Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition and adhesion [PDF]
, 2004 Carbohydrates at the cell surface have been proposed as mediators in cell-cell recognition events involved in embryogenesis, metastasis, and other proliferation processes by calcium-dependent carbohydrate to carbohydrate interactions.
Bucior, Iwona
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Tumor-Associated Glycans and Immune Surveillance
Vaccines, 2013 Changes in cell surface glycosylation are a hallmark of the transition from normal to inflamed and neoplastic tissue. Tumor-associated carbohydrate antigens (TACAs) challenge our understanding of immune tolerance, while functioning as immune targets that
Anastas Pashov +2 more
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State of the Art in CAR-T Cell Therapy for Solid Tumors: Is There a Sweeter Future?
CellsChimeric antigen receptor (CAR)-T cell therapy has proven to be a powerful treatment for hematological malignancies. The situation is very different in the case of solid tumors, for which no CAR-T-based therapy has yet been approved.
Beatriz Amorós-Pérez +4 more
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Biomedicines, 2023 Background: Suppressor of fused (SuFu) is a tumor-suppressor gene that regulates hedgehog signaling. Its involvement in some malignancies is broadly accepted. However, its association with colorectal cancer (CRC) pathogenesis is not clear.
Tahseen Bilal Rather +11 more
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MGL Receptor and Immunity: When the Ligand Can Make the Difference
Journal of Immunology Research, 2015 C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer.
Ilaria Grazia Zizzari +7 more
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Abstract 2993: Unmutated tumor antigens are abundant and contribute to tumor control in melanoma
, 2023 peer reviewedAbstract Recognition of MHC-I-associated tumor antigens (TAs) by CD8+ T cells is central to antitumor immunity. Owing to the elevated tumor mutational burden (TMB) in melanoma, the marked efficacy of immune checkpoint ...
Zhao, Qingchuan +13 more
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BMC GastroenterologyBackground Conversion immunochemotherapy may enable curative surgery in patients with initially unresectable locally advanced gastric cancer, but its response rate remains low.
Xingzhou Wang +15 more
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Appearance of Inflammation in Peripheral Blood during Menstrual Cycles in Women of Childbearing Age
Reproductive and Developmental Medicine, 2018 Background: Chronic inflammation has been reported as a triggering and driving factor in the pathogenesis of various diseases and is believed to be closely associated with tumor pathogenesis.
Hai-Lun Liu +5 more
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Exposure to Abnormal Self Antigens During Non-Malignant Inflammatory Events Provides Immunological Defense Against Tumors [PDF]
, 2013 Cancer immunosurveillance is the body’s sentinel mechanism of recognizing and eliminating malignancy. Specifically, the immune system can mount a response against cancer through the recognition of tumor associated antigens (TAA). While studying two TAAs,
Iheagwara, Uzoma
core
Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy. [PDF]
, 2007 Epstein-Barr virus (EBV) is associated with a number of human malignancies. EBV-positive post-transplant lymphoproliferative disease in solid organ and hematopoietic stem cell transplant recipients has been successfully treated by the adoptive transfer ...
Burdach, S. +36 more
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