Results 21 to 30 of about 81,953 (280)
, 2021 Alterations in glycosylation cause the emergence of tumor-associated carbohydrate antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen nouveau (Tn) antigen, an N-acetylgalactosamine (GalNAc) frequently attached to serine or ...
Maxime Henry (4376956) +21 more
core +1 more source
Stem Cell Research & Therapy, 2023 Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu +6 more
doaj +1 more source
Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]
, 2018 N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724) +35 more
core +1 more source
Expression of tumor-associated antigens in breast cancer subtypes
Breast, 2020 Objectives: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer.
Giuseppe Curigliano +9 more
doaj +1 more source
Frontiers in Immunology, 2023 Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active ...
Wout de Mey +10 more
doaj +1 more source
Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome [PDF]
Japanese journal of human genetics, 1992 In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. The cells were analyzed with flow cytometry employing an anti-Tn antibody and a lectin of Vicia villosa which recognizes only the Tn determinant.
Y, Kamitani +3 more
openaire +2 more sources
Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen
, 2021 The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most ...
John F., Trant +4 more
core +1 more source
Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease
Biomolecules, 2022 The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang +4 more
doaj +1 more source
Cancer Management and Research, 2022 Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj
Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG
Scientific Reports, 2023 The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival.
Yasuyuki Matsumoto +3 more
doaj +1 more source