Results 241 to 250 of about 81,067 (257)

A Chemical Biology Screen Identifies Glucocorticoids as Inhibitors of C-Maf and C-Maf-Dependent Transactivation of Cyclin D2.

Blood, 2006
Abstract The oncogene c-maf is frequently over-expressed in multiple myeloma cell lines and patient samples and contributes to increased cellular proliferation in part by inducing cyclin D2 expression. Therefore, small molecules that inhibit c-maf and its targets could be useful chemical probes to better understand the role and ...
MAO X., STEWART A. K., HURREN R., DATTI, Alessandro, SHI C. X., ZHU Y. X., LEE K., TIEDEMANN R., EBERHARD Y., COREY S. J., WRANA J., SCHIMMER A. D.   +11 more
openaire   +2 more sources

c-Maf rules the island

Blood, 2011
In this issue of Blood , Kusakabe et al make a compelling case that the transcription factor c-Maf is critical for erythroblastic island formation and fetal erythropoiesis. 1 The cell adhesion molecule VCAM-1 is a potential mediator of c-Maf activity.
openaire   +2 more sources

Variable Effects of Transgenic c-Maf on Autoimmune Diabetes

Diabetes, 2001
Autoimmune diabetes is associated with T helper 1 polarization, but protection from disease can be provided by the application of T helper 2 (Th2) cytokines. To test whether genetic manipulation of T-cells can provide protective Th2 responses, we developed transgenic mice in which T-cells express the interleukin-4-specific transcription factor c-Maf ...
M E, Pauza, A, Nguyen, T, Wolfe, I C, Ho, L H, Glimcher, M, von Herrath, D, Lo   +6 more
openaire   +2 more sources

USF2/FIP Associates with the b-Zip Transcription Factor, c-Maf, via Its bHLH Domain and Inhibits c-Maf DNA Binding Activity

Biochemical and Biophysical Research Communications, 1997
In screening for proteins that interact with the basic zipper (bZip) transcription factor, c-Maf, we isolated USF2/FIP. USF2 is a member of the bHLH-Zip protein family, possessing a basic (b) DNA binding region, a helix-loop-helix (HLH) motif, and a leucine zipper (Zip) structure.
C, Kurschner, J I, Morgan
openaire   +2 more sources

c-Maf in CD4+ T cells: it’s all about context

Nature Immunology, 2018
The role of the transcription factor c-Maf varies in different CD4+ T cell subsets and can be associated with either pro-inflammatory activity or anti-inflammatory activity, depending on the cell context.
W. Nicholas Haining, Sarah A. Weiss
openaire   +2 more sources

Molecular insights into dimerization inhibition of c-Maf transcription factor

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2014
The Maf protein family belongs to the activator protein 1 (AP-1) superfamily of transcription factors that bind specific DNA target sequences through a basic region and exploit a leucine zipper (LZ) motif for protein-protein interactions leading to homo- or hetero-dimerization.
S. Pellegrino, L. Ronda, ANNONI, CHIARA, A. Contini, E. Erba, M.L. Gelmi, R. Piano, G. Paredi, A. Mozzarelli, S. Bettati   +9 more
openaire   +4 more sources

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Blood, 2021
Abstract The oncogenic transcription factor c-Maf has been proposed as an ideal therapeutic target for multiple myeloma (MM), but how to achieve it is still elusive. In the present study, we found the Otub1/c-Maf axis could be a potential target.
Yujia Xu, Min Xu, Jiefei Tong, Xiaowen Tang, Jinhao Chen, Xuehan Chen, Zubin Zhang, Biyin Cao, A. Keith Stewart, Michael F. Moran, Depei Wu, Xinliang Mao   +11 more
openaire   +2 more sources

C-MAF Oncogene Dysregulation in Multiple Myeloma: Frequency and Biological Relevance

Leukemia & Lymphoma, 2003
To investigate the frequency and possible biological consequences of c-maf dysregulation, we designed c-maf and IL-4 real-time RT-PCR assays for determination of c-maf and IL-4 mRNA levels. Using the c-maf real-time RT-PCR assay, we tested a panel of 14 B-cell lines, 135 diagnostic bone marrow (BM) samples from patients with multiple myeloma and 10 BM ...
Thomas, Rasmussen, Lene Meldgaard, Knudsen, Inger Marie S, Dahl, Hans Erik, Johnsen   +3 more
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c-Maf Induces Monocytic Differentiation and Apoptosis in Bipotent Myeloid Progenitors

Blood, 1999
The transcriptional mechanisms that drive colony-forming unit granulocyte-macrophage (CFU-GM) myeloid progenitors to differentiate into cells of either the granulocytic or monocytic lineage are not fully understood. We have shown that the c-Maf and c-Myb transcription factors physically interact in myeloid cells to form inhibitory complexes that hinder
S P, Hegde, J, Zhao, R A, Ashmun, L H, Shapiro   +3 more
openaire   +2 more sources

Regulation of GM-CSF expression by the transcription factor c-Maf

Journal of Allergy and Clinical Immunology, 2007
Inflammation is a key feature of asthma and allergic disease. The proinflammatory cytokines IL-4, IL-5, and IL-13 are clustered on chromosome 5q with GM-CSF in close proximity, and each of these cytokines has been implicated in the pathogenesis of inflammatory disease.
Gilmour, Jane, Cousins, David J, Richards, David F, Sattar, Zahid, Lee, Tak H, Lavender, Paul   +5 more
openaire   +3 more sources