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Synthesis of14C-labeled FAD-C44
Journal of Labelled Compounds and Radiopharmaceuticals, 2000Synthesis of 14 C -labeled FAD-C44 1 al the tertiary carbon by the dimerization of 14 C labeled erucic acid 2 is described. Labeling at the C-14 position of erucic acid is achieved hy a convergent approach involving the Wittig coupling of 14 C-labeled nonyl aldehyde 4 and the Wittig reagent 3.
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Journal of Labelled Compounds and Radiopharmaceuticals, 1999A concise synthetic methodology for selective deuterium labeling at the tertiary centers of the fatty acid dimer, FAD-C44 1 is described. Labeling methodology involves three steps and the deuterium is introduced at the tertiary carbons selectively by bromination of FAD-C44 followed by reduction with NaCNB2H3 and SnCl2.
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