Results 241 to 250 of about 618,626 (288)

Integrating Physiology and Multi-Omics Reveals Mechanisms Underlying Sperm Activation and Movement in Mandarin Fish (<i>Siniperca chuatsi</i>). [PDF]

Animals (Basel)
Wang Q, Zhang Y, Huang Z, Zhang W, Wu Y, Li J, Zhang Y, Li L, Zhu Z, Meng Z.   +9 more
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Mechanistic Modeling of MCUx Gatekeeping, Ca²⁺ Transport, and Coupled Cytosolic-Mitochondrial Ca²⁺ Dynamics. [PDF]

Am J Physiol Cell Physiol
Asefa YD, Dave DD, Audi SH, Xie D, Bai X, Cowley AW, Dash RK.   +6 more
europepmc   +1 more source

Unraveling Hierarchical B‐Site Ordering: Mechanism of Microwave Dielectric Enhancement in Complex Perovskite Oxide Ceramics

Advanced Science, EarlyView.
This study maps out the hierarchical ordering in 1:2 B‐site complex perovskite ceramics using a comprehensive multiscale characterization route. It turns out that intradomain strain, oxygen vacancies, and Mg disorder within the ordered domains act as strong phonon scatterers.
Qingqiao Fu, Hui Gu, Hanbin Gao, Pianpian Ma, Xiangming Chen, Juanjuan Xing, Qiang Zheng   +6 more
wiley   +1 more source

Synaptic mitochondrial dysfunction and Alzheimer's disease: from molecular mechanisms to therapeutic strategies. [PDF]

Front Pharmacol
Wang Y, Wu W, Yan L, Zhang B, Li Q, Zhou Y.   +5 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Asymmetric distribution of mitochondrial Ca²⁺ regulators specifies compartment-specific mitochondrial function and neuronal development. [PDF]

Exp Mol Med
Jang DC, Kim SY, Kim WS, Choi IY, Jang E, Jung H, Chung C, Bang S, Kim HN, Choi HW, Han K, Cho Y, Kwon SK.   +12 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Mitochondrial Ca²⁺ Influx via MCU-1 Contributes to Oxidative Mitochondrial Defects in PDR-1/Parkin-Deficient <i>Caenorhabditis elegans</i> Body-Wall Muscle. [PDF]

Antioxidants (Basel)
Kawasumi M, Teranishi M.
europepmc   +1 more source