Results 61 to 70 of about 28,666,794 (72)

Natalizumab Antibodies and C-X-C Motif Chemokine Ligand 13 Serum Levels in Multiple Sclerosis Patients [PDF]

Background: Natalizumab is a humanized monoclonal antibody that is an established therapy for relapsing–remitting multiple sclerosis (RRMS). A fraction of patients, however, form anti-drug antibodies that have the potential to lessen the efficacy of ...
Shaheed, Nawfal Mahdi, Mohammed, Hadeel Abood, Abbas, Ahmed Abdul-Hassan   +2 more
core   +1 more source

Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]

, 2005
Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders, Ninichuk, Volha, Anders, Hans-Joachim, Volha Ninichuk   +3 more
core   +1 more source

Proteomic profile of CSF obtained at the time of diagnosis determines amyotrophic lateral sclerosis progression and survival: CXCL7 levels in disease prognosis and survival

Brain Pathology, Volume 36, Issue 5, September 2026.
Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira, Yaiza López‐Sampere, Pol Mengod‐Soler, Mario Peña‐Fonteboa, Carla Marco, Alejandro Caravaca‐Puchades, Raúl Domínguez, Juan Francisco Vázquez‐Costa, Enrique Santamaría, Joaquín Fernández‐Irigoyen, María J. Colomina, Isabel León Moreno, Antonio Martínez Yélamos, Sergio Martínez Yélamos, Gabriel Santpere, Elia Obis, Manuel Portero‐Otín, Gerard Piñol‐Ripoll, Mónica Povedano, Pol Andrés‐Benito   +19 more
wiley   +1 more source

The k-junction motif in RNA structure [PDF]

, 2014
The k-junction is a structural motif in RNA comprising a three-way helical junction based upon kink turn (k-turn) architecture. A computer program written to examine relative helical orientation identified the three-way junction of the Arabidopsis TPP ...
Daldrop, Peter, Jia Wang, Lilley, David M. J.; id_orcid, Peter Daldrop, David M. J. Lilley, Wang, Jia, Huang, Lin, Lin Huang   +7 more
core   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, Volume 293, Issue 17, Page 5107-5120, September 2026.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

C-X-C Motif Chemokine 12 Was Identified as a Potential Gene Target in the Treatment of Crohn’s Disease

Hongsai Hu, Rong He, Minji Liu, Hongbing Zhou, Lin Tan, Qiongjia Ai, Qian Wang, Luwei Zeng, Weiming Qu Department of Gastroenterology, Zhuzhou Hospital Affiliated to Xiangya Medical College, Central South University, Zhuzhou, 412000, People’s Republic of
Tan L, Wang Q, Liu M, Ai Q, Zeng L, Hu H, He R, Zhou H, Qu W   +8 more
core  

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26

, 2016
A population of stromal cells, myeloid-derived suppressor cells (MDSCs), is present in tumors. Though studies have gradually revealed the protumorigenic functions of MDSCs, the molecular mechanisms guiding MDSC recruitment remain largely elusive. Hypoxia,
Xu, M, Wong, CM, Koh, HY, Chiu, KC, Wong, CCL, Wei, L, Lee, D, Tse, PW, Li, LL, Lo, CLR, Ng, IOL, Lai, KH   +11 more
core   +1 more source

The potential O-linked glycosylation sites of C-X-C chemokine receptor type 4 mediate bone marrow homing of hematopoietic stem progenitor cells

The C-X-C chemokine receptor type 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), are critical for the homing of hematopoietic stem progenitor cells (HSPCs) to bone marrow (BM).
Pan, Xuchi
core   +1 more source

RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling

, 2017
As an α-chemokine receptor specific for stromal-derived-factor-1 (SDF-1, also called CXCL12), C-X-C chemokine receptor type 4 (CXCR4) plays a vital role in chemotactically attracting lymphocytes during inflammation. CXCR4 also regulates HIV infection due
John Evankovich, Yuan Liu, Travis Lear, Alison C. McKelvey, Aazrin Mir, Sarah R. Dunn, Bill B. Chen   +6 more
core   +1 more source

CXCL12 (chemokine (C-X-C motif) ligand 12)

, 2015
Review on CXCL12, with data on DNA, on the protein encoded, and where the gene is ...
Maria Guarnaccia, Giulia Gentile, Sebastiano Cavallaro   +2 more
core