Results 51 to 60 of about 9,201,478 (158)
A novel autoantibody signatures for enhanced clinical diagnosis of pancreatic ductal adenocarcinoma
Cancer Cell International, 2023 Background Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease that requires precise diagnosis for effective treatment. However, the diagnostic value of carbohydrate antigen 19 − 9 (CA19-9) is limited.
Tiandong Li +9 more
doaj +1 more source
Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment
Frontiers in ImmunologyBackgroundAbnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohydrate antigens ...
Shuailong Zhao +7 more
doaj +1 more source
Challenges in Antibody Development against Tn and Sialyl-Tn Antigens
Biomolecules, 2015 The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive ...
Liliana R. Loureiro +6 more
doaj +1 more source
Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]
, 2010 Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M. +2 more
core
Beilstein Journal of Organic Chemistry, 2014 Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response.
Renato Ribeiro-Viana +6 more
doaj +1 more source
Carbohydrate Targets for CAR T Cells in Solid Childhood Cancers
Frontiers in Oncology, 2018 Application of the CAR targeting strategy in solid tumors is challenged by the need for adequate target antigens. As a consequence of their tissue origin, embryonal cancers can aberrantly express membrane-anchored gangliosides.
Claudia Rossig +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 The α-gal epitope is a carbohydrate antigen which appeared early in mammalian evolution and is synthesized in large amounts by the glycosylation enzyme α1,3galactosyltransferase (α1,3GT) in non-primate mammals, lemurs, and New-World monkeys.
Uri Galili
doaj +1 more source
Trial watch: Peptide-based vaccines in anticancer therapy
OncoImmunology, 2018 Peptide-based anticancer vaccination aims at stimulating an immune response against one or multiple tumor-associated antigens (TAAs) following immunization with purified, recombinant or synthetically engineered epitopes.
Lucillia Bezu +8 more
doaj +1 more source
Abnormal glycosylation is a hallmark of tumor development, and tumor-associated carbohydrate antigens are potential immune targets for tumor therapy. Tumor-associated extracellular microvesicles are subcellular vesicles released from cell membranes that ...
Gefei Li (4687666) +6 more
core +1 more source
Effect of immunization with fetal cells on adenovirus-12 oncogenesis [PDF]
, 1974 The effect of immunization with hamster fetal cells on the tumor induction by adnovirus type 12 was studied by in vivo and in vitro. The immunization with lO-day old fetal cells showed a recognizable inhibition on the tumor induction by adenovirus type ...
Abe, Shinji
core +1 more source