Harnessing benefit from targeting tumor associated carbohydrate antigens
Human Vaccines & Immunotherapeutics, 2017 Integrating additive or synergistic antitumor effects that focus on distinct elements of tumor biology are the most rational strategies for cancer treatment.
Thomas Kieber-Emmons +4 more
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Conjugate Vaccines Targeting Tumor-Associated Carbohydrate Antigens [PDF]
VaccinesThe surface of cancer cells is covered in abnormal carbohydrate antigens that facilitate tumor growth, immune evasion and metastasis. Overexpressed and often specific to cancer cells, these tumor-associated carbohydrate antigens (TACAs) offer a valuable ...
Nadine Rosenglick +4 more
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A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity [PDF]
Advanced ScienceTumor‐associated carbohydrate antigens (TACAs), such as the Tn antigen, are promising targets for cancer vaccines but are limited by their low immunogenicity and a lack of T‐cell responses.
Wenbo Ming +9 more
doaj +2 more sources
Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses [PDF]
Innate ImmunityDendritic cells (DCs) orchestrate antitumor immunity by integrating signals from the tumor microenvironment to prime effective T cell responses. Many tumors display altered glycosylation patterns, including tumor-associated carbohydrate antigens (TACAs ...
Carolina Chiale +3 more
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Cancer Vaccines Based on Fluorine-Modified KH-1 Elicit Robust Immune Response
Molecules, 2023 KH-1 is a tumor-associated carbohydrate antigen (TACA), which serves as a valuable target of antitumor vaccines for cancer immunotherapies. However, most TACAs are thymus-independent antigens (TD-Ag), and they tend to induce immunological tolerance ...
Yang Liu +4 more
doaj +1 more source
Glycoconjugate Nanoparticle-Based Systems in Cancer Immunotherapy: Novel Designs and Recent Updates
Frontiers in Immunology, 2022 For many years, cell-surface glycans (in particular, Tumor-Associated Carbohydrate Antigens, TACAs) have been the target of both passive and active anticancer immunotherapeutic design.
Joseph J. Barchi
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Tumour-associated carbohydrate antigens in breast cancer
, 2010 Glycosylation changes that occur in cancer often lead to the expression of tumour-associated carbohydrate antigens. In breast cancer, these antigens are usually associated with a poor prognosis and a reduced overall survival.
Sylvain Julien +9 more
core +6 more sources
Tumor markers in pleural effusion caused by bronchogenic carcinoma and tuberculosis [PDF]
Vojnosanitetski Pregled, 2002 Concentrations of carcinoembryonic antigen (CEA) and carbon hydrate antigen (CA) 50 were measured in pleural effusion and sera of 57 patients with bronchogenic carcinoma and in 73 patients in whom the effusion was the sequelae of tuberculosis pleurisy ...
Plavec Goran +4 more
doaj +1 more source
A bispecific, crosslinking lectibody activates cytotoxic T cells and induces cancer cell death
Journal of Translational Medicine, 2022 Background Aberrant glycosylation patterns play a crucial role in the development of cancer cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate antigens attached to proteins and lipids on cell surfaces and represent ...
Francesca Rosato +7 more
doaj +1 more source
Recognition of Dimeric Lewis X by Anti-Dimeric Lex Antibody SH2
Vaccines, 2020 The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.
Sinthuja Jegatheeswaran +8 more
doaj +1 more source