Cancer vaccine with mimotopes of tumor-associated carbohydrate antigens. [PDF]
Immunol Res, 2010 The GD2 ganglioside, displayed by five carbohydrate Neu5Acalpha2-8Neu5Acalpha2-3(GalNAcbeta1-4)Galbeta1-4Glcbeta residues attached to a ceramide chain that anchors the ganglioside in the cell membrane, is expressed on neuroectodermally derived tumors. GD2 has been used as a target for passive and active immunotherapy in patients with malignant melanoma
Kozbor D.
europepmc +4 more sources
Tobacco mosaic virus as a new carrier for tumor associated carbohydrate antigens. [PDF]
Bioconjug Chem, 2012 Tumor-associated carbohydrate antigens (TACAs) are being actively studied as targets for antitumor vaccine development. One serious challenge was the low immunogenecity of these antigens. Herein, we report the results of using the tobacco mosaic virus (TMV) capsid as a promising carrier of a weakly immunogenic TACA, the monomeric Tn antigen. The copper(
Yin Z +8 more
europepmc +5 more sources
Tumour-associated carbohydrate antigens in breast cancer
, 2010 Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival.
Sylvain Julien +9 more
core +6 more sources
Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. [PDF]
, 2011 Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL).
Graham P. Collins +34 more
core +2 more sources
Establishment of a Human Monoclonal Antibody to Hanganutziu‐Deicher Antigen as a Tumor‐associated Carbohydrate Antigen [PDF]
Japanese Journal of Cancer Research, 1988 We have established a human‐human hybridoma producing a monoclonal antibody against a tumor‐associated carbohydrate‐specific antigen, Hanganutziu‐Deicher (HD) antigen. Human spleen lymphocytes from a patient with esophageal varices complicated with liver cirrhosis were cultured in serum‐free medium and co‐stimulated with both anti‐human μ‐chain ...
Usuba, Osamu +4 more
openaire +3 more sources
Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]
, 2009 Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Manzenrieder, Florian +20 more
core +1 more source
Developments in Carbohydrate-Based Cancer Therapeutics
Pharmaceuticals, 2019 Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been ...
Farzana Hossain, Peter R. Andreana
doaj +1 more source
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +12 more
core +1 more source
Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]
, 2006 Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core +1 more source
Synthesis of biotinylated tumor-associated carbohydrate antigens for immunological studies [PDF]
Tetrahedron Letters, 2009 Syntheses of several biotinylated human cancer-associated carbohydrate antigens for immunological studies are described.
Jianglong, Zhu +2 more
openaire +2 more sources