Results 121 to 130 of about 10,961,826 (306)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

CA 15-3, CRP, and LDH correlates with prognostic parameters in canine mammary neoplasms. [PDF]

Anim Reprod, 2023
Pinheiro BQ, de Magalhães FF, Alves FWDS, Silva ING, Faustino AMR, da Silva LDM.   +5 more
europepmc   +1 more source

Space-Time Distribution of G-Band and Ca II H-Line Intensity Oscillations in Hinode/SOT-FG Observations

, 2009
We study the space-time distributions of intensity fluctuations in 2 - 3 hour sequences of multi-spectral, high-resolution, high-cadence broad-band filtergram images (BFI) made by the SOT-FG system aboard the Hinode spacecraft. In the frequency range 5.5
A. C. Cadavid, A. Vecchio, A. Vecchio, A.C. Cadavid, A.M. Title, A.V. Getling, C. Torrence, F. Berrilli, F. Cattaneo, G.D. Nelson, J. K. Lawrence, J.K. Lawrence, J.K. Lawrence, J.K. Lawrence, K. Ichimoto, M. Rieutord, M.P. Rast, O. Steiner, P.G. Judge, P.N. Brandt, S. Tsuneta, S. UeNo, S.R.O. Ploner, T. Kosugi, T. Shimizu, T.D. Tarbell, T.E. Berger, U. Mitra-Kraev, Y. Suematsu, Å. Nordlund   +29 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Time Series measurements of White Blood Cells (WBC) and plasma Cancer Antigen 15-3 (CA 15-3) in a patient with metastatic breast cancer, serving as a reference for assessing the clinical relevance of different clustering algorithms.

Applied Medical Informatics
Clustering is highly valuable for analyzing cancer marker time series data. In a recent study, the significance of the K-means clustering algorithm was examined for the first time in evaluating time-series measurements of plasma Cancer Antigen 15-3 (CA ...
Alexandros CLOUVAS
doaj  

Interleukin 1 Alpha Gene Polymorphism in Breast Cancer After Chemotherapy Treatment

Medical Journal of Babylon
Background:The interleukin 1 (IL-1) family of cytokines is essential for triggering and controlling immunological and inflammatory responses. We believe the levels of these cytokines in breast tumor homogenates relate to other known prognosticators of ...
Frial Gemeel Abd, Sawsan Hassan Kadhum, Wurud Ali Hathal   +2 more
doaj   +1 more source

CA 15-3 in Human Breast Cancer.: Comparison with Tissue Polypeptide Antigen (TPA) and Carcinoembryonic Antigen (CEA)

The International Journal of Biological Markers, 1990
CEA, TPA, CA 15-3 were assayed in 238 patients in follow-up for breast cancer after surgery. CA 15-3 showed the best sensitivity and specificity; the predictive value of a positive CA 15-3 test was three times higher than CEA and TPA.
F. Caponigro, R.V. Iaffaioli, C. Pagliarulo, S. De Placido, G. Frasci, B. Ungaro, E. Matano, A.R. Bianco   +7 more
doaj   +1 more source

The Goss Farm Site (41FN12) on Bois d’Arc Creek, Fannin County, Texas [PDF]

, 2015
The Goss Farm site (41FN12) is an ancestral Caddo settlement on an alluvial landform on the west side of Bois d’Arc Creek near its confluence with the Red River.
Perttula, Timothy K.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source