, Nurieva, Nurieva, Ovcharenko, Ping Wang, Punamdip Bhullar, Qi, R Core Team, Randeep Singh, Safford, Shaffer, Sofra, Suling Li, Tizong Miao, Vinuesa, Wickham, Ye, Yu, Zhu   +42 more
core   +1 more source

Natural Negative Feedback Loops Confer Indica‐Japonica Differentiation for Grain Size Homeostasis in Rice

Advanced Science, EarlyView.
This study reveals the genetic and molecular mechanisms controlling grain size homeostasis through fine‐tuning OsGRX8 self‐expression by two natural negative feedback loops functioning in redox‐dependent or ‐independent manners and identifies two self‐regulatory haplotypes (SRHs) for the subspecies differentiation in rice.
Xingxing Li, Meng‐en Wu, Ziqi Qiao, Junkui Huang, Juncheng Zhang, Yang Ding, Junqing Zhu, Jingyue Xu, Yuxin Huang, Wei Li, Xiaomin Su, Yue Ding, Jianwei Zhang, Yibo Li   +13 more
wiley   +1 more source

Kinesin-1 is involved in chondrocytes adhesion to extracellular matrix and motility [PDF]

, 2013
Intercalation movement of proliferative chondrocytes is crucial for their columnar organization which is essential for proper function of growth plate cartilage.
Chan, D, Cheah, K, Gan, H, Huang, J, Xue, MW, Zhu, GX   +5 more
core  

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

Advanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao, Hanpeng Luo, Dailu Guan, Xuefeng Fu, Feng Wang, Guoming Zhang, Shanglai Li, Hua Yang, Yanli Zhang   +8 more
wiley   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source

MMP14 regulates the lineage progression of hypertrophic chondrocytes [PDF]

, 2013
It is traditionally believed that chondrocytes and osteoblasts are two separate lineages with hypertrophic chondrocytes (HCs) being the terminal stage of chondrocyte differentiation, culminating in apoptosis.
Cheah, KSE, Chu, TL, Tsang, KY, Tsang, SW, Zhou, Z   +4 more
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The regulation of IL-10 expression [PDF]

, 2014
Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding of how IL-10 expression is controlled is critical in the design of immune intervention strategies.
A Banerjee, A Blokzijl, A Boonstra, A Chakrabarti, A Chaudhry, A Gaba, A Kimura, A Kitani, A Neininger, A Sharma, A Villagra, AD Edwards, AD Edwards, AD Foey, AG Jarnicki, AK Yi, AM Smith, AN Ahyi, B Corre, B Csoka, B Lenhard, B Li, B Schaljo, C Dong, C Jiang, C Kemper, C Platzer, C Pot, C Pot, C Tudor, CD Dumitru, CF Fuqua, CG Lee, CG Lee, CY Brown, D Jarrossay, D Nandan, D Yu, DC Fitzgerald, DM Reid, E Carballo, E Carballo, E Cretney, E Hitti, E Kanters, EA Jones, EC Slack, EM Benkhart, EY Chang, EY Chung, F Dodeller, F Kaiser, F Kratochvill, F Ma, F Macian, F Radtke, FJ Sheedy, FW McNab, G Brewer, G Chen, G Friec Le, G Guarda, G Kassiotis, G Stoecklin, G Stoecklin, G Strassmann, G Vahedi, G Vahedi, GA Martins, GD Kalliolias, GI Forte, H Chi, H Hacker, H Sandler, H Wang, H Yu, HC Chang, HD Brightbill, HD Chang, HJ Lee, IC Ho, II Ivanov, J Das, J Rengarajan, J Shoemaker, J Sun, J Xu, J Zhu, J Zhu, JA Zhang, JI Kim, JM Kim, JS Gerber, JS Stumhofer, K Clark, KA Mowen, KD Mayer-Barber, KF MacKenzie, KJ Staples, KM Dennehy, KM Murphy, KW Moore, L Apetoh, L Kim, L Wei, L Ziegler-Heitbrock, LA O’Neill, M Batten, M Brook, M Bros, M Ciofani, M Hammer, M Karin, M Lucas, M Martin, M Martin, M Ohtani, M Saraiva, M Saraiva, M Saraiva, M Tone, M Veldhoen, MJ Aman, MJ Pattison, MJ Powell, MK Levings, N Kadowaki, N Kedersha, N Mori, NC Rogers, O Ananieva, P Anderson, P Ivanov, P Li, PC Hollenhorst, PE Fields, PJ Murray, Q Yu, R Grenningloh, R Lang, R Spolski, R Tussiwand, RI Nurieva, RJ Brownlie, RJ Johnston, S Agrawal, S Brenner, S Cao, S Cao, S Dillon, S Dillon, S Gerondakis, S Kusam, S Rutz, SH Im, SJ Szabo, SS Iyer, T Gantke, T Ito, T Jenuwein, T Kawai, T Krausgruber, T Owaki, T Weichhart, TL Murphy, TM Franks, V Romano-Spica, VR Ramirez-Carrozzi, W Ma, W Zheng, WT Watford, X Hu, X Liu, X Pichon, X Zhang, Y Alvarez, Y Motomura, YW Liu, ZH Nemeth, ZY Wang   +179 more
core   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Methionine adenosyltransferases in liver cancer. [PDF]

, 2019
Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions within the cell.
Barbier-Torres, Lucia, Fan, Wei, Lu, Shelly C, Mato, José M, Murray, Ben   +4 more
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