Results 51 to 60 of about 123,149 (251)

Beyond Parametric Bounds: Exploring Regional Unemployment Patterns Using Semiparametric Spatial Autoregression

open access: yesBusiness Systems Research
It is a well-known phenomenon that nonlinearities that are inherent in the relationship among economic variables negatively affect the commonly used estimators in the econometric models. The nonlinearities cause an instability of the estimated parameters
Furková Andrea, Knížat Peter
doaj   +1 more source

AHL-Priming Protein 1 mediates N-3-oxo-tetradecanoyl-homoserine lactone priming in Arabidopsis

open access: yesBMC Biology, 2022
Background N-3-oxo-tetradecanoyl-L-homoserine lactone (oxo-C14-HSL) is one of the N-acyl homoserine lactones (AHL) that mediate quorum sensing in Gram-negative bacteria.
Abhishek Shrestha   +6 more
doaj   +1 more source

New Syntheses of E7389 C14−C35 and Halichondrin C14−C38 Building Blocks: Double-Inversion Approach

open access: yes, 2016
With sequential use of catalytic asymmetric Cr-mediated coupling reactions, E7389 C14−C35 and halichondrin C14−C38 building blocks have been stereoselectively synthesized.
Cheng-Guo Dong (2340592)   +6 more
core   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

open access: yesAdvanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer   +9 more
wiley   +1 more source

Evaluación de la gestión privada del servicio público educativo en Medellín

open access: yesLecturas de Economía, 2007
La alcaldía de Medellín emprendió en 2002 un programa de cobertura educativa dirigido a jóvenes en edad escolar en lugares donde la oferta escolar pública era reducida.
Jorge Barrientos, Paul Rios
doaj  

BANADORA, des années 1990 à aujourd’hui. Refonte du Système d’Informations du Centre de Datation RadioCarbone (C14)

open access: yes
International audienceIn the 1990s, the Radiocarbon Dating Center (C14) initiated a database of conducted C14 datings to make them accessible to a wider audience. Accelerator Mass Spectrometry (AMS) datings were introduced later.
Oberlin, Christine   +1 more
core   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

open access: yesAdvanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong   +14 more
wiley   +1 more source

Pasados releídos: el Dolmen del Portillo de las Cortes. Guadalajara / MAN [PDF]

open access: yesBoletín del Museo Arqueológico Nacional, 2016
La oportunidad de retomar el estudio del dolmen del Portillo de las Cortes, Guadalajara, a partir de los materiales conservados en el MAN y de recientes trabajos de campo, ofrece un resultado positivo.
P. Bueno Ramírez   +10 more
doaj  

Nanoparticle‐Mediated TIPE1 mRNA Delivery Enhances Paclitaxel Sensitivity in Triple‐Negative Breast Cancer by Modulating RAB7A Ubiquitination‐Associated Stability and Autophagy

open access: yesAdvanced Science, EarlyView.
TIPE1m NPs nanoparticles restore TIPE1 expression, promote RAB7A ubiquitination and degradation, suppress autophagic flux, and resensitize paclitaxel‐resistant triple‐negative breast cancer to therapy. ABSTRACT Acquired paclitaxel (PTX) resistance remains a major obstacle in triple‐negative breast cancer (TNBC) treatment.
Wei Hu   +9 more
wiley   +1 more source

La maqbara del Tossal de Manises (Alicante)

open access: yesLucentum, 2008
La última de las ocupaciones constatadas en el solar de la ciudad ibero-romana de Lucentum (Tossal de Manises), se documenta en el período islámico, donde el uso de parte de este espacio se ciñe exclusivamente al ámbito funerario.
Manuel Olcina Doménech   +2 more
doaj   +1 more source

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