Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. [PDF]
Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL).
Graham P. Collins +34 more
core +2 more sources
Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Manzenrieder, Florian +20 more
core +1 more source
Developments in Carbohydrate-Based Cancer Therapeutics
Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been ...
Farzana Hossain, Peter R. Andreana
doaj +1 more source
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +12 more
core +1 more source
Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]
Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core +1 more source
Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines
Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
Richard James Payne +2 more
doaj +1 more source
Vaccinia virus expressing ICP47 : a novel platform for cancer vaccines highlighting tumor epitopes and hiding viral antigens [PDF]
Background Recombinant poxviruses expressing tumor associated antigens (TAAs) are evaluated since 20 years as immunogenic vaccine vector in clinical trials.
Raafat, Nermin Abdel Fattah
core +1 more source
A variety of glycan structures cover the surface of all cells and are involved in myriad biological processes, including but not limited to, cell adhesion and communication, protein quality control, signal transduction and metabolism, while also being ...
Joseph J. Barchi, Caitlin N. Strain
doaj +1 more source
Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. [PDF]
BACKGROUND: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.
Vidyagouri Shinde +46 more
core +2 more sources
Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses
Carbohydrates are regarded as promising targets for vaccine development against infectious disease because cell surface glycans on many infectious agents are attributed to playing an important role in pathogenesis.
Sharmeen Nishat, Peter R. Andreana
doaj +1 more source

