Results 51 to 60 of about 1,162 (187)

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment

Frontiers in Immunology
BackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao, Cegang Fu, Boya Gong, Hongyan Wu, Ruitao Zhang, Huili Cai, Haidan Chen, Haidan Chen   +7 more
doaj   +1 more source

Human dendritic cell activation induced by a permannosylated dendron containing an antigenic GM3-lactone mimetic

Beilstein Journal of Organic Chemistry, 2014
Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response.
Renato Ribeiro-Viana, Elena Bonechi, Javier Rojo, Clara Ballerini, Giuseppina Comito, Barbara Richichi, Cristina Nativi   +6 more
doaj   +1 more source

Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers

Frontiers in Oncology, 2018
Application of the CAR targeting strategy in solid tumors is challenged by the need for adequate target antigens. As a consequence of their tissue origin, embryonal cancers can aberrantly express membrane-anchored gangliosides.
Claudia Rossig, Claudia Rossig, Sareetha Kailayangiri, Silke Jamitzky, Bianca Altvater   +4 more
doaj   +1 more source

Marcadores tumorais em pacientes com artrite reumatóide [PDF]

, 2010
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Bergamaschi, Samuel Brighenti
core  

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Trial watch: Peptide-based vaccines in anticancer therapy

OncoImmunology, 2018
Peptide-based anticancer vaccination aims at stimulating an immune response against one or multiple tumor-associated antigens (TAAs) following immunization with purified, recombinant or synthetically engineered epitopes.
Lucillia Bezu, Oliver Kepp, Giulia Cerrato, Jonathan Pol, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi   +8 more
doaj   +1 more source

Evidence for Two Populated Conformations for the Dimeric LeX and LeALeX Tumor-Associated Carbohydrate Antigens

, 2014
The conformational behavior of tumor associated carbohydrate antigens (TACAs) dimLex and LeaLex was studied using a combination of NMR experiments and molecular dynamic simulations.
Jackson, Trudy A., Auzanneau, France-Isabelle, Valerie Robertson, France-Isabelle Auzanneau, Trudy A. Jackson, Robertson, Valerie   +5 more
core   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, EarlyView.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

Tumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response

Abnormal glycosylation is a hallmark of tumor development, and tumor-associated carbohydrate antigens are potential immune targets for tumor therapy. Tumor-associated extracellular microvesicles are subcellular vesicles released from cell membranes that ...
Gefei Li (4687666), You Zou (2601964), Xin-Shan Ye (1393843), Juan Mo (8638113), Yang Liu (4829), Bo-Han Li (3965351), Xiu-Jing Zheng (2221669)   +6 more
core   +1 more source