Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston+7 more
wiley +1 more source
Evolutionary interplay between viruses and R‐loops
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi+4 more
wiley +1 more source
Clinical relevance of high sensitivity C-reactive protein in cardiology
Coping with cardiovascular diseases (CVD), which are of the main causes of death worldwide, has influenced investigation of high sensitivity CRP (hsCRP) and its role in pathogenesis, prognosis and prevention of CVD.
Dalia Adukauskienė+5 more
doaj +1 more source
Thrombocytopenia in end-stage renal disease and chronic viral hepatitis B or C [PDF]
Objectives. We evaluated platelet counts in end-stage renal disease and chronic viral hepatitis. Materials and Methods. We studied 70 patients with end-stage renal disease and chronic viral hepatitis and compared them to a control group of 45 patients ...
Breaban, Iulia+12 more
core +1 more source
Fibrates and C-reactive protein
Clin Chim ...
Kostoula, A., Elisaf, M. S.
openaire +3 more sources
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt+8 more
wiley +1 more source
Real time detection of C reactive protein in interstitial fluid using electrochemical impedance spectroscopy, towards wearable health monitoring [PDF]
Traditional detection methods of C-reactive protein (CRP) inflammation biomarker, in blood are expensive, time-consuming and labor-intensive. Such existing point-of-care CRP detection devices remain invasive, since they need blood sampling (finger-pricking or venous puncture).
arxiv
A new high-sensitive nephelometric method for assaying serum C-reactive protein based on phosphocholine interaction [PDF]
Background: The measurement of C-reactive protein (CRP) concentrations has been of interest as a classical marker of acute phase response; in addition, it has been of particular interest in cardiovascular risk stratification where high-sensitive ...
Alsaadi, Hani+3 more
core +1 more source
Comparison of the Erythrocyte Sedimentation Rate, C-Reactive Protein, Serum Diphenylamine, and Tetrammonium Tests in Rheumatic Fever and Rheumatic Heart Disease [PDF]
R. D. Eastham, P. Székely, Kade Davison
openalex +1 more source
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever+1 more
wiley +1 more source