Results 71 to 80 of about 45,573,897 (286)
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Effect of Gluconate Molecules on the Reaction Kinetics of C-(N)-A-S-H and N-A-S-H Gel Formation
Organic ligands are widely used to regulate setting in cementitious binders, yet their chemistry-selective action in geopolymers (GPs) remains unclear. Here we isolate the role of sodium gluconate (SG) in early reaction kinetics across a Ca-rich GP that ...
Zhang, Zuhua +8 more
core +1 more source
BuildingsSuperabsorbent polymers (SAPs) are widely employed as an internal curing agent to enhance the durability and shrinkage–cracking resistance of concrete.
Shengbo Zhou +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Materiales de ConstruccionThis study examines how calcium aluminate cement (CAC) and calcium sulfate influence the hydration and gel structure of Portland cement (PC). A binary PC/CAC (85/15) mix was compared with ternary systems containing 3% and 5% calcium sulfate under two ...
D. Torrens-Martín +1 more
doaj +1 more source
Decoding the structural origin of creep in C–S–H gels by machine learning
, 2021 This publication is part of the proceedings of the Biot-Bažant Conference on Engineering Mechanics and Physics of Porous Materials, which took place virtually on June 1-3, 2021. It contains a one-page abstract and the video of the talk that was given at the conference.
Liu, H., Bauchy, M.
openaire +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
INFLUENCE OF FLY ASH REPLACEMENT RATIO ON COMPOSITIONS OF C-S-H GEL [PDF]
, 2020 This study reports the effect of fly ash replacement ratio on composition of C-S-H gel. The compositions of C-S-H gel were estimated by combination of Rietveld/XRD analysis, selective dissolution and ignition loss.
Daisuke Minato +3 more
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