Results 1 to 10 of about 80,597 (162)

Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions [PDF]

BMC Cancer, 2022
Background The Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior studies have relied heavily upon poorly characterized in-house generated antibodies and lectins. In this
Gabrielle E. Dombek, Ana Sofia Ore, Jane Cheng, Yasuyuki Matsumoto, Jonathan N. Glickman, Aaron Fleishman, Jamie Heimburg-Molinaro, Vitaliy Y. Poylin, Anne Fabrizio, Thomas Cataldo, Evangelos Messaris, Richard D. Cummings   +11 more
doaj   +2 more sources

The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers [PDF]

Frontiers in Oncology, 2023
Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer progression, these mechanisms are manipulated to become harmful. O-glycosylation, a crucial post-translational modification, is one such pathway that can lead to
Christabelle Rajesh, Prakash Radhakrishnan   +1 more
doaj   +2 more sources

Challenges in Antibody Development against Tn and Sialyl-Tn Antigens [PDF]

Biomolecules, 2015
The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive ...
Liliana R. Loureiro, Mylène A. Carrascal, Ana Barbas, José S. Ramalho, Carlos Novo, Philippe Delannoy, Paula A. Videira   +6 more
doaj   +5 more sources

Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer [PDF]

Frontiers in Oncology, 2020
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking.
Lenneke A. M. Cornelissen, Athanasios Blanas, Anouk Zaal, Joost C. van der Horst, Laura J. W. Kruijssen, Tom O’Toole, Yvette van Kooyk, Sandra J. van Vliet   +7 more
doaj   +2 more sources

Overexpression of Tn antigen induces chronic pancreatitis in mice [PDF]

Scientific Reports
Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N ...
Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Elena Neuburg, Jan Kempski, Christoph Wagener, Nathaniel Melling, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld   +9 more
doaj   +2 more sources

The Cosmc connection to the Tn antigen in cancer. [PDF]

Cancer Biomark, 2014
The Tn antigen is a tumor-associated carbohydrate antigen that is not normally expressed in peripheral tissues or blood cells. Expression of this antigen, which is found in a majority of human carcinomas of all types, arises from a blockage in the normal O-glycosylation pathway in which glycans are extended from the common precursor GalNAcα1-O-Ser/Thr (
Ju T, Aryal RP, Kudelka MR, Wang Y, Cummings RD.   +4 more
europepmc   +4 more sources

The Tn antigen-structural simplicity and biological complexity. [PDF]

Angew Chem Int Ed Engl, 2011
AbstractGlycoproteins in animal cells contain a variety of glycan structures that are added co‐ and/or posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages known, the two major types are N‐glycans (Asn‐linked) and O‐glycans (Ser/Thr‐linked).
Ju T, Otto VI, Cummings RD.
europepmc   +5 more sources

Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice

Frontiers in Immunology, 2021
Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization.
Taeko K. Noah, Taeko K. Noah, Jee-Boong Lee, Christopher A. Brown, Amnah Yamani, Amnah Yamani, Sunil Tomar, Sunil Tomar, Varsha Ganesan, Varsha Ganesan, Rodney D. Newberry, Gary B. Huffnagle, Gary B. Huffnagle, Senad Divanovic, Senad Divanovic, Senad Divanovic, Simon P. Hogan, Simon P. Hogan   +17 more
doaj   +1 more source

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Biomedicines, 2022
Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also
Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel   +11 more
doaj   +1 more source

Primary breast cancer tumours contain high amounts of IgA1 immunoglobulin: an immunohistochemical analysis of a possible carrier of the tumour-associated Tn antigen. [PDF]

PLoS ONE, 2013
The Tn antigen (GalNAc alpha-O-Ser/Thr) as defined by the binding of the lectin, helix pomatia agglutinin (HPA) or anti-Tn monoclonal antibodies, is known to be exposed in a majority of cancers, and it has also been shown to correlate positively with the
Charlotte Welinder, Bo Baldetorp, Ola Blixt, Dorthe Grabau, Bo Jansson   +4 more
doaj   +1 more source