Results 351 to 360 of about 19,205,329 (382)

Tumor Necrosis Factor Receptor–Associated Factor 6 Promotes Hepatocarcinogenesis by Interacting With Histone Deacetylase 3 to Enhance c‐Myc Gene Expression and Protein Stability

Hepatology, 2020
The oncogene c‐Myc is aberrantly expressed and plays a key role in malignant transformation and progression of hepatocellular carcinoma (HCC). Here, we report that c‐Myc is significantly up‐regulated by tumor necrosis factor receptor–associated factor 6 (
Hua‐Lang Wu, Tian-Yu Yang, Yi Li, Wen-Long Ye, Feng Liu, Xiao-Shun He, Jing-Ru Wang, W. Gan, Xiu-Ming Li, Shen Zhang, Yuan-Yuan Zhao, Jianming Li   +11 more
semanticscholar   +1 more source

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

The International Journal of Biochemistry & Cell Biology, 2011
The c-Myc oncoprotein plays critical roles in multiple biological processes by controlling cell proliferation, apoptosis, differentiation, and metabolism. Especially, c-Myc is frequently overexpressed in many human cancers and widely involved in tumorigenesis.
Beibei, Mao, Guowei, Zhao, Xiang, Lv, Hou-Zao, Chen, Zheng, Xue, Ben, Yang, De-Pei, Liu, Chih-Chuan, Liang   +7 more
openaire   +2 more sources

Association with C-Myc: An Alternated Mechanism for c-Myc Function

1995
The c-myc proto-oncogene encodes a ubiquitously expressed nuclear phospho-protein that is involved in the control of cellular proliferation and differentiation (1, 2, 3). Alteration of the c-myc locus by chromosomal translocation, amplification or retroviral insertion is often associated with tumorigenesis in different species including humans (1, 3 ...
A, Shrivastava, K, Calame
openaire   +2 more sources

c-Myc-Induced Genomic Instability

Journal of Environmental Pathology, Toxicology and Oncology, 2003
c-myc is one of a small family of proto-oncogenes that do not require mutation to contribute to neoplastic transformation. Instead, the deregulated expression of the oncoprotein at even modest levels is sufficient to initiate this process. The transforming activity of c-Myc is generally thought to lie in its ability to modulate the expression of a ...
Sabine, Mai, J Frederic, Mushinski
openaire   +2 more sources

c-myc amplification in ovarian cancer

Gynecologic Oncology, 1990
The c-myc oncogene codes for a DNA binding protein that appears to play an important role in the regulation of cell growth. c-myc gene amplification has been documented to occur in both hematopoietic and solid neoplasms and often indicates more biologically aggressive tumors.
V V, Baker, M P, Borst, D, Dixon, K D, Hatch, H M, Shingleton, D, Miller   +5 more
openaire   +2 more sources

Identification of c-MYC as a target of the APC pathway.

Science, 1998
T. He, A. Sparks, C. Rago, H. Hermeking, L. Zawel, L. D. Costa, P. Morin, B. Vogelstein, K. Kinzler   +8 more
semanticscholar   +1 more source

c-Myc-regulated microRNAs modulate E2F1 expression

Nature, 2005
Kathryn A. O’Donnell, E. Wentzel, K. Zeller, C. Dang, J. Mendell   +4 more
semanticscholar   +1 more source

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

Nature, 1988
D. Vaux, S. Cory, Jerry M. Adams
semanticscholar   +1 more source

???????????????????? ???????????????? c-myc ?? ?????????????? ???????????????? ?????????????????? ????????????

2019
?????????????????? ???????????????????????????? ???????????????????????????? ?????????????????????? ?????????????????? ?????????????????? ???????????????? ?????????????????? ???????????? ???? ???????????? ???????????????????? ??????????. ???????????????? ?????????????????? ?????????????????? ???????????? ?????????????????????? ???? 1 g ?? 0???0,3 ?? ???
openaire   +1 more source

Induction of apoptosis in fibroblasts by c-myc protein

Cell, 1992
G. Evan, A. Wyllie, C. Gilbert, T. Littlewood, H. Land, M. Brooks, C. Waters, L. Penn, D. Hancock   +8 more
semanticscholar   +1 more source