Results 51 to 60 of about 28,666,794 (72)

Pharmacologically Antagonizing the CXCR4-CXCL12 Chemokine Pathway with AMD3100 Inhibits Sunlight-Induced Skin Cancer [PDF]

, 2014
One way sunlight causes skin cancer is by suppressing anti-tumor immunity. A major mechanism involves altering mast cell migration via the C-X-C motif chemokine receptor 4–C-X-C motif chemokine ligand 12 (CXCR4-CXCL12) chemokine pathway.
Byrne, Scott N., Beaugie, Clare, Marsh-Wakefield, Felix, Halliday, Gary M., Sarchio, Seri Narti Edayu, Scolyer, Richard A., Sarchio, Seri N.E., McDonald, David   +7 more
core   +1 more source

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

iMetaMed, Volume 2, Issue 3, September 2026.
A pan‐cancer atlas deciphers tumor‐induced reprogramming in bone metastases. Malignant evolution toward MYC/proliferation is a hallmark of bone metastases. Niche‐mediated immune dysfunction is characterized by immature pDCs, impaired antigen presentation and phagocytosis in TAMs, and exhausted T cells.
Yitong Pan, Zhou Yang, Junyuan Deng, Feng Liu, Guang Lei   +4 more
wiley   +1 more source

Black phosphorus‐based photothermal disruption of cancer‐associated fibroblast barriers and tumor‐associated macrophage targeting to enhance anti‐PD‐L1 immunotherapy in triple‐negative breast cancer

Interdisciplinary Medicine, Volume 4, Issue 5, September 2026.
MBB modulates the TNBC tumor microenvironment by targeting TAM/CXCL1 and facilitates anti‐PD‐L1 therapy by disrupting CAF barriers via its photothermal effect. This combined strategy subsequently enhances the efficacy of PD‐L1 mAb and suppresses TNBC progression, metastasis, and recurrence.
Bo Pan, Shicui Hong, Xinyue Wang, Yanghang Li, Cai Wang, Yaxiao Liu, Ying Chen, Chen Fang, Yifeng Zheng, Shengqi Wang, Juping Zhang, Neng Wang, Zhiyu Wang   +12 more
wiley   +1 more source

CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR [PDF]

, 2016
To evaluate the possible crosstalk between C-X-C chemokine receptor 4 (CXCR4)/C-X-C motif chemokine 12 (CXCL12)/C-X-C chemokine receptor 7 (CXCR7) axis with the mammalian target of rapamycin (mTOR) pathway in neuroendocrine tumors (NETs)
SCIAMMARELLA, CONCETTA, COLAO, ANNAMARIA, FAGGIANO, ANTONGIULIO, DEL BASSO DE CARO, MARIALAURA, Pezzullo, Luciano, Circelli, Luisa, Simona Losito, Nunzia, CILIBERTO, GENNARO, Botti, Giovanni, ARIA, MASSIMO, D'Alterio, Crescenzo, GUADAGNO, ELIA, IZZO, FRANCESCO, SCALA, STEFANIA, Tafuto, Salvatore, Tatangelo, Fabiana, Ieranò, Caterina, RAMUNDO, VALERIA, Losito, Nunzia Simona   +18 more
core   +1 more source

Transcriptional Profiling of Growth Hormone–Secreting Pituitary Adenoma Stem‐Like Cells: Unveiling the Significant Role of CXCR4 in Tumorigenesis and Clinical Applications

MedComm, Volume 7, Issue 9, September 2026.
Growth hormone–secreting pituitary adenomas harbor hPASCs (human pituitary adenoma stem‐like cells). Genetic profiling of hPASCs identified CXCR4 as a significant gene orchestrating a regulatory network in the self‐renewal and differentiation of hPASCs, as well as the modulation of tumor cells and the microenvironment.
LinHao Yuan, Hao Yang, BaoWang Li, Huimin Sui, Peiliang Li, Xu Wang, Jiang Li, Guijun Jia, Zhaohui Zhu, Deling Li, Wang Jia, Peng Kang   +11 more
wiley   +1 more source

C–C motif chemokine ligand 2/C–C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.
Xuyi Chen, Cheng Yang, Yingkai Wang, Xiangzi Wang, Zhongquan Qi, Xiaofei Niu, Yang Liu   +6 more
core   +1 more source

HIGH CIRCULATING CHEMOKINES (C-X-C MOTIF) LIGAND 9, AND (C-X-C MOTIF) LIGAND 11, IN HEPATITIS C-ASSOCIATED CRYOGLOBULINEMIA

, 2013
(C-X-C motif) ligand 9 and (C-X-C motif) ligand 11 (CXCL9 and CXCL11), are potent chemo attractants for activated T cells, and play an important role in T helper 1 (Th)1 cell recruitment in chronic hepatitis C. No study has evaluated CXCL9, together with
Sansonno D, Frascerra S, Zignego AL, Colaci M, Ferri C., SANSONNO, Domenico Ettore, Antonelli A, Fallahi P, ANTONELLI, ALESSANDRO, Ferrari SM, Manfredi A, Mancusi C   +11 more
core   +2 more sources

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling

, 2019
As an -chemokine receptor specific for stromal-derived-factor-1 (SDF-1, also called CXCL12), C-X-C chemokine receptor type 4 (CXCR4) plays a vital role in chemotactically attracting lymphocytes during inflammation.
Travis Lear (6430345), Yuan Liu (6430355), John Evankovich (6430353), Aazrin Mir (6430352), Alison C. McKelvey (6430350), Beibei Chen (6430356), Sarah R. Dunn (6430347)   +6 more
core   +1 more source

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source