Results 21 to 30 of about 24,022 (284)

Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]

, 2006
Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core   +1 more source

Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. [PDF]

, 2011
BACKGROUND: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.
Vidyagouri Shinde, Lavanya Suneetha, Karuna Devi, Wim H. van Brakel, Shinde, V., Suneetha Lavanya, Diana N J Lockwood, Jadhav, Rupendra, Nicholls Peter G., Peter G Nicholls, Chaduvula Meher Vani, Suneetha, L., Kamble Ravindra, Devi, K., Raju, Renuka, Jadhav Rupendra, Devi Karuna, Peter G. Nicholls, Diana N. J. Lockwood, Kamble, Ravindra, Lockwood, Diana NJ, Jadhav, R., Chaduvula, M.V., Suneetha, Sujai, Lockwood, D.N.J., Suneetha Sujai, Suneetha, Lavanya, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Raju, R., Suneetha, S., Devi, Karuna, Sujai Suneetha, Nicholls, Peter G, Kamble, R., Lockwood Diana N. J., Rupendra Jadhav, Nicholls, P.G., Shinde, Vidyagouri, Chaduvula, Meher Vani, Shinde Vidyagouri, van Brakel, W.H., Raju Renuka, Renuka Raju, Ravindra Kamble, Meher Vani Chaduvula   +46 more
core   +1 more source

Lectin ligands: New insights into their conformations and their dynamic behavior and the discovery of conformer selection by lectins [PDF]

, 1998
The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides, In the interplay with lectins sugar-code words of ...
Kozár, T., Frank, M., Gabius, H.-J., Kaltner, Herbert, Bovin, Nicolai V., Lieth, C.-W. von der, Burchert, M., Tajkhorshid, Emadeddin, Gilleron, M., Siebert, H.-C., Tajkhorshid, E., Kayser, Gian, Siebert, H. C., Vliegenthart, JFG, Vliegenthart, J.F.G., Bovin, N.V., Vliegenthart, Johannes F. G., Gabius, Hans-Joachim, Bovin, N. V., Burchert, Maria, Kaltner, H., Gilleron, Martine, von Der Lieth, C.-W., Kayser, G., Tajkhorshid, Emad, Lieth, Claus-Wilhelm von der, Leith, C.-W. von der   +26 more
core   +1 more source

Synthetic Self-Adjuvanting Glycopeptide Cancer Vaccines

Frontiers in Chemistry, 2015
Due to changes in glycosyltransferase expression during tumorigenesis, the glycoproteins of cancer cells often carry highly truncated carbohydrate chains compared to those on healthy cells.
Richard James Payne, David M McDonald, Scott N Byrne   +2 more
doaj   +1 more source

The effect of a methyl group on structure and function: Serine vs. threonine glycosylation and phosphorylation

Frontiers in Molecular Biosciences, 2023
A variety of glycan structures cover the surface of all cells and are involved in myriad biological processes, including but not limited to, cell adhesion and communication, protein quality control, signal transduction and metabolism, while also being ...
Joseph J. Barchi, Caitlin N. Strain
doaj   +1 more source

Increasing the Antigenicity of Synthetic Tumor‐Associated Carbohydrate Antigens by Targeting Toll‐Like Receptors [PDF]

ChemBioChem, 2009
AbstractSynthetic cancer vaccines: A number of fully synthetic vaccine candidates have been designed, chemically synthesized, and immunologically evaluated to establish a strategy to overcome the poor immunogenicity of tumor‐associated carbohydrates and glycopeptides and to determine the importance of Toll‐like receptor (TLR) engagement for antigenic ...
Sampat, Ingale, Margreet A, Wolfert, Therese, Buskas, Geert-Jan, Boons   +3 more
openaire   +2 more sources

Entirely Carbohydrate-Based Vaccines: An Emerging Field for Specific and Selective Immune Responses

Vaccines, 2016
Carbohydrates are regarded as promising targets for vaccine development against infectious disease because cell surface glycans on many infectious agents are attributed to playing an important role in pathogenesis.
Sharmeen Nishat, Peter R. Andreana
doaj   +1 more source

Altered Glycosylation in Progression and Management of Bladder Cancer

Molecules, 2023
Bladder cancer (BC) is the 10th most common malignancy worldwide, with an estimated 573,000 new cases and 213,000 deaths in 2020. Available therapeutic approaches are still unable to reduce the incidence of BC metastasis and the high mortality rates of ...
Magdalena Wilczak, Magdalena Surman, Małgorzata Przybyło   +2 more
doaj   +1 more source

A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes. [PDF]

PLoS ONE, 2017
Single-agent immunotherapy is ineffective against poorly immunogenic cancers, including pancreatic ductal adenocarcinoma (PDAC). The aims of this study were to demonstrate the feasibility of production of novel autologous tumor lysate vaccines from ...
Kenta Furukawa, Masahiro Tanemura, Eiji Miyoshi, Hidetoshi Eguchi, Hiroaki Nagano, Katsuyoshi Matsunami, Satoshi Nagaoka, Daisaku Yamada, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Goto, Kiyomi Taniyama, Masaki Mori, Yuichiro Doki   +15 more
doaj   +1 more source

Carbohydrate antigen 15-3 as a marker of disease severity in patients with chronic hypersensitivity pneumonitis* [PDF]

Jornal Brasileiro de Pneumologia
Objective: Biomarkers associated with mucin 1, such as Krebs von den Lungen-6 and carbohydrate antigen (CA) 15-3, are increased in various interstitial lung diseases.
Paula Silva Gomes, Maria Raquel Soares, Maria Fernanda Munhoz Lages Marchenta, Gustavo de Souza Portes Meirelles, Rimarcs Gomes Ferreira, André Bezerra Botelho, Rafaela Boaventura Martins, Carlos Alberto de Castro Pereira   +7 more
doaj   +4 more sources