Results 11 to 20 of about 1,162 (187)

Harnessing benefit from targeting tumor associated carbohydrate antigens

Human Vaccines & Immunotherapeutics, 2017
Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment.
Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi, Laura F. Hutchins, Angela Pennisi, Issam Makhoul   +4 more
doaj   +2 more sources

Developments in Carbohydrate-Based Cancer Therapeutics

Pharmaceuticals, 2019
Cancer cells of diverse origins express extracellular tumor-specific carbohydrate antigens (TACAs) because of aberrant glycosylation. Overexpressed TACAs on the surface of tumor cells are considered biomarkers for cancer detection and have always been ...
Farzana Hossain, Peter R. Andreana
doaj   +2 more sources

Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response

Molecules, 2023
KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance ...
Yang Liu, Bohan Li, Xiujing Zheng, Decai Xiong, Xinshan Ye   +4 more
doaj   +1 more source

Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates

Frontiers in Immunology, 2022
For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design.
Joseph J. Barchi
doaj   +1 more source

Tumor markers in pleural effusion caused by bronchogenic carcinoma and tuberculosis [PDF]

Vojnosanitetski Pregled, 2002
Concentrations of carcinoembryonic antigen (CEA) and carbon hydrate antigen (CA) 50 were measured in pleural effusion and sera of 57 patients with bronchogenic carcinoma and in 73 patients in whom the effusion was the sequelae of tuberculosis pleurisy ...
Plavec Goran, Ninković Momčilo, Kozlovački Gordana, Lazarov Angel, Tatić Vujadin   +4 more
doaj   +1 more source

A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death

Journal of Translational Medicine, 2022
Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and represent ...
Francesca Rosato, Rajeev Pasupuleti, Jana Tomisch, Ana Valeria Meléndez, Dajana Kolanovic, Olga N. Makshakova, Birgit Wiltschi, Winfried Römer   +7 more
doaj   +1 more source

Recognition of Dimeric Lewis X by Anti-Dimeric Le^x Antibody SH2

Vaccines, 2020
The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.
Sinthuja Jegatheeswaran, Ari Asnani, Adam Forman, Jenifer L. Hendel, Christopher J. Moore, Ali Nejatie, An Wang, Jo-Wen Wang, France-Isabelle Auzanneau   +8 more
doaj   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L   +12 more
core   +1 more source

Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]

, 2006
Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core   +1 more source

Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. [PDF]

, 2011
BACKGROUND: The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.
Vidyagouri Shinde, Lavanya Suneetha, Karuna Devi, Wim H. van Brakel, Shinde, V., Suneetha Lavanya, Diana N J Lockwood, Jadhav, Rupendra, Nicholls Peter G., Peter G Nicholls, Chaduvula Meher Vani, Suneetha, L., Kamble Ravindra, Devi, K., Raju, Renuka, Jadhav Rupendra, Devi Karuna, Peter G. Nicholls, Diana N. J. Lockwood, Kamble, Ravindra, Lockwood, Diana NJ, Jadhav, R., Chaduvula, M.V., Suneetha, Sujai, Lockwood, D.N.J., Suneetha Sujai, Suneetha, Lavanya, van Brakel, Wim H, van Brakel Wim H., Wim H van Brakel, Raju, R., Suneetha, S., Devi, Karuna, Sujai Suneetha, Nicholls, Peter G, Kamble, R., Lockwood Diana N. J., Rupendra Jadhav, Nicholls, P.G., Shinde, Vidyagouri, Chaduvula, Meher Vani, Shinde Vidyagouri, van Brakel, W.H., Raju Renuka, Renuka Raju, Ravindra Kamble, Meher Vani Chaduvula   +46 more
core   +1 more source