Carbohydrate Mimetic Peptides for Pan Anti-Tumor Responses
Frontiers in Immunology, 2014 Molecular mimicry is fundamental to biology which transcends to many disciplines ranging from immune pathology to drug design. Structural characterization of molecular partners has provided insight into the origins and relative importance of ...
Thomas eKieber-Emmons +4 more
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Developments in Carbohydrate-Based Cancer Therapeutics
Pharmaceuticals, 2019 Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been ...
Farzana Hossain, Peter R. Andreana
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Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens [PDF]
CellRaymond W Zhou, Michael A Demetriou
exaly +2 more sources
Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response
Molecules, 2023 KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance ...
Yang Liu +4 more
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Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates
Frontiers in Immunology, 2022 For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design.
Joseph J. Barchi
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Tumor markers in pleural effusion caused by bronchogenic carcinoma and tuberculosis [PDF]
Vojnosanitetski Pregled, 2002 Concentrations of carcinoembryonic antigen (CEA) and carbon hydrate antigen (CA) 50 were measured in pleural effusion and sera of 57 patients with bronchogenic carcinoma and in 73 patients in whom the effusion was the sequelae of tuberculosis pleurisy ...
Plavec Goran +4 more
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A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death
Journal of Translational Medicine, 2022 Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and represent ...
Francesca Rosato +7 more
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Recognition of Dimeric Lewis X by Anti-Dimeric Lex Antibody SH2
Vaccines, 2020 The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.
Sinthuja Jegatheeswaran +8 more
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Establishment of a Human Monoclonal Antibody to Hanganutziu‐Deicher Antigen as a Tumor‐associated Carbohydrate Antigen [PDF]
Japanese Journal of Cancer Research, 1988 We have established a human‐human hybridoma producing a monoclonal antibody against a tumor‐associated carbohydrate‐specific antigen, Hanganutziu‐Deicher (HD) antigen. Human spleen lymphocytes from a patient with esophageal varices complicated with liver cirrhosis were cultured in serum‐free medium and co‐stimulated with both anti‐human μ‐chain ...
Usuba, Osamu +4 more
openaire +3 more sources
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +12 more
core +1 more source