Results 41 to 50 of about 44,629 (299)
Chemoenzymatic Syntheses of Tumor‐Associated Carbohydrate Antigen Globo‐H and Stage‐Specific Embryonic Antigen 4 [PDF]
Advanced Synthesis & Catalysis, 2008 AbstractGangliosides have attracted much attention due to their important biological properties. Herein we report the first chemoenzymatic syntheses of two globo series of ganglioside oligosaccharides, Globo‐H 1 and stage‐specific embryonic antigen‐4 (SSEA‐4) 2.
Zhen, Wang +9 more
openaire +2 more sources
Tumor-Associated Glycans and Immune Surveillance
Vaccines, 2013 Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that
Anastas Pashov +2 more
doaj +1 more source
Biomedicines, 2023 Background: Suppressor of fused (SuFu) is a tumor-suppressor gene that regulates hedgehog signaling. Its involvement in some malignancies is broadly accepted. However, its association with colorectal cancer (CRC) pathogenesis is not clear.
Tahseen Bilal Rather +11 more
doaj +1 more source
Targeted therapy of advanced gallbladder cancer and cholangiocarcinoma with aggressive biology: eliciting early response signals from phase 1 trials. [PDF]
, 2013 PurposePatients with advanced cholangiocarcinoma (CC) and gallbladder carcinoma (GC) have few therapeutic options for relapsed disease. methods: Given the overall poor prognosis in this population and the availability of novel targeted therapies, we ...
Falchook, Gerald S +14 more
core +2 more sources
State of the Art in CAR-T Cell Therapy for Solid Tumors: Is There a Sweeter Future?
CellsChimeric antigen receptor (CAR)-T cell therapy has proven to be a powerful treatment for hematological malignancies. The situation is very different in the case of solid tumors, for which no CAR-T-based therapy has yet been approved.
Beatriz Amorós-Pérez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Cancer biomarkers, and novel techniques for detection [PDF]
, 2017 Technologies for early detection of tumors is critical for better therapy outcome and overall change in cancer survival. These assays must be capable of detecting tumors at early stages in order to prevent metastasis of the tumor and help reduce ...
Jamal, Tameem
core
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source
MGL Receptor and Immunity: When the Ligand Can Make the Difference
Journal of Immunology Research, 2015 C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer.
Ilaria Grazia Zizzari +7 more
doaj +1 more source
Appearance of Inflammation in Peripheral Blood during Menstrual Cycles in Women of Childbearing Age
Reproductive and Developmental Medicine, 2018 Background: Chronic inflammation has been reported as a triggering and driving factor in the pathogenesis of various diseases and is believed to be closely associated with tumor pathogenesis.
Hai-Lun Liu +5 more
doaj +1 more source