Results 141 to 150 of about 19,205,329 (382)
ヒト乳癌における熱ショック蛋白質70とc-myc蛋白質の発現に関する研究 [PDF]
, 1991 The major heat shock protein, HSP70, protects cells from a variety of stressful stimuli, while c-myc protein allegedly stimulates expression of HSP70 by transacting on the HSP70 promotor.This study was aimed at correlating expression of HSP70 with that ...
田内 克典
core +1 more source
A new mutation-independent approach to cancer therapy : inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis. [PDF]
, 2017 Here, we used MCF7 cells as a model system to interrogate how MYC/RAS co-operativity contributes to metabolic flux and stemness in breast cancer cells.
Blagosklonny +25 more
core +1 more source
Macrophages and c-Myc cross paths [PDF]
OncoImmunology, 2016 The c-Myc transcription factor has recently been proposed as a bona fide M2 macrophage marker. Although this finding represents a major step forward in the identification of different macrophage subsets, it also opens up the potential for speculation concerning the possible functions of c-Myc in macrophages and the implications for health and disease.
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Differentiation-Inducing Factor-1 Suppresses the Expression of c-Myc in the Human Cancer Cell Lines
Journal of Pharmacological Sciences, 2013 Differentiation-inducing factor-1 (DIF-1), a morphogen for Dictyostelium discoideum, inhibits the proliferation of human cancer cell lines by suppressing the Wnt/β-catenin signaling pathway.
Kentaro Jingushi +7 more
doaj +1 more source
Potensi Kemopreventif Ekstrak Etanolik Kulit Jeruk Keprok (Citrus Reticulata) Pada Karsinogenesis Sel Hepar Tikus Galur Sprague Dawley Terinduksi Dmba [PDF]
, 2011 Salah satu titik tangkap strategi penemuan agen kemopreventif kanker khususnya kanker hepar adalah melalui penghambatan proliferasi dan penekanan ekspresi onkogen c-Myc. Tangeretin, nobiletin, dan hesperidin adalah beberapa senyawa aktif dari kulit jeruk
Meiyanto, E. (Edy)
core
PLoS ONE, 2013 Over-expression of the proto-oncogene c-MYC is frequently observed in a variety of tumors and is a hallmark of Burkitt´s lymphoma. The fact that many tumors are oncogene-addicted to c-MYC, renders c-MYC a powerful target for anti-tumor therapy. Using a xenogenic vaccination strategy by immunizing C57BL/6 mice with human c-MYC protein or non-homologous ...
Helm, Florian +7 more
openaire +5 more sources
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Zap70 Functions to Maintain Stemness of Mouse Embryonic Stem Cells by Negatively Regulating Jak1/Stat3/c-Myc Signaling [PDF]
, 2010 Young Cha +9 more
openalex +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source