Results 21 to 30 of about 9,201,633 (292)

Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines

Frontiers in Chemistry, 2015
Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
Richard James Payne, David M McDonald, Scott N Byrne   +2 more
doaj   +1 more source

Vaccinia virus expressing ICP47 : a novel platform for cancer vaccines highlighting tumor epitopes and hiding viral antigens [PDF]

, 2010
Background Recombinant poxviruses expressing tumor associated antigens (TAAs) are evaluated since 20 years as immunogenic vaccine vector in clinical trials.
Raafat, Nermin Abdel Fattah
core   +1 more source

The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation

Frontiers in Molecular Biosciences, 2023
A variety of glycan structures cover the surface of all cells and are involved in myriad biological processes, including but not limited to, cell adhesion and communication, protein quality control, signal transduction and metabolism, while also being ...
Joseph J. Barchi, Caitlin N. Strain
doaj   +1 more source

Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. [PDF]

, 2011
BACKGROUND: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.
Vidyagouri Shinde, Lavanya Suneetha, Karuna Devi, Wim H. van Brakel, Shinde, V., Suneetha Lavanya, Diana N J Lockwood, Jadhav, Rupendra, Nicholls Peter G., Peter G Nicholls, Chaduvula Meher Vani, Suneetha, L., Kamble Ravindra, Devi, K., Raju, Renuka, Jadhav Rupendra, Devi Karuna, Peter G. Nicholls, Diana N. J. Lockwood, Kamble, Ravindra, Lockwood, Diana NJ, Jadhav, R., Chaduvula, M.V., Suneetha, Sujai, Lockwood, D.N.J., Suneetha Sujai, Suneetha, Lavanya, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Raju, R., Suneetha, S., Devi, Karuna, Sujai Suneetha, Nicholls, Peter G, Kamble, R., Lockwood Diana N. J., Rupendra Jadhav, Nicholls, P.G., Shinde, Vidyagouri, Chaduvula, Meher Vani, Shinde Vidyagouri, van Brakel, W.H., Raju Renuka, Renuka Raju, Ravindra Kamble, Meher Vani Chaduvula   +46 more
core   +2 more sources

Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses

Vaccines, 2016
Carbohydrates are regarded as promising targets for vaccine development against infectious disease because cell surface glycans on many infectious agents are attributed to playing an important role in pathogenesis.
Sharmeen Nishat, Peter R. Andreana
doaj   +1 more source

Carbohydrate Mimetic Peptides for Pan Anti-Tumor Responses

Frontiers in Immunology, 2014
Molecular mimicry is fundamental to biology which transcends to many disciplines ranging from immune pathology to drug design. Structural characterization of molecular partners has provided insight into the origins and relative importance of ...
Thomas eKieber-Emmons, Anastas ePashov, Somdutta eSaha, Behjatolah eMonzavi-Karbassi, Ramachandran eMurali   +4 more
doaj   +1 more source

Tumor associated antigens in diagnosis of serous effusions [PDF]

, 1988
The use of tumour associated antigens in the diagnosis of serous effusions was studied in 76 patients with benign and 200 patients with malignant disease.
Permanetter, W., Mezger, J., Lamerz, Rolf, Wilmanns, W., Gerbes, Alexander L.   +4 more
core   +1 more source

Increasing the Antigenicity of Synthetic Tumor‐Associated Carbohydrate Antigens by Targeting Toll‐Like Receptors [PDF]

ChemBioChem, 2009
AbstractSynthetic cancer vaccines: A number of fully synthetic vaccine candidates have been designed, chemically synthesized, and immunologically evaluated to establish a strategy to overcome the poor immunogenicity of tumor‐associated carbohydrates and glycopeptides and to determine the importance of Toll‐like receptor (TLR) engagement for antigenic ...
Sampat, Ingale, Margreet A, Wolfert, Therese, Buskas, Geert-Jan, Boons   +3 more
openaire   +2 more sources

Altered Glycosylation in Progression and Management of Bladder Cancer

Molecules, 2023
Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of ...
Magdalena Wilczak, Magdalena Surman, Małgorzata Przybyło   +2 more
doaj   +1 more source

Trypsin digest of cancer cells surface stimulates anti-tumor immune response better than cancer cells themselves [PDF]

, 2010
Antigens expressed on the surface of cancer cells are accessible targets for both humoral and cell-mediated immune responses, and are therefore potential candidates for vaccine development.
Balashova Elena, Petr Lokhov
core   +1 more source