Results 191 to 200 of about 123,149 (251)

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

open access: yesThe FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Seasonal variation in preen gland secretions of Tristram's Storm Petrel (Hydrobates tristrami)

open access: yesIbis, EarlyView.
Preen gland secretions are known to vary depending on sex, season and species and are thought to play essential roles in avian life history. However, their chemical composition and functions remain largely unclear in Procellariiform seabirds with well‐developed olfactory senses. Storm petrels, known for their distinctive body odour, may use preen gland
Taiki Terajima   +2 more
wiley   +1 more source

Hypercapnia Induces Mitochondrial Adaptations and Alters Glutamine Metabolism to Drive a Distinct Metabolic Phenotype in Monocytes

open access: yesImmunology &Cell Biology, EarlyView.
Elevated CO2 (hypercapnia) is a feature of serious lung diseases, for example COPD and contributes to poor patient prognosis through modulation of immune cell function. Here we employ state‐of‐the art metabolomic and isotope tracing approaches to reveal CO2‐dependent mitochondrial alterations linked to suppressed ATP, proline and glutamate levels in ...
Ben Reddan   +5 more
wiley   +1 more source

Demand Shocks, Export Diversification, and Firm Performance During the Great Trade Collapse

open access: yesJournal of Economics &Management Strategy, EarlyView.
ABSTRACT This paper analyzes the impact of external demand shocks from the 2008 to 2009 Great Trade Collapse on the performance of Chinese exporters and examines how export diversification mitigates these effects. Using Chinese Customs data merged with financial data from all listed Chinese firms, we construct firm‐specific demand shocks based on pre ...
Qianlin Hong   +3 more
wiley   +1 more source

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