Results 221 to 230 of about 438,683 (248)
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Ca2+ Signaling and Intracellular Ca2+ Binding Proteins
Journal of Biochemistry, 1996Changes in cytosolic Ca2+ concentrations evoke a wide range of cellular responses and intracellular Ca(2+)-binding proteins are the key molecules to transduce Ca2+ signaling via enzymatic reactions or modulation of protein/protein interations (Fig.1).
I, Niki +4 more
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Inhibition of erythrocyte Ca2+-PUMP BY Ca2+ antagonists
Biochemical Pharmacology, 1990Inside-out vesicularized membrane fragments from human erythrocytes were prepared to study the effects of various Ca2+ channel entry blockers of plasma membrane Ca2+ transport and (Ca2+ + Mg2+)-ATPase activity concomitantly. Verapamil and diltiazem (0.01 to 5 mM) inhibited both (Ca2+ + Mg2+)-ATPase activity and initial rates of 45Ca2+ net uptake ...
B U, Raess, D M, Record
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L-type Ca2+ channels in Ca2+ channelopathies
Biochemical and Biophysical Research Communications, 2004Voltage-gated L-type Ca2+ channels (LTCCs) mediate depolarization-induced Ca2+ entry in electrically excitable cells, including muscle cells, neurons, and endocrine and sensory cells. In this review we summarize the role of LTCCs for human diseases caused by genetic Ca2+ channel defects (channelopathies).
Jörg, Striessnig +9 more
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Journal of Molecular and Cellular Cardiology, 1987
Ca research in the heart was historically surveyed. First, reference was made to the development of the concept involving Ca2+ in the contraction of skeletal muscle. This was followed by an overview of studies on Ca regulation in cardiac muscle. Emphasis was laid on the fact that the "Ca era" today originated from Ca research in muscle initiated by ...
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Ca research in the heart was historically surveyed. First, reference was made to the development of the concept involving Ca2+ in the contraction of skeletal muscle. This was followed by an overview of studies on Ca regulation in cardiac muscle. Emphasis was laid on the fact that the "Ca era" today originated from Ca research in muscle initiated by ...
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Ca2+ Pumps and Ca2+ Antiporters in Plant Development
2010Calcium (Ca2+) efflux transporters remove Ca2+ from the cytosol of the cell either by transporting it out of the cell across the plasma membrane or into internal organelles. These transporters, which include Ca2+-ATPases and Ca2+/H+ antiporters, have a critical role in preventing Ca2+ toxicity, maintaining cytosolic Ca2+ at a low resting level, and ...
J. K. Pittman +2 more
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Ca2+-stimulated ATPase: inactivation by Ca2+ and mechanism
Molecular and Cellular Biochemistry, 1982The preincubation of the rat blood cell membranes in the presence of low Ca2+ levels causes an irreversible inhibition of the Ca2+-stimulated ATPase activity. The inactivation is dependent on the Ca2+ concentration and the apparent Ki is identical to the Ca2+ concentration needed to reach the half-maximal activity of the enzyme.
C H, Pedemonte, H F, Balegno
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Ca2+ resting current and Ca2+-induced Ca2+ release in insect neurosecretory neurons
NeuroReport, 1998The effect of a Ca2+ resting current on spiking and intracellular Ca2+ concentration [Ca2+]i of isolated cockroach dorsal unpaired median neurons was investigated by combining microfluometry (Fura2) with patchclamping. The resting current was reduced by 10 microM 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) and 10 microM mefenamic acid, which ...
M, Heine, D, Wicher
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Regulation of Ca2+ fluxes in rat liver mitochondria by Ca2+. Effects on Ca2+ distribution
Journal of Bioenergetics and Biomembranes, 1990Rat liver mitochondria are able to temporarily lower the steady-state concentration of external Ca2+ after having accumulated a pulse of added Ca2+. This has been attributed to inhibition of a putative delta psi-modulated efflux pathway [Bernardi, P. (1984) Biochim. Biophys. Acta 766, 277-282].
N E, Saris, H, Kröner
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Mitochondrial VDAC, the Na+/Ca2+ Exchanger, and the Ca2+ Uniporter in Ca2+ Dynamics and Signaling
2017Mitochondrial Ca2+ uptake and release play pivotal roles in cellular physiology by regulating intracellular Ca2+ signaling, energy metabolism, and cell death. Ca2+ transport across the inner and outer mitochondrial membranes (IMM, OMM, respectively), is mediated by several proteins, including the voltage-dependent anion channel 1 (VDAC1) in the OMM ...
Varda, Shoshan-Barmatz, Soumasree, De
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Na+/Ca2+ Exchange and Cellular Ca2+ Homeostasis
Journal of Bioenergetics and Biomembranes, 1998The Na+/Ca2+ exchange system is the primary Ca2+ efflux mechanism in cardiac myocytes, and plays an important role in controlling the force of cardiac contraction. The exchanger protein contains 11 transmembrane segments plus a large hydrophilic domain between the 5th and 6th transmembrane segments; the transmembrane regions are responsible for ...
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