Results 141 to 150 of about 82,350 (159)

c-Maf Expression in Angioimmunoblastic T-cell Lymphoma

American Journal of Surgical Pathology, 2007
The oncogene c-Maf was recently found to be overexpressed in approximately 50% of multiple myeloma cases, and a role for c-Maf in promoting cyclin D2 expression has been postulated. We previously examined c-Maf expression in various T-cell lymphomas by reverse-transcription polymerase chain reaction and found extremely elevated c-Maf levels in ...
Yoshiko Idate, Murakami, Yasushi, Yatabe, Teruhiro, Sakaguchi, Eiichi, Sasaki, Yoriko, Yamashita, Naoki, Morito, Keigyou, Yoh, Yuuki, Fujioka, Fumihiko, Matsuno, Hiroyuki, Hata, Hiroaki, Mitsuya, Shigehiko, Imagawa, Atsushi, Suzuki, Hiroyasu, Esumi, Masaharu, Sakai, Satoru, Takahashi, Naoyoshi, Mori   +16 more
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Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver

Biochemical and Biophysical Research Communications, 2004
Maf is a family of oncogenes which encodes a nuclear bZip transcription factor protein and has been originally identified from the avian oncogenic retrovirus, AS42. Maf genes have been reported to have critical roles in embryological development and cellular differentiation.
Junko, Imaki, Ken, Tsuchiya, Takuya, Mishima, Hidetaka, Onodera, James I, Kim, Kazuhiko, Yoshida, Hiromi, Ikeda, Masaharu, Sakai   +7 more
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A Chemical Biology Screen Identifies Glucocorticoids as Inhibitors of C-Maf and C-Maf-Dependent Transactivation of Cyclin D2.

Blood, 2006
Abstract The oncogene c-maf is frequently over-expressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. Therefore, small molecules that inhibit c-maf and its targets could be useful chemical probes to better understand the role and ...
MAO X., STEWART A. K., HURREN R., DATTI, Alessandro, SHI C. X., ZHU Y. X., LEE K., TIEDEMANN R., EBERHARD Y., COREY S. J., WRANA J., SCHIMMER A. D.   +11 more
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c-Maf rules the island

Blood, 2011
In this issue of Blood , Kusakabe et al make a compelling case that the transcription factor c-Maf is critical for erythroblastic island formation and fetal erythropoiesis. 1 The cell adhesion molecule VCAM-1 is a potential mediator of c-Maf activity.
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Variable Effects of Transgenic c-Maf on Autoimmune Diabetes

Diabetes, 2001
Autoimmune diabetes is associated with T helper 1 polarization, but protection from disease can be provided by the application of T helper 2 (Th2) cytokines. To test whether genetic manipulation of T-cells can provide protective Th2 responses, we developed transgenic mice in which T-cells express the interleukin-4-specific transcription factor c-Maf ...
M E, Pauza, A, Nguyen, T, Wolfe, I C, Ho, L H, Glimcher, M, von Herrath, D, Lo   +6 more
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USF2/FIP Associates with the b-Zip Transcription Factor, c-Maf, via Its bHLH Domain and Inhibits c-Maf DNA Binding Activity

Biochemical and Biophysical Research Communications, 1997
In screening for proteins that interact with the basic zipper (bZip) transcription factor, c-Maf, we isolated USF2/FIP. USF2 is a member of the bHLH-Zip protein family, possessing a basic (b) DNA binding region, a helix-loop-helix (HLH) motif, and a leucine zipper (Zip) structure.
C, Kurschner, J I, Morgan
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c-Maf in CD4+ T cells: it’s all about context

Nature Immunology, 2018
The role of the transcription factor c-Maf varies in different CD4+ T cell subsets and can be associated with either pro-inflammatory activity or anti-inflammatory activity, depending on the cell context.
W. Nicholas Haining, Sarah A. Weiss
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Molecular insights into dimerization inhibition of c-Maf transcription factor

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2014
The Maf protein family belongs to the activator protein 1 (AP-1) superfamily of transcription factors that bind specific DNA target sequences through a basic region and exploit a leucine zipper (LZ) motif for protein-protein interactions leading to homo- or hetero-dimerization.
S. Pellegrino, L. Ronda, ANNONI, CHIARA, A. Contini, E. Erba, M.L. Gelmi, R. Piano, G. Paredi, A. Mozzarelli, S. Bettati   +9 more
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Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Blood, 2021
Abstract The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), but how to achieve it is still elusive. In the present study, we found the Otub1/c-Maf axis could be a potential target.
Yujia Xu, Min Xu, Jiefei Tong, Xiaowen Tang, Jinhao Chen, Xuehan Chen, Zubin Zhang, Biyin Cao, A. Keith Stewart, Michael F. Moran, Depei Wu, Xinliang Mao   +11 more
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C-MAF Oncogene Dysregulation in Multiple Myeloma: Frequency and Biological Relevance

Leukemia & Lymphoma, 2003
To investigate the frequency and possible biological consequences of c-maf dysregulation, we designed c-maf and IL-4 real-time RT-PCR assays for determination of c-maf and IL-4 mRNA levels. Using the c-maf real-time RT-PCR assay, we tested a panel of 14 B-cell lines, 135 diagnostic bone marrow (BM) samples from patients with multiple myeloma and 10 BM ...
Thomas, Rasmussen, Lene Meldgaard, Knudsen, Inger Marie S, Dahl, Hans Erik, Johnsen   +3 more
openaire   +2 more sources