PL02.1.A DELINEATING AND TARGETING A NOVEL METABOLISM-BASED POST-TRANSLATIONAL MECHANISM REGULATING THE ABUNDANCE OF THE ‘UNDRUGGABLE’ ONCOPROTEIN C-MYC IN MEDULLOBLASTOMA [PDF]
, 2023 Emma Martell +13 more
openalex +1 more source
P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation [PDF]
, 2014 Glioblastoma (GBM) is a highly lethal brain tumor presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM subtype presents acutely as high-grade disease that typically harbors EGFR, Pten and Ink4a/Arf ...
Brennan, Cameron +19 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
Nature Communications, 2016 c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are unknown.
Laia Richart +6 more
semanticscholar +1 more source
Investigation of c-Myc gene amplification in breast cancer patients and its correlation with other prognostic factors [PDF]
, 2018 Background: Breast cancer is the most common cancer in woman. The frequency of amplification of some proto-oncogenes like c-Myc gene may be various in different populations.
Akbari, Mohammad Esmaeel +2 more
core
Ribosome biogenesis during skeletal muscle hypertrophy [PDF]
, 2014 Muscle adaptation to chronic resistance exercise (RE) is the result of a cumulative effect on gene expression and protein content. Following a bout of RE, muscle protein synthesis increases and, if followed by consecutive bouts (training), protein ...
Walden, Ferdinand von
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Anti-c-myc efficacy block EGFL7 induced prolactinoma tumorigenesis
Open Chemistry, 2019 Resistance to Dopamine agonists therapy is still a key factor that hinders the clinical treatment of prolactinoma. Consequently, a large number of investigations have been carried out to identify novel therapeutic targets.
Lan Xiaolei +4 more
doaj +1 more source
c-Myc activates
BMC Cancer, 2011 Background The BRCA1 gene plays an important role in the maintenance of genomic stability. BRCA1 inactivation contributes to breast cancer tumorigenesis. An increasing number of transcription factors have been shown to regulate BRCA1 expression.
Huo Dezheng +5 more
doaj +1 more source