Results 1 to 10 of about 63,476 (182)

Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses [PDF]

Nature Communications
Overactivation of FcγRI by immune complexes (IC) is implicated in various autoimmune disorders and neuropathies. Currently, no effective FcγRI-specific blocking antibodies are available. Here we report preclinical data revealing two anti-FcγRI antibodies,
Tosca Holtrop, Arianne M. Brandsma, Louris J. Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M. Passchier, Maaike Nederend, J. H. Marco Jansen, Anouk G. van Mourik, Rolf T. Urbanus, Diane van der Woude, Roger E. G. Schutgens, Rene E. M. Toes, Bert J. C. Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H. W. Leusen   +20 more
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Intravitreal Gene Therapy with LX102-C01 in Neovascular Age-Related Macular Degeneration: A Phase I Dose-Escalation Study of 12-Month Safety and Efficacy Outcomes [PDF]

Ophthalmology Science
Purpose: To assess the safety, tolerability, and preliminary efficacy of a single intravitreal injection of LX102-C01 in eyes with neovascular age-related macular degeneration (nAMD) followed up to 52 weeks.
Junran Sun, Mengxi Shen, Jieqiong Chen, Yidong Wu, Yanping Zhou, Jingyang Feng, Yuxuan Cheng, Huixun Jia, Xiaolu Yang, YuanYuan Gong, Yang Liu, Hong Wang, Ruikang K. Wang, Philip J. Rosenfeld, Tong Li, Fenghua Wang, Xiaodong Sun   +16 more
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Epinephrine Affects Ribosomes, Cell Division, and Catabolic Processes in Micrococcus luteus Skin Strain C01: Revelation of the Conditionally Extensive Hormone Effect Using Orbitrap Mass Spectrometry and Proteomic Analysis

Microorganisms, 2023
In the current study, extensive Orbitrap mass spectrometry analysis was conducted for skin strain Micrococcus luteus C01 planktonic cultures and biofilms after 24 h and 72 h of incubation either in the presence of epinephrine or without any ...
Andrei V. Gannesen, Rustam H. Ziganshin, Maria A. Ovcharova, Ekaterina D. Nevolina, Alena I. Klimko, Sergey V. Martyanov, Vladimir K. Plakunov   +6 more
doaj   +1 more source

Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Clinical treatment by FDA-approved ROS1/ALK inhibitor Crizotinib significantly improved the therapeutic outcomes. However, the emergence of drug resistance, especially driven by acquired mutations, have become an inevitable problem and worsened the ...
Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang   +12 more
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Natural product nanofibers derived from Trichoderma hamatum K01 to control citrus anthracnose caused by Colletotrichum gloeosporioides

Open Agriculture, 2023
The antifungal activity of Trichoderma hamatum K01 to control Colletotrichum gloeosporioides C01 was recorded. Pathogenicity of C. gloeosporioides C01 on citrus leaves was confirmed by the Koch postulate. T.
Phal Pheaktra, Soytong Kasem, Poeaim Supattra   +2 more
doaj   +1 more source

Molecular marking in breeding Brassica oleracea L. for resistance to Xanthomonas campestris pv. campestris [PDF]

E3S Web of Conferences, 2021
In the presented study, we have studied polymorphism of 30 microsatellite loci in terms of resistance to black rot (Xanthomonas campestris). Three SSR markers (Ol10-C01, Ol11-H06, BoESSR 726) were identified, showing polymorphism in white cabbage forms ...
Makukha Yuliya, Dubina Elena
doaj   +1 more source

Impact of monetary policy transmission mechanism in West African countries

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2022
The study analyzed the impact of monetary policy shocks on economic growth in 12 countries of the Economic Community of West African States (ECOWAS), using quarterly data from 1980(1) to 2017(4).
Famoroti Jonathan Olusegun, Adeleke Omolade   +1 more
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Determinants of International Tourism Demand in India: An Augmented Gravity Model Approach

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2022
This study examines the determinants of international tourism demand in India using time series data from 1991-2019 from the top 15 source tourist countries. To do this, the study employed an augmented gravity model estimated using a two-step panel fixed-
Shah Imtiyaz Ahmad, Nengroo Tariq Ahad, Haq Imtiyaz ul   +2 more
doaj   +1 more source

The Examination of the Relationship Between Foreign Direct Investment and Trade in Turkey: ARDL Approach

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2023
This paper is aimed to examine the effect of Foreign Direct Investment inflow on Trade (Export, Import) in Turkey. The study copes the time span from 2006 Q2 to 2019 Q4. The time series datasets, those are retrieved from CBT and FRED database are used in
Ilham Karimov Mehman, Vaqif Nesirov Elcin, Calal Zeynalli Elay   +2 more
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The Impact of Operating Cash Flow and Current Ratio on the Profitability in Construction Industry

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice, 2020
The quality of works and a good reputation on the market are the main factors that lead to the success of a construction business. That is why most of the projects carried out in this sector involve the provision of performance guarantees which are ...
Pordea Daniela, David Delia, Mateș Dorel   +2 more
doaj   +1 more source