Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
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Crystal structure and Hirshfeld surface analyses, inter-action energy calculations and energy frameworks of (<i>Z</i>)-4-benzyl-2-(4-methyl-benzylidene)-2<i>H</i>-[1,4]benzo-thia-zin-3(4<i>H</i>)-one. [PDF]
Hni B +6 more
europepmc +1 more source
Seasonal variation in preen gland secretions of Tristram's Storm Petrel (Hydrobates tristrami)
Preen gland secretions are known to vary depending on sex, season and species and are thought to play essential roles in avian life history. However, their chemical composition and functions remain largely unclear in Procellariiform seabirds with well‐developed olfactory senses. Storm petrels, known for their distinctive body odour, may use preen gland
Taiki Terajima +2 more
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Crystal structure and Hirshfeld surface analysis of 1-(furan-2-yl)-2-(thio-phene-2-carbon-yl)-3-(thio-phen-2-yl)-2,3,3a,8a-tetra-hydro-cyclo-penta-[<i>a</i>]inden-8(1<i>H</i>)-one. [PDF]
Gezegen H +4 more
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Demand Shocks, Export Diversification, and Firm Performance During the Great Trade Collapse
ABSTRACT This paper analyzes the impact of external demand shocks from the 2008 to 2009 Great Trade Collapse on the performance of Chinese exporters and examines how export diversification mitigates these effects. Using Chinese Customs data merged with financial data from all listed Chinese firms, we construct firm‐specific demand shocks based on pre ...
Qianlin Hong +3 more
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Mol-ecular and crystal structure of <i>catena</i>-poly[1-benzyl-[1,2,4]triazolo[1,5-<i>c</i>]quinazolin-1-ium-2,5-bis-(thiol-ate) [[aqua-sodium]-di-μ-aqua]]. [PDF]
Shishkina SV +5 more
europepmc +1 more source
Abstract Seafood provides an essential source of macro‐ and micronutrients for coastal communities worldwide. Climate change is a key threat to seafood security, altering the sizes, abundances, distributions, physiology and ecological interactions of fisheries species, and increasingly, there is evidence of impacts to seafood nutritional quality.
Tanika C. Shalders +6 more
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Synthesis, crystal structure and Hirshfeld surface analysis of 2-oxo-<i>N</i>-(pyridin-4-yl)-2<i>H</i>-chromene-3-carboxamide. [PDF]
Sunithakumari M +5 more
europepmc +1 more source
Obesity Modifies Sphingolipid Signatures in Childhood Asthma
Clinical &Experimental Allergy, EarlyView.
Harshita Shailesh +7 more
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