Results 31 to 40 of about 81,953 (280)

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

Acta Pharmaceutica Sinica B, 2022
We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule.
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao   +8 more
doaj   +1 more source

Shigella flexneri targets human colonic goblet cells by O antigen binding to Sialyl-Tn and Tn antigens via glycan-glycan interactions

, 2020
Shigella flexneri targets colonic cells in humans to initiate invasive infection processes that lead to dysentery, and direct interactions between their lipopolysaccharide O antigens and blood group A related glycans are involved in the cell adherence ...
Tran, ENH, Poole, J., Tran, E.N.H., Tse, E., Jennings, M.P., Morona, R, Poole, J, Tse, E, Day, C.J., McCartney, E., Day, CJ, Jennings, MP, McCartney, E, Morona, R.   +13 more
core   +1 more source

Sialyl-tn antigen expression in Crohn's colitis [PDF]

Inflammatory Bowel Diseases, 1997
: Expression of the mucin-associated sialyl-Tn (STn) antigen is correlated with malignant progression in the colon. In patients with longstanding ulcerative colitis (UC) who never exhibited colonic dysplasia, STn was expressed in fewer than 15% of nondysplastic surveillance colonoscopic biopsies, whereas matched patients who developed colon cancer ...
A, Ta, N, Harpaz, C, Bodian, A, Roston, L, Oberman, A, Chen, S, Itzkowitz   +6 more
openaire   +2 more sources

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

Frontiers in Chemistry, 2022
The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared via solid-phase ...
Jonathan P. Dolan, Darren C. Machin, Simone Dedola, Robert A. Field, Robert A. Field, Michael E. Webb, W. Bruce Turnbull   +6 more
doaj   +1 more source

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

Journal for ImmunoTherapy of Cancer, 2023
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine the ...
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother   +15 more
doaj   +1 more source

The GalNAc-T Activation Pathway (GALA) is not a general mechanism for regulating mucin-type O-glycosylation.

PLoS ONE, 2017
Mucin-type O-glycosylation is initiated by the UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Their activity results in the GalNAc α1-O-Thr/Ser structure, termed the Tn antigen, which is further decorated with ...
Gaetan G Herbomel, Raul E Rojas, Duy T Tran, Monica Ajinkya, Lauren Beck, Lawrence A Tabak   +5 more
doaj   +1 more source

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

BMC Cancer, 2018
Background The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or ...
Xiaodong Sun, Tongzhong Ju, Richard D. Cummings   +2 more
doaj   +1 more source

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens

Cancer Management and Research, 2020
Feng Xu,1,* Dong Wang,2,* JianXiu Cui,1 Jie Li,1 Hongchuan Jiang1 1Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Department of Oncology, Affiliated Hospital of ...
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines

Frontiers in Molecular Biosciences, 2022
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation.
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Roman Krawetz, Niclas G. Karlsson, Niclas G. Karlsson   +15 more
doaj   +1 more source

Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions

Materials Today Bio, 2022
Drug delivery using nanoparticles (NPs) represents a potential approach for therapy in cancer, such gastric cancer (GC) due to their targeting ability and controlled release properties.
Francisca Diniz, Maria Azevedo, Flávia Sousa, Hugo Osório, Diana Campos, Paula Sampaio, Joana Gomes, Bruno Sarmento, Celso A. Reis   +8 more
doaj   +1 more source