Harnessing benefit from targeting tumor associated carbohydrate antigens [PDF]
Human Vaccines & Immunotherapeutics, 2017 Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment.
Thomas Kieber-Emmons +4 more
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Conjugate Vaccines Targeting Tumor-Associated Carbohydrate Antigens [PDF]
VaccinesThe surface of cancer cells is covered in abnormal carbohydrate antigens that facilitate tumor growth, immune evasion and metastasis. Overexpressed and often specific to cancer cells, these tumor-associated carbohydrate antigens (TACAs) offer a valuable ...
Nadine Rosenglick +4 more
doaj +3 more sources
Cancer vaccine with mimotopes of tumor-associated carbohydrate antigens. [PDF]
Immunol Res, 2010 The GD2 ganglioside, displayed by five carbohydrate Neu5Acalpha2-8Neu5Acalpha2-3(GalNAcbeta1-4)Galbeta1-4Glcbeta residues attached to a ceramide chain that anchors the ganglioside in the cell membrane, is expressed on neuroectodermally derived tumors. GD2 has been used as a target for passive and active immunotherapy in patients with malignant melanoma
Kozbor D.
europepmc +4 more sources
Tobacco mosaic virus as a new carrier for tumor associated carbohydrate antigens. [PDF]
Bioconjug Chem, 2012 Tumor-associated carbohydrate antigens (TACAs) are being actively studied as targets for antitumor vaccine development. One serious challenge was the low immunogenecity of these antigens. Herein, we report the results of using the tobacco mosaic virus (TMV) capsid as a promising carrier of a weakly immunogenic TACA, the monomeric Tn antigen. The copper(
Yin Z +8 more
europepmc +5 more sources
A Multi-marker model based on serum IL-10 predicts response to conversion immunochemotherapy in gastric cancer patients: a retrospective cohort study [PDF]
BMC GastroenterologyBackground Conversion immunochemotherapy may enable curative surgery in patients with initially unresectable locally advanced gastric cancer, but its response rate remains low.
Xingzhou Wang +15 more
doaj +2 more sources
Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment [PDF]
Frontiers in ImmunologyBackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao +7 more
doaj +2 more sources
Synthesis of Biotinylated Tumor-Associated Carbohydrate Antigens for Immunological Studies. [PDF]
Tetrahedron Lett, 2009 Syntheses of several biotinylated human cancer-associated carbohydrate antigens for immunological studies are described.
Zhu J, Wan Q, Danishefsky SJ.
europepmc +4 more sources
Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses [PDF]
Innate ImmunityDendritic cells (DCs) orchestrate antitumor immunity by integrating signals from the tumor microenvironment to prime effective T cell responses. Many tumors display altered glycosylation patterns, including tumor-associated carbohydrate antigens (TACAs ...
Carolina Chiale +3 more
doaj +2 more sources
Liposome‐Based Potential Vaccines Platforms that Are Noncytotoxic [PDF]
ChemistryOpenSynthetic vaccines represent a promising avenue in cancer immunotherapy by promoting targeted immune responses. Liposomal technologies have further advanced synthetic vaccinology by enabling the efficient delivery of tumor‐associated carbohydrate ...
Saida Mebarek +4 more
doaj +2 more sources
Tumor-Associated Carbohydrate Antigens Targeting Immunotherapy
Trends in Glycoscience and Glycotechnology, 2021 Yasuyuki Matsumoto
exaly +2 more sources