Results 221 to 230 of about 1,191,145 (307)

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Prognostic value of body composition on early recurrence and long-term survival of resectable pancreatic ductal adenocarcinoma. [PDF]

Eur Radiol
Wu L, Nie T, Zhi X, Ouyang D, Zhang L, Wu H, Li X, Wu H, Han P, Chen L, Wu F, Zheng C.   +11 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Clinicopathological Characteristics and Survival Outcomes in Patients With Gastric Adenocarcinoma: A 16-Year Experience From a Single Tertiary Center in Tunisia. [PDF]

Cureus
Bouazzi A, Lagha S, Azri M, Beltaifa M, Farhat W, Harrabi F, Mizouni A, Missaoui N, Ben Mabrouk M.   +8 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Pilot study of screening method for pancreatic cancer using lipidomic profiling of plasma or serum. [PDF]

Commun Med (Lond)
Peterka O, Jirásko R, Dolečková Z, Dosoudilová M, Bártl J, Idkowiak J, Slavíček O, Pešková K, Vošmik M, Mohelníková-Duchoňová B, Kozubíková I, Loveček M, Urban O, Trna J, Karásek P, Melichar B, Holčapek M.   +16 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Futility of resection after neoadjuvant therapy in pancreatic ductal adenocarcinoma. [PDF]

iScience
Luo HT, Xie ZQ, Chen SJ, Yu QQ, Xu XY, Wu J, Teng TH.   +6 more
europepmc   +1 more source

Hypofractionated Radiotherapy Induces ISG15+MHC‐I+ Neutrophils to Augment Anti‐Tumor Immunity and Prime Immune Checkpoint Blockade Responses in Rectal Cancer

Advanced Science, EarlyView.
ABSTRACT Our previous clinical trials had demonstrated that neoadjuvant hypofractionated radiotherapy (HFRT) combined with immunotherapy yields promising clinical outcomes in locally advanced rectal cancer (LARC). However, this combined modality benefits only a subset of patients, highlighting the need to uncover the mechanisms underlying how ...
Lichao Liu, Haihong Wang, Mingjie Li, Qian Xu, Linlin Zheng, Chaoqun Han, Zhenwei Zou, Jinghua Ren, Xiaorong Dong, Peng Zhang, Kaixiong Tao, Zhenyu Lin, Tao Zhang   +12 more
wiley   +1 more source

Long-term and short-term outcomes of curative-intent resection for elderly and younger patients with gallbladder carcinoma: a multicentre propensity score-matched cohort study. [PDF]

eGastroenterology
Pan Y, Ye CY, Zhao P, Dai HS, Jiang Y, Huang YC, Chen C, Luo YL, Ding JJ, Ding R, Yue P, Huang F, Yu C, Wu ZP, Chen W, Zhou JX, Guo W, Yin DL, Chen W, Zhu Y, Bai J, Zhang YQ, Zhang D, Wang YY, Yang YL, Liu ZP, Guo R, Chen ZY, Biliary Surgery Branch of the Chinese Society of Digestive Surgery.   +28 more
europepmc   +1 more source