Tn Antigen Expression Contributes to an Immune Suppressive Microenvironment and Drives Tumor Growth in Colorectal Cancer [PDF]
Frontiers in Oncology, 2020 Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking.
Lenneke A. M. Cornelissen +7 more
doaj +3 more sources
Immunohistochemical analysis of Tn antigen expression in colorectal adenocarcinoma and precursor lesions [PDF]
BMC Cancer, 2022 Background The Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior studies have relied heavily upon poorly characterized in-house generated antibodies and lectins. In this
Gabrielle E. Dombek +11 more
doaj +2 more sources
The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers [PDF]
Frontiers in Oncology, 2023 Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer progression, these mechanisms are manipulated to become harmful. O-glycosylation, a crucial post-translational modification, is one such pathway that can lead to
Christabelle Rajesh +1 more
doaj +2 more sources
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens [PDF]
Biomolecules, 2015 The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive ...
Liliana R. Loureiro +6 more
doaj +5 more sources
Overexpression of Tn antigen induces chronic pancreatitis in mice [PDF]
Scientific ReportsAltered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N ...
Baris Mercanoglu +9 more
doaj +2 more sources
Rational design of a Tn antigen mimic [PDF]
Chemical Communications, 2011 3 páginas, 3 figuras, 1 tabla -- PAGS nros. 5319-5321A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural
Jesús Jiménez-Barbero +21 more
core +4 more sources
Effect of anticancer therapy on Tn antigen exposure on the leucocyte membranes in patients with leukemia [PDF]
Regulatory Mechanisms in Biosystems, 2014 Tn-antigen (Thomsen-nouvelle antigen) is tumor-associated carbohydrate antigen with only one GalNAc residue attached to serine or threonine of polypeptide chain.
G. S. Maslak
doaj +2 more sources
Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia
Transfusion, 1992 Expression of the normally cryptic blood group antigen Tn has occasionally been reported in hematologic disease, but the true frequency of this change is not known.
MB Pfeiffer (15885215) +3 more
core +3 more sources
Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer. [PDF]
Int J Mol Sci, 2020 Colorectal cancer (CRC) cells often express Tn antigen, a tumor-associated truncated immature O-glycan (GalNAcα-O-Ser/Thr) that can promote tumor progression.
Matsumoto T +18 more
europepmc +2 more sources
Detection of Tn, sialyn-Tn and T antigens in HNPCC
, 1996 The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway.
G. BARRESI +4 more
core +2 more sources