Results 161 to 170 of about 16,995 (194)

Latcripin-7A from Lentinula edodes C91-3 induces apoptosis, autophagy, and cell cycle arrest at G1 phase in human gastric cancer cells via inhibiting PI3K/Akt/mTOR signaling

European Journal of Pharmacology, 2021
Gastric cancer (G.C) is one of the most lethal cancer types worldwide. Current treatment requires surgery along with chemotherapy, which causes obstacles for speedy recovery. The discovery of novel drugs is needed for better treatment of G.C with minimum side effects.
Syed Riaz Ud Din, Muhammad Azhar Nisar, Muhammad Noman Ramzan, Muhammad Zubair Saleem, Hassan Ghayas, Bashir Ahmad, Samana Batool, Kashif Kifayat, Xiaorong Guo, Min Huang, Mintao Zhong   +10 more
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Abstract C91: PyVmT luminal and EMT cell lines exhibit characteristic patterns of orthotopic and tail vein metastasis

Cancer Research, 2013
Abstract Understanding pathways leading to metastasis remains a primary goal of breast cancer research. Epithelial to mesenchymal transition (EMT) is thought to be critical in this process as tumor cells migrate through the stroma and undergo deformation while passing endothelial cells to enter the circulation. To examine the role of EMT
Lesley G. Ellies, Christopher Kuo
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Latcripin-7A, derivative of Lentinula edodes C91–3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells

Applied Microbiology and Biotechnology, 2020
Due to the high mortality rate and an increase in breast cancer incidence, it has been challenging for researchers to come across an effective chemotherapeutic strategy with minimum side effects. Therefore, the need for the development of effective chemotherapeutic drugs is still on the verge. Consequently, we approached a new mechanism to address this
Syed Riaz Ud Din, Mintao Zhong, Muhammad Azhar Nisar, Muhammad Zubair Saleem, Akbar Hussain, Kavish H. Khinsar, Shahid Alam, Gohar Ayub, Sadia Kanwal, Xingyun Li, Wei Zhang, Xiaoli Wang, Anhong Ning, Jing Cao, Min Huang   +14 more
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Expression and functional analysis of novel molecule — Latcripin-13 domain from Lentinula edodes C91-3 produced in prokaryotic expression system

Gene, 2015
The shiitake mushroom Lentinula edodes has health benefits and is used to treat various diseases due to its immunomodulatory and antineoplastic properties. In the present study, the Latcripin-13 domain, isolated from L. edodes, was expressed in Escherichia coli Rosetta-gami(DE3) in the form of inclusion bodies.
Jia, Wang, Mintao, Zhong, Ben, Liu, Li, Sha, Yongzhi, Lun, Wei, Zhang, Xingyun, Li, Xiaoli, Wang, Jing, Cao, Anhong, Ning, Min, Huang   +10 more
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From Inducing Autophagy to Programmed Cell Death? The PI3K Functional Domain Study of Protein Latcripin-1 from Lentinula edodes C91-3

International Journal of Peptide Research and Therapeutics, 2014
The functional study of the edible mycoprotein is important for elucidating the efficacy mechanism of fungi. There are more broad prospects on the field of antitumor mycoprotein. The expression map of Lentinula edodes C91-3 was sequenced and analyzed on the previous work. A novel antitumor mycoprotein—Latcripin-1 (LP1) was found at the first time.
Ben Liu, Siruo Zhang, Mintao Zhong, Li Sha, Yongzhi Lun, Wei Zhang, Xiaoli Wang, Xingyun Li, Jing Cao, Anhong Ning, Min Huang   +10 more
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Abstract C91: Pharmacodynamic analysis of the Hsp90 inhibitor STA-9090 in a lung cancer xenograft model supports an infrequent dosing schedule in the clinic

Molecular Cancer Therapeutics, 2009
Abstract Background: Heat shock protein 90 (Hsp90) is a molecular chaperone that is required for the stability and function of many important signal transduction proteins that regulate the growth of cancer cells. Hsp90 inhibition results in ubiquitination and proteasomal degradation of these client proteins, which include clinically ...
Kevin P. Foley, Takeshi Shimamura, Ron K. Blackman, Christa L. Borgman, Takayo Inoue, Tim Korbut, David Proia, Jim Sang, Luisa Shin Ogawa, Don Smith, Noriaki Tatsuta, Chaohua Zhang, Haili Zhang, Weiwen Ying, Geoffrey I. Shapiro, James Barsoum   +15 more
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Expression and Antitumor Function of Latcripin-4 RCC1 and ANK Domain Protein on HepG2 from the Shiitake Medicinal Mushroom, Lentinus edodes C91–3 (Agaricomycetes), Transcriptome

International Journal of Medicinal Mushrooms, 2018
The recombinant protein of Latcripin-4 regulator of chromosome condensation 1 (RCC1) and ankyrin (ANK) domains were expressed and the antitumor activity of Latcripin-4 on HepG2 cells was studied. First, the Latcripin-4 transcript was selected from the medicinal mushroom Lentinus edodes C91-3 transcriptome by bioinformatics. Then the full-length gene of
Xuefang, Guo, Xiaoli, Wang, Min, Liu, Lei, Chen, Warren, Chanda, Arshad Ahmed, Pahiar, Xingyun, Li, Wei, Zhang, Anhong, Ning, Min, Huang, Jing, Cao, Mintao, Zhong   +11 more
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Antiproliferative Protein from the Culture Supernatant of Lentinula Edodes C_91-3 Mycelia

Journal of Agricultural and Food Chemistry, 2014
We purified and isolated a novel protein (LFP(91-3)A2) with antitumor effect from Lentinula edodes C(91-3) liquid mycelial culture supernatant. LFP(91-3)A2 was purified by (NH4)2SO4 precipitation, ion-exchange chromatography (DEAE-cellulose) and gel filtration chromatography (Sephacryl S-200HR).
Xingyun, Li, Mintao, Zhong, Ben, Liu, Xiaoli, Wang, Lei, Liu, Wei, Zhang, Min, Huang   +6 more
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MPEC 2025-C91 : 2022 LX16

The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
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De novo characterization of Lentinula edodes C91-3 transcriptome by deep Solexa sequencing

Biochemical and Biophysical Research Communications, 2013
Lentinula edodes, has been utilized as food, as well as, in popular medicine, moreover, its extract isolated from its mycelium and fruiting body have shown several therapeutic properties. Yet little is understood about its genes involved in these properties, and the absence of L.edodes genomes has been a barrier to the development of functional ...
Mintao, Zhong, Ben, Liu, Xiaoli, Wang, Lei, Liu, Yongzhi, Lun, Xingyun, Li, Anhong, Ning, Jing, Cao, Min, Huang   +8 more
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