Results 101 to 110 of about 99,706,347 (248)

Diagnostic possibilities of composite inflammatory indexes in purulent-septic surgical diseases

Вестник анестезиологии и реаниматологии
Introduction. The emergence of new composite (incorporated, combined, aggregated) indices that allow simultaneously evaluating inflammation, nutrition, and immunity is being actively studied as a risk factor for severe cardiovascular, oncological, and ...
Yu. Yu. Kiryachkov
doaj   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

The Diagnostic Accuracy of Neutrophil-to-Lymphocyte Ratio (NLR) Compared to C-Reactive Protein (CRP) in Patients with Acute Cholecystitis: A Systematic Review and Meta-Analysis

Diagnostics
Background/Objectives: Acute cholecystitis is associated with an increased risk of morbidity and mortality. Thus, early diagnosis and detection of complications are essential.
Raluca-Ioana Șerban, Isaic Alexandru, Cristi Tarta, Faur Flaviu-Ionut, Duta Ciprian, Alexandru Catalin Motofelea, Dobrescu Amadeus Emanuel   +6 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

C-Reactive Protein/Albumin and Neutrophil/Albumin Ratios as Novel Inflammatory Markers in Patients with Schizophrenia

, 2020
Objective Peripheral biomarker studies in schizophrenia are insufficient to correspond to whether inflammatory markers are trait- or state-related. The main objective of this study was to compare novel biomarkers C-reactive protein/albumin ratio (CAR ...
Balcioglu, Yasin Hasan, Kirlioglu, Simge Seren, Simge Seren Kirlioglu, Yasin Hasan Balcioglu   +3 more
core   +1 more source

Prognostic role of lymphocyte-to-C reactive protein ratio in hepatocellular carcinoma (HCC): A meta-analysis of 4,006 patients

Asian Journal of Surgery, 2023
Zhengyue He, Boan Lai, Hui Jiang, Ling Yang   +3 more
doaj   +1 more source

Neutrophil-lymphocyte ratio as a point-of-care marker for predicting bacterial etiology in pediatric community-acquired Pneumonia: A comparative analysis with C -reactive protein

Clinical Epidemiology and Global Health
Objectives: To evaluate the role of NLR in predicting bacterial etiology in pediatric community acquired pneumonia and compare its diagnostic performance with CRP.
Maya Lakshmanan, Sandeep Kumar, Sowmya Shashidhara, Pushpa Kini, Shrikiran Aroor, Suneel Mundkur, Ramesh Bhat Y, Karen Moras   +7 more
doaj   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source