Harnessing benefit from targeting tumor associated carbohydrate antigens [PDF]
Human Vaccines & Immunotherapeutics, 2017 Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment.
Thomas Kieber-Emmons +4 more
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Conjugate Vaccines Targeting Tumor-Associated Carbohydrate Antigens [PDF]
VaccinesThe surface of cancer cells is covered in abnormal carbohydrate antigens that facilitate tumor growth, immune evasion and metastasis. Overexpressed and often specific to cancer cells, these tumor-associated carbohydrate antigens (TACAs) offer a valuable ...
Nadine Rosenglick +4 more
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A Multi-marker model based on serum IL-10 predicts response to conversion immunochemotherapy in gastric cancer patients: a retrospective cohort study [PDF]
BMC GastroenterologyBackground Conversion immunochemotherapy may enable curative surgery in patients with initially unresectable locally advanced gastric cancer, but its response rate remains low.
Xingzhou Wang +15 more
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Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment [PDF]
Frontiers in ImmunologyBackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao +7 more
doaj +2 more sources
Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses [PDF]
Innate ImmunityDendritic cells (DCs) orchestrate antitumor immunity by integrating signals from the tumor microenvironment to prime effective T cell responses. Many tumors display altered glycosylation patterns, including tumor-associated carbohydrate antigens (TACAs ...
Carolina Chiale +3 more
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Liposome‐Based Potential Vaccines Platforms that Are Noncytotoxic [PDF]
ChemistryOpenSynthetic vaccines represent a promising avenue in cancer immunotherapy by promoting targeted immune responses. Liposomal technologies have further advanced synthetic vaccinology by enabling the efficient delivery of tumor‐associated carbohydrate ...
Saida Mebarek +4 more
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Tumor-Associated Carbohydrate Antigens Targeting Immunotherapy
Trends in Glycoscience and Glycotechnology, 2021 Yasuyuki Matsumoto
exaly +2 more sources
Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response
Molecules, 2023 KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance ...
Yang Liu +4 more
doaj +1 more source
Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates
Frontiers in Immunology, 2022 For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design.
Joseph J. Barchi
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Tumor markers in pleural effusion caused by bronchogenic carcinoma and tuberculosis [PDF]
Vojnosanitetski Pregled, 2002 Concentrations of carcinoembryonic antigen (CEA) and carbon hydrate antigen (CA) 50 were measured in pleural effusion and sera of 57 patients with bronchogenic carcinoma and in 73 patients in whom the effusion was the sequelae of tuberculosis pleurisy ...
Plavec Goran +4 more
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