Results 21 to 30 of about 76,513 (294)

Discovery of dual tubulin-NEDDylation inhibitors with antiproliferative activity

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2023
Although various dual-target tubulin inhibitors have been designed and synthesised, no dual tubulin-NEDDylation inhibitors as antiproliferative agents were reported so far.
Dong-Jun Fu, Ting Wang
doaj   +1 more source

GPR52 accelerates fatty acid biosynthesis in a ligand-dependent manner in hepatocytes and in response to excessive fat intake in mice

open access: yesiScience, 2021
Summary: Gpr52 is an orphan G-protein-coupled receptor of unknown physiological function. We found that Gpr52-deficient (Gpr52−/−) mice exhibit leanness associated with reduced liver weight, decreased hepatic de novo lipogenesis, and enhanced insulin ...
Mitsuo Wada   +8 more
doaj   +1 more source

Verifying C11-style weak memory libraries [PDF]

open access: yesProceedings of the 26th ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming, 2021
Deductive verification of concurrent programs under weak memory has thus far been limited to simple programs over a monolithic state space. For scalabiility, we also require modular techniques with verifiable library abstractions. This paper addresses this challenge in the context of RC11 RAR, a subset of the C11 memory model that admits relaxed and ...
Sadegh Dalvandi, Brijesh Dongol
openaire   +3 more sources

Owicki-Gries Reasoning for C11 RAR (Artifact) [PDF]

open access: yes, 2020
The paper "Owicki-Gries Reasoning for C11 RAR" introduces a new proof calculus for the C11 RAR memory model that allows Owicki-Gries proof rules for compound statements, including non-interference, to remain unchanged.
Wehrheim, Heike   +3 more
core   +1 more source

Gestión de la tecnología e innovación: un Modelo de Redes Bayesianas

open access: yesEconomía Teoría y Práctica, 2019
La presente investigación tiene como propósito fundamental estudiar y analizar la gestión de la tecnología e innovación a través de Redes Bayesianas, para lo cual se realiza un modelo en el que se identifican y cuantifican los diversos factores que ...
Antonia Terán Bustamante   +2 more
doaj   +1 more source

Biosurfactant Production by Bacillus amyloliquefaciens C11 and Streptomyces lavendulae C27 Isolated from a Biopurification System for Environmental Applications

open access: yesMicroorganisms, 2022
Biosurfactant-producing bacteria can be found in contaminated environments such as biopurification systems (BPS) for pesticide treatments. A total of 18 isolates were screened to determine their ability to produce extracellular biosurfactants, using ...
M. Cristina Diez   +5 more
doaj   +1 more source

A new link function for the prediction of binary variables

open access: yesCroatian Review of Economic, Business and Social Statistics, 2018
If there are no heavy sanctions in place to prevent it, the problem of the cancellation of appointments can lead to huge economic losses and can have a significant impact on underutilized resources of healthcare facilities.
Gheno Gloria
doaj   +1 more source

Owicki-Gries Reasoning for C11 Programs with Relaxed Dependencies ⋆ [PDF]

open access: yes, 2021
Deductive verification techniques for C11 programs have advanced significantly in recent years with the development of operational semantics and associated logics for increasingly large fragments of C11.
dongol, Brijesh
core   +1 more source

Chemometrics, health risk assessment and probable sources of soluble total petroleum hydrocarbons in atmospheric rainwater, Rivers State, Nigeria

open access: yesScientific Reports, 2022
Total petroleum hydrocarbons (TPHs)—(aliphatic and aromatic) were analysed for in atmospheric rainwater between April–June; July–August; September–October depicting early, mid, late rain of 2019.
Daniel Omeodisemi Omokpariola   +4 more
doaj   +1 more source

Diarylamine-Guided Carboxamide Derivatives: Synthesis, Biological Evaluation, and Potential Mechanism of Action

open access: yesFrontiers in Chemistry, 2022
Diarylamines are a class of important skeleton widely existing in drugs or natural products. To discover novel diarylamine analogues as potential drugs, two series of diamide and carboxamide derivatives containing diarylamine scaffold were designed ...
Shaoyong Ke   +11 more
doaj   +1 more source

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