Results 171 to 180 of about 1,151,537 (267)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Associations of circulating c-reactive protein levels with central Alzheimer's disease biomarkers. [PDF]

J Prev Alzheimers Dis
Choi HJ, Byun MS, Yi D, Ahn H, Jung G, Park S, Jung JH, Keum M, Sohn BK, Kim YK, Choi H, Lee YS, Lee JY, Kang KM, Sohn CH, Huang YN, Saykin AJ, Nho K, Lee DY, KBASE Research Group.   +19 more
europepmc   +1 more source

Plasma Levels of Soluble Thrombomodulin, C-reactive Protein, and Serum Amyloid A Protein in the Atherosclerotic Coronary Circulation

, 2003
Tohru Mezaki, Taku Matsubara, Tomoyuki Hori, Kohtarou Higuchi, Akira Nakamura, Iwao Nakagawa, Shunsuke Imai, Kazuyuki Ozaki, Keiichi Tsuchida, Akimitsu Nasuno, Takayuki Tanaka, Kaname Kubota, Masahiko Nakano, Takashi Miida, Yoshifusa Aizawa   +14 more
openalex   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Association of C-reactive protein to albumin ratio with prevalence and mortality in metabolic syndrome: NHANES 1999-2010. [PDF]

Eur J Med Res
Wang L, Liu C, Zheng X, Wang A, Lin Y, Peng F.   +5 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Integrating C-reactive protein flare and early MRI dynamics for enhanced prediction of immunotherapy response. [PDF]

J Immunother Cancer
Navarro-Garcia D, Grussu F, Zatse C, Klümper N, Macarro C, Hernando-Calvo A, Sanz M, Vieito M, Braña I, Mirallas O, Alonso G, Galvao V, Pretelli G, Lostes J, Oberoi A, Toledo R, Nuciforo P, Garralda E, Perez-Lopez R.   +18 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Predictive Value of C-Reactive Protein/Albumin Ratio in Acute Pancreatitis. [PDF]

Cureus
Khanal N, Baral A, Shrestha S, Lakhey PJ, Bhandari RS.   +4 more
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source