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Harnessing benefit from targeting tumor associated carbohydrate antigens [PDF]

Human Vaccines & Immunotherapeutics, 2017
Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment.
Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi, Laura F. Hutchins, Angela Pennisi, Issam Makhoul   +4 more
doaj   +5 more sources

A Multi-marker model based on serum IL-10 predicts response to conversion immunochemotherapy in gastric cancer patients: a retrospective cohort study [PDF]

BMC Gastroenterology
Background Conversion immunochemotherapy may enable curative surgery in patients with initially unresectable locally advanced gastric cancer, but its response rate remains low.
Xingzhou Wang, Hang Jiang, Mengjie Liang, Daming Cai, Shichao Ai, Qiongyuan Hu, Feng Wang, Feng Sun, Xuefeng Xia, Peng Song, Liang Tao, Song Liu, Meng Wang, Xiaofeng Lu, Wenxian Guan, Xiaofei Shen   +15 more
doaj   +2 more sources

Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment [PDF]

Frontiers in Immunology
BackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao, Cegang Fu, Boya Gong, Hongyan Wu, Ruitao Zhang, Huili Cai, Haidan Chen, Haidan Chen   +7 more
doaj   +2 more sources

Liposome‐Based Potential Vaccines Platforms that Are Noncytotoxic [PDF]

ChemistryOpen
Synthetic vaccines represent a promising avenue in cancer immunotherapy by promoting targeted immune responses. Liposomal technologies have further advanced synthetic vaccinology by enabling the efficient delivery of tumor‐associated carbohydrate ...
Saida Mebarek, Killian Jacob, Carmela Ilaria Pierro, Davide Romanini, Michele Fiore   +4 more
doaj   +2 more sources

Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response

Molecules, 2023
KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance ...
Yang Liu, Bohan Li, Xiujing Zheng, Decai Xiong, Xinshan Ye   +4 more
doaj   +1 more source

Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates

Frontiers in Immunology, 2022
For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design.
Joseph J. Barchi
doaj   +1 more source

Tumor markers in pleural effusion caused by bronchogenic carcinoma and tuberculosis [PDF]

Vojnosanitetski Pregled, 2002
Concentrations of carcinoembryonic antigen (CEA) and carbon hydrate antigen (CA) 50 were measured in pleural effusion and sera of 57 patients with bronchogenic carcinoma and in 73 patients in whom the effusion was the sequelae of tuberculosis pleurisy ...
Plavec Goran, Ninković Momčilo, Kozlovački Gordana, Lazarov Angel, Tatić Vujadin   +4 more
doaj   +1 more source

Human T cell glycosylation and implications on immune therapy for cancer [PDF]

, 2020
Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome.
Callewaert, Nico, De Bousser, Elien, Festjens, Nele, Meuris, Leander   +3 more
core   +1 more source

A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

Journal of Translational Medicine, 2022
Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and represent ...
Francesca Rosato, Rajeev Pasupuleti, Jana Tomisch, Ana Valeria Meléndez, Dajana Kolanovic, Olga N. Makshakova, Birgit Wiltschi, Winfried Römer   +7 more
doaj   +1 more source

Recognition of Dimeric Lewis X by Anti-Dimeric Le^x Antibody SH2

Vaccines, 2020
The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.
Sinthuja Jegatheeswaran, Ari Asnani, Adam Forman, Jenifer L. Hendel, Christopher J. Moore, Ali Nejatie, An Wang, Jo-Wen Wang, France-Isabelle Auzanneau   +8 more
doaj   +1 more source