Results 221 to 230 of about 19,205,329 (382)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

miRNA-320a inhibits tumor proliferation and invasion by targeting c-Myc in human hepatocellular carcinoma

, 2017
Fei Xie, Yuncang Yuan, Luyang Xie, Pengzhan Ran, Xudong Xiang, Qionglin Huang, Guoxiang Qi, Xiaopeng Guo, Chunjie Xiao, Shangyong Zheng   +9 more
openalex   +2 more sources

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Cell, 2012
Charles Y. Lin, Jakob Lovén, P. Rahl, Ronald M. Paranal, C. Burge, J. Bradner, Tong Ihn Lee, R. Young   +7 more
semanticscholar   +1 more source

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability. [PDF]

J Transl Med
He C, Tang C, Guo J, Yin X, Zhu Q, Fang C.   +5 more
europepmc   +1 more source

Targeted Deletion of Multiple CTCF-Binding Elements in the Human C-MYC Gene Reveals a Requirement for CTCF in C-MYC Expression

, 2009
Wendy M. Gombert, Anton Krumm
openalex   +2 more sources

A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation

Cell Death and Differentiation, 2017
Qi Yang, W. Du, Nan Wu, Weining Yang, F. Awan, L. Fang, Jian Ma, Xiangmin Li, Yan Zeng, Zhenguo Yang, Jun Dong, Azam Khorshidi, Burton B. Yang   +12 more
semanticscholar   +1 more source

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

Gastric intestinal metaplasia subtypes and the effects of c-Myc expression on severity. [PDF]

PeerJ
Yang Q, Lian L, Shen J, Cao Q, Wang X, Hu P.   +5 more
europepmc   +1 more source

c-Myc-Induced Long Non-Coding RNA Small Nucleolar RNA Host Gene 7 Regulates Glycolysis in Breast Cancer [PDF]

, 2019
Linlei Zhang, Yanying Fu, Hao Guo
openalex   +1 more source