Results 61 to 70 of about 22,768,139 (291)

C-reactive protein in aortic valve disease

Cardiovascular Ultrasound, 2006
Aortic Valve Disease, includes a range of disorder severity from mild leaflet thickening without valve obstruction, "aortic sclerosis", to severe calcified aortic stenosis.
Mazzone Anna, Sanchez Pedro L
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

High-sensitivity C-reactive protein concentrations among patients with and without diabetes in a multiethnic population of Singapore: CREDENCE Study

Diabetes, Metabolic Syndrome and Obesity, 2010
Rinkoo Dalan1, Michelle Jong1, Siew-Pang Chan4,5, Robert Hawkins2, Robin Choo6, Brenda Lim1, May L Tan3, Melvin KS Leow1,61Department of Endocrinology, 2Department of Laboratory Medicine, 3Health Enrichment Centre, Tan Tock Seng Hospital, Singapore ...
Rinkoo Dalan, Michelle Jong, Siew-Pang Chan, et al   +3 more
doaj  

C-Reactive Protein Serum Levels After Seizures

Pediatric Neurology Briefs, 2012
Investigators at Tampere University Hospital, Finland measured C-reactive protein (CRP) serum concentrations in 31 patients (mean age 34, range 6-58 years) with refractory focal epilepsy while undergoing video-EEG monitoring and compared with 80 healthy ...
J Gordon Millichap
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease [PDF]

, 2010
Background: Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events ...
Adam D Timmis, Kate S L McAllister, Fitzpatrick Natalie K., J. Damant (7608818), Stephen Palmer, McAllister, Kate, Aroon D Hingorani, A. D. Timmis (7608830), Hingorani, AD, Chen Ruoling, A. D. Hingorani (7602500), Damant Jacqueline, Fitzpatrick, NK, Timmis Adam D., Keith R. Abrams, J. C. Kaski (7608827), Palmer, S, Fitzpatrick, Natalie K., Chen, Ruoling, Abrams, Keith R, Harry Hemingway, Timmis, Adam D, Philipson, P, Santiago Moreno, Natalie K. Fitzpatrick, Palmer, Stephen, Turnbull, Fiona Mary, McAllister, Kate S L, Damant, J, Timmis, Adam D., K. S. L. McAllister (7608824), Moreno, Santiago, Kaski, JC, Philipson Peter, Hingorani, Aroon D, Hemingway Harry, Adam D. Timmis, Fitzpatrick, Natalie K, Abrams Keith R., Keith R. Abrams (7579436), Shipley, Martin, Palmer Stephen, Hemingway, Harry, Shipley Martin, Abrams, Keith R., Chen, R, H. Hemingway (7608809), McAllister, KSL, Shipley, M, Timmis, AD, Moreno Santiago, Natalie K Fitzpatrick, Hingorani Aroon D., Damant, Jacqueline, Juan Carlos Kaski, Fitzpatrick, Natalie, Philipson, Peter, McAllister, KS, N. K. Fitzpatrick (7608815), Kaski Juan Carlos, P. Philipson (7608812), Abrams, Keith, Kate S. L. McAllister, S. Palmer (3693193), Martin Shipley, Peter Philipson, Jacqueline Damant, M. Shipley (7608821), McAllister Kate S. L., Santiago Moreno (90184), Chen, RL, Moreno, S, Mcallister, Katherine, Abrams, KR, R. Chen (576618), Hingorani, Aroon D., Kaski, Juan Carlos, Keith R Abrams, Hemingway, H, Timmis, Adam, Aroon D. Hingorani, Ruoling Chen, Philipson, Pete, Hingorani, Aroon   +83 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Procalcitonin or C-Reactive Protein: The better Identifier of Treatment Response in Urinary Tract Infection among Adults

Pakistan Armed Forces Medical Journal
Objective: To ascertain the better marker between Procalcitonin and C reactive protein (CRP) in predicting response of treatment in patients suffering from urinary tract infections. Study Design: Comparative cross sectional study. Place and Duration
Umer Naseer, Abdul Rehman Arshad, Bassam Khalid, Taimoor Saleem, Fatima Naseer, Mahnoor Qamar   +5 more
doaj   +1 more source